-
1
-
-
0036851876
-
Platelets in atherothrombosis
-
Ruggeri ZM. Platelets in atherothrombosis. Nat Med. 2002;8(11):1227-1234.
-
(2002)
Nat Med
, vol.8
, Issue.11
, pp. 1227-1234
-
-
Ruggeri, Z.M.1
-
2
-
-
67649683031
-
The current state of antiplatelet therapy in acute coronary syndromes: The data and the real world
-
Alexander JH. The current state of antiplatelet therapy in acute coronary syndromes: the data and the real world. Cleve Clin J Med. 2009;76(suppl 1):S16-23.
-
(2009)
Cleve Clin J Med
, vol.76
, Issue.SUPPL. 1
-
-
Alexander, J.H.1
-
3
-
-
75949128633
-
Antiplatelet therapies for the treatment of cardiovascular disease
-
Michelson AD. Antiplatelet therapies for the treatment of cardiovascular disease. Nat Rev Drug Discov. 2010;9(2):154-169.
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.2
, pp. 154-169
-
-
Michelson, A.D.1
-
4
-
-
54049152026
-
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: A technology-driven saga of a receptor with twists, turns, and even a bend
-
Coller BS, Shattil SJ. The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood. 2008;112(8):3011-3025.
-
(2008)
Blood
, vol.112
, Issue.8
, pp. 3011-3025
-
-
Coller, B.S.1
Shattil, S.J.2
-
5
-
-
0037145037
-
Integrins: Bidirectional, allosteric signaling machines
-
Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110(6):673-687.
-
(2002)
Cell
, vol.110
, Issue.6
, pp. 673-687
-
-
Hynes, R.O.1
-
6
-
-
0032590042
-
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
-
Hodivala-Dilke KM, McHugh KP, Tsakiris DA, et al. Beta3-integrin- deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest. 1999;103(2):229-238.
-
(1999)
J Clin Invest
, vol.103
, Issue.2
, pp. 229-238
-
-
Hodivala-Dilke, K.M.1
McHugh, K.P.2
Tsakiris, D.A.3
-
7
-
-
0033838314
-
Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
-
Ni H, Denis CV, Subbarao S, et al. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest. 2000;106(3):385-392. (Pubitemid 30655638)
-
(2000)
Journal of Clinical Investigation
, vol.106
, Issue.3
, pp. 385-392
-
-
Ni, H.1
Denis, C.V.2
Subbarao, S.3
Degen, J.L.4
Sato, T.N.5
Hynes, R.O.6
Wagner, D.D.7
-
8
-
-
27444447117
-
The platelet P2 receptors as molecular targets for old and new antiplatelet drugs
-
DOI 10.1016/j.pharmthera.2005.03.009, PII S0163725805000835
-
Gachet C. The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Ther. 2005;108(2):180-192. (Pubitemid 41528788)
-
(2005)
Pharmacology and Therapeutics
, vol.108
, Issue.2
, pp. 180-192
-
-
Gachet, C.1
-
9
-
-
85047694005
-
12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries
-
DOI 10.1172/JCI200317864
-
Andre P. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest. 2003;112(3):398-406. (Pubitemid 38063768)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.3
, pp. 398-406
-
-
Andre, P.1
Delaney, S.M.2
LaRocca, T.3
Vincent, D.4
DeGuzman, F.5
Jurek, M.6
Koller, B.7
Phillips, D.R.8
Conley, P.B.9
-
10
-
-
77956319038
-
Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques
-
Nergiz-Unal R, Cosemans JM, Feijge MA, et al. Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques. PLoS ONE. 2010;5(4):e10130.
-
(2010)
PLoS ONE
, vol.5
, Issue.4
-
-
Nergiz-Unal, R.1
Cosemans, J.M.2
Feijge, M.A.3
-
11
-
-
52649163308
-
CalDAGGEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets
-
Cifuni SM, Wagner DD, Bergmeier W. CalDAGGEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets. Blood. 2008;112(5):1696-1703.
-
(2008)
Blood
, vol.112
, Issue.5
, pp. 1696-1703
-
-
Cifuni, S.M.1
Wagner, D.D.2
Bergmeier, W.3
-
12
-
-
70350511423
-
CalDAGGEFI is at the nexus of calcium-dependent platelet activation
-
Stefanini L, Roden RC, Bergmeier W. CalDAGGEFI is at the nexus of calcium-dependent platelet activation. Blood. 2009;114(12):2506-2514.
-
(2009)
Blood
, vol.114
, Issue.12
, pp. 2506-2514
-
-
Stefanini, L.1
Roden, R.C.2
Bergmeier, W.3
-
13
-
-
13144282666
-
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
-
DOI 10.1073/pnas.95.22.13278
-
Kawasaki H, Springett GM, Toki S, et al. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A. 1998;95(22):13278-13283. (Pubitemid 28509562)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.22
, pp. 13278-13283
-
-
Kawasaki, H.1
Springett, G.M.2
Toki, S.3
Canales, J.J.4
Harlan, P.5
Blumenstiel, J.P.6
Chen, E.J.7
Bany, I.A.8
Mochizuki, N.9
Ashbacher, A.10
Matsuda, M.11
Housman, D.E.12
Graybiel, A.M.13
-
14
-
-
4644221351
-
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
-
DOI 10.1038/nm1098
-
Crittenden JR, Bergmeier W, Zhang Y, et al. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med. 2004;10(9):982-986. (Pubitemid 39273740)
-
(2004)
Nature Medicine
, vol.10
, Issue.9
, pp. 982-986
-
-
Crittenden, J.R.1
Bergmeier, W.2
Zhang, Y.3
Piffath, C.L.4
Liang, Y.5
Wagner, D.D.6
Housman, D.E.7
Graybiel, A.M.8
-
15
-
-
67849116915
-
Novel molecules in calcium signaling in platelets
-
Bergmeier W, Stefanini L. Novel molecules in calcium signaling in platelets. J Thromb Haemost. 2009;7(suppl 1):187-190.
-
(2009)
J Thromb Haemost
, vol.7
, Issue.SUPPL. 1
, pp. 187-190
-
-
Bergmeier, W.1
Stefanini, L.2
-
16
-
-
34548167778
-
Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs
-
DOI 10.1042/BJ20070294
-
Johnson JE, Goulding RE, Ding Z, et al. Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs. Biochem J. 2007;406(2):223-236. (Pubitemid 47310953)
-
(2007)
Biochemical Journal
, vol.406
, Issue.2
, pp. 223-236
-
-
Johnson, J.E.1
Goulding, R.E.2
Ding, Z.3
Partovi, A.4
Anthony, K.V.5
Beaulieu, N.6
Tazmini, G.7
Cornell, R.B.8
Kay, R.J.9
-
17
-
-
61749097572
-
PK-Calpha regulates platelet granule secretion and thrombus formation in mice
-
Konopatskaya O, Gilio K, Harper MT, et al. PK-Calpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest. 2009; 119(2):399-407.
-
(2009)
J Clin Invest
, vol.119
, Issue.2
, pp. 399-407
-
-
Konopatskaya, O.1
Gilio, K.2
Harper, M.T.3
-
18
-
-
65349092897
-
Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis
-
Lian L, Wang Y, Flick M, et al. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood. 2009;113(15):3577-3584.
-
(2009)
Blood
, vol.113
, Issue.15
, pp. 3577-3584
-
-
Lian, L.1
Wang, Y.2
Flick, M.3
-
19
-
-
0036905073
-
Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonistinduced fibrinogen receptor activation
-
Quinton TM, Kim S, Dangelmaier C, et al. Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonistinduced fibrinogen receptor activation. Biochem J. 2002;368(Pt 2):535-543.
-
(2002)
Biochem J
, vol.368
, Issue.PART 2
, pp. 535-543
-
-
Quinton, T.M.1
Kim, S.2
Dangelmaier, C.3
-
20
-
-
0037023134
-
A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets
-
Lova P. A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets. J Biol Chem. 2002;277(14):12009-12015.
-
(2002)
J Biol Chem
, vol.277
, Issue.14
, pp. 12009-12015
-
-
Lova, P.1
-
22
-
-
34147140579
-
Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets
-
Zou Z, Chen H, Schmaier AA, Hynes RO, Kahn ML. Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets. Blood. 2007;109(8):3284-3290.
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3284-3290
-
-
Zou, Z.1
Chen, H.2
Schmaier, A.A.3
Hynes, R.O.4
Kahn, M.L.5
-
23
-
-
0036591801
-
Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody
-
DOI 10.1002/cyto.10114
-
Bergmeier W, Schulte V, Brockhoff G, Bier U, Zirngibl H, Nieswandt B. Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry. 2002;48(2):80-86. (Pubitemid 34591919)
-
(2002)
Cytometry
, vol.48
, Issue.2
, pp. 80-86
-
-
Bergmeier, W.1
Schulte, V.2
Brockhoff, G.3
Bier, U.4
Zirngibl, H.5
Nieswandt, B.6
-
24
-
-
56749092145
-
Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates
-
Neeves KB, Maloney SF, Fong KP, et al. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thromb Haemost. 2008;6(12):2193-2201.
-
(2008)
J Thromb Haemost
, vol.6
, Issue.12
, pp. 2193-2201
-
-
Neeves, K.B.1
Maloney, S.F.2
Fong, K.P.3
-
25
-
-
0034141860
-
Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies
-
Bergmeier W, Rackebrandt K, Schröder W, Zirngibl H, Nieswandt B. Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies. Blood. 2000;95(3):886-893.
-
(2000)
Blood
, vol.95
, Issue.3
, pp. 886-893
-
-
Bergmeier, W.1
Rackebrandt, K.2
Schröder, W.3
Zirngibl, H.4
Nieswandt, B.5
-
26
-
-
51649110213
-
Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots
-
Neyman M, Gewirtz J, Poncz M. Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots. Blood. 2008;112(4):1101-1108.
-
(2008)
Blood
, vol.112
, Issue.4
, pp. 1101-1108
-
-
Neyman, M.1
Gewirtz, J.2
Poncz, M.3
-
27
-
-
73049103413
-
Arterial thrombosis: Relevance of a model with two levels of severity assessed by histological, ultrastructural and functional characterization
-
Hechler B, Nonne C, Eckly A, et al. Arterial thrombosis: relevance of a model with two levels of severity assessed by histological, ultrastructural and functional characterization. J Thromb Haemost.2010;8(1):173-84.
-
(2010)
J Thromb Haemost
, vol.8
, Issue.1
, pp. 173-184
-
-
Hechler, B.1
Nonne, C.2
Eckly, A.3
-
28
-
-
34147139988
-
Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model
-
Dubois C, Panicot-Dubois L, Gainor JF, Furie BC, Furie B. Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest. 2007;117(4):953-960.
-
(2007)
J Clin Invest
, vol.117
, Issue.4
, pp. 953-960
-
-
Dubois, C.1
Panicot-Dubois, L.2
Gainor, J.F.3
Furie, B.C.4
Furie, B.5
-
29
-
-
34247190302
-
Platelet adhesion receptors and their ligands in mouse models of thrombosis
-
Denis CV, Wagner DD. Platelet adhesion receptors and their ligands in mouse models of thrombosis. Arterioscler Thromb Vasc Biol. 2007;27(4):728-739.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, Issue.4
, pp. 728-739
-
-
Denis, C.V.1
Wagner, D.D.2
-
30
-
-
34249863368
-
Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III
-
DOI 10.1172/JCI30575
-
Bergmeier W, Goerge T, Wang H-W, et al. Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest. 2007;117(6):1699-1707. (Pubitemid 46871354)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.6
, pp. 1699-1707
-
-
Bergmeier, W.1
Goerge, T.2
Wang, H.-W.3
Crittenden, J.R.4
Baldwin, A.C.W.5
Cifuni, S.M.6
Housman, D.E.7
Graybiel, A.M.8
Wagner, D.D.9
-
31
-
-
76549094772
-
Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases
-
Siller-Matula JM, Krumphuber J, Jilma B. Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases. Br J Pharmacol. 2010;159(3):502-517.
-
(2010)
Br J Pharmacol
, vol.159
, Issue.3
, pp. 502-517
-
-
Siller-Matula, J.M.1
Krumphuber, J.2
Jilma, B.3
-
32
-
-
0030800626
-
Anti-thrombotic effects and bleeding risk of AJvW-2, a monoclonal antibody against human von Willebrand factor
-
Kageyama S, Yamamoto H, Nagano M, Arisaka H, Kayahara T, Yoshimoto R. Anti-thrombotic effects and bleeding risk of AJvW-2, a monoclonal antibody against human von Willebrand factor. Br J Pharmacol. 1997;122(1):165-171.
-
(1997)
Br J Pharmacol
, vol.122
, Issue.1
, pp. 165-171
-
-
Kageyama, S.1
Yamamoto, H.2
Nagano, M.3
Arisaka, H.4
Kayahara, T.5
Yoshimoto, R.6
-
33
-
-
54949095069
-
The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons
-
Fontayne A, Meiring M, Lamprecht S, et al. The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons. Thromb Haemost. 2008;100(4):670-677.
-
(2008)
Thromb Haemost
, vol.100
, Issue.4
, pp. 670-677
-
-
Fontayne, A.1
Meiring, M.2
Lamprecht, S.3
-
34
-
-
37349040378
-
First-in-human evaluation of anti-von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers
-
DOI 10.1161/CIRCULATIONAHA.107.724864
-
Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, et al. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation. 2007;116(23):2678-2686. (Pubitemid 350291240)
-
(2007)
Circulation
, vol.116
, Issue.23
, pp. 2678-2686
-
-
Gilbert, J.C.1
DeFeo-Fraulini, T.2
Hutabarat, R.M.3
Horvath, C.J.4
Merlino, P.G.5
Marsh, H.N.6
Healy, J.M.7
BouFakhreddine, S.8
Holohan, T.V.9
Schaub, R.G.10
-
35
-
-
22044443427
-
The relative role of PLCbeta and PI3Kgamma in platelet activation
-
Lian L, Wang Y, Draznin J, et al. The relative role of PLCbeta and PI3Kgamma in platelet activation. Blood. 2005;106(1):110-117.
-
(2005)
Blood
, vol.106
, Issue.1
, pp. 110-117
-
-
Lian, L.1
Wang, Y.2
Draznin, J.3
-
37
-
-
37549029679
-
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo
-
Nieswandt B, Moser M, Pleines I, et al. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med. 2007;204(13):3113-3118.
-
(2007)
J Exp Med
, vol.204
, Issue.13
, pp. 3113-3118
-
-
Nieswandt, B.1
Moser, M.2
Pleines, I.3
-
38
-
-
37549064277
-
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
-
Petrich BG, Marchese P, Ruggeri ZM, et al. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med. 2007;204(13):3103-3111.
-
(2007)
J Exp Med
, vol.204
, Issue.13
, pp. 3103-3111
-
-
Petrich, B.G.1
Marchese, P.2
Ruggeri, Z.M.3
-
39
-
-
40449133970
-
Kindlin-3 is essential for integrin activation and platelet aggregation
-
DOI 10.1038/nm1722, PII NM1722
-
Moser M, Nieswandt B, Ussar S, Pozgajova M, Fässler R. Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med. 2008;14(3):325-330. (Pubitemid 351347914)
-
(2008)
Nature Medicine
, vol.14
, Issue.3
, pp. 325-330
-
-
Moser, M.1
Nieswandt, B.2
Ussar, S.3
Pozgajova, M.4
Fassler, R.5
-
40
-
-
62449156198
-
Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy
-
Crittenden JR, Cantuti-Castelvetri I, Saka E, et al. Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy. Proc Natl Acad Sci U S A. 2009;106(8):2892-2896.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.8
, pp. 2892-2896
-
-
Crittenden, J.R.1
Cantuti-Castelvetri, I.2
Saka, E.3
-
41
-
-
0034644772
-
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor
-
Clyde-Smith J, Silins G, Gartside M, et al. Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. J Biol Chem. 2000;275(41):32260-32267.
-
(2000)
J Biol Chem
, vol.275
, Issue.41
, pp. 32260-32267
-
-
Clyde-Smith, J.1
Silins, G.2
Gartside, M.3
-
42
-
-
0042858184
-
Exchange factors of the RasGRP family mediate Ras activation in the Golgi
-
Caloca MJ, Zugaza JL, Bustelo XR. Exchange factors of the RasGRP family mediate Ras activation in the Golgi. J Biol Chem. 2003;278(35):33465-33473.
-
(2003)
J Biol Chem
, vol.278
, Issue.35
, pp. 33465-33473
-
-
Caloca, M.J.1
Zugaza, J.L.2
Bustelo, X.R.3
-
44
-
-
0033515627
-
Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins
-
Hausser A, Storz P, Link G, et al. Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. J Biol Chem. 1999;274(14):9258-9264.
-
(1999)
J Biol Chem
, vol.274
, Issue.14
, pp. 9258-9264
-
-
Hausser, A.1
Storz, P.2
Link, G.3
-
45
-
-
0034698068
-
Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine- rich domain interactions
-
Williams JG, Drugan JK, Yi GS, Clark GJ, Der CJ, Campbell SL. Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine- rich domain interactions. J Biol Chem. 2000;275(29):22172-22179.
-
(2000)
J Biol Chem
, vol.275
, Issue.29
, pp. 22172-22179
-
-
Williams, J.G.1
Drugan, J.K.2
Yi, G.S.3
Clark, G.J.4
Der, C.J.5
Campbell, S.L.6
|