Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K2P channels

Neuron

Volumn 84, Issue 6, 2014, Pages 1198-1212

  Lolicato, Marco ^a   Riegelhaupt, Paul M ^a,b   Arrigoni, Cristina ^a   Clark, Kimberly A ^a   Minor, Daniel L ^a,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; MUTANT PROTEIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL K2P4.1; UNCLASSIFIED DRUG; KCNK4 PROTEIN, HUMAN; LIPID BILAYER;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; HEAT SENSITIVITY; HYDROPHOBICITY; LIPID BILAYER; M2 TRANSMEMBRANE HELIX; M4 INNER TRANSMEMBRANE HELIX; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; ANIMAL; CELL CULTURE; CELL MEMBRANE; CHEMISTRY; GENETICS; METABOLISM; MUTATION; OOCYTE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; STIMULATION; TEMPERATURE; XENOPUS LAEVIS;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; ION CHANNEL GATING; LIPID BILAYERS; MUTATION; OOCYTES; PHYSICAL STIMULATION; POTASSIUM CHANNELS; PROTEIN STRUCTURE, SECONDARY; TEMPERATURE; XENOPUS LAEVIS;

EID: 84926368897     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.11.017     Document Type: Article

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