C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 8, 2012, Pages 1366-1377

  Gutiérrez Herrero, Sara ^a   Maia, Vera ^a   Gutiérrez Berzal, Javier ^a   Calzada, Nuria ^a   Sanz, María ^a   González Manchón, Consuelo ^b,g   Pericacho, Miguel ^b,g   Ortiz Rivero, Sara ^a   González Porras, José R ^c,f   Arechederra, María ^d,h   Porras, Almudena ^d,h   Guerrero, Carmen ^a,e,f  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^d HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^e UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^f HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^g UNIVERSITY OF SALAMANCA   (Spain)

^h INSTITUTO DE INVESTIGACIÓN BIOMÉDICA DE SALAMANCA IBSAL   (Spain)

Author keywords

C3G; Granulocyte; Neutrophil; Platelet; Rap1; Transgenic mice

Indexed keywords

RAP1 PROTEIN; THROMBIN; THROMBOCYTE FACTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING TENDENCY; BLEEDING TIME; BLOOD; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENOTYPE; IN VITRO STUDY; IN VIVO STUDY; MALE; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; THROMBOCYTE AGGREGATION; TRANSGENIC MOUSE;

ANIMALS; BLOOD PLATELETS; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; GENETIC ENGINEERING; GUANINE NUCLEOTIDE-RELEASING FACTOR 2; HUMANS; LEUKOCYTE COUNT; MALE; MEGAKARYOCYTES; MICE; MICE, TRANSGENIC; NEUTROPHILS; PLATELET ACTIVATION; PLATELET COUNT; PLATELET FACTOR 4; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C; RAP1 GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 84862291177     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.05.021     Document Type: Article

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