A novel mechanism for human K2P2.1 channel gating: Facilitation of C-type gating by protonation of extracellular histidine residues

Journal of Biological Chemistry

Volumn 283, Issue 28, 2008, Pages 19448-19455

  Cohen, Asi ^a   Ben Abu, Yuval ^a   Hen, Shelly ^a   Zilberberg, Noam ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; HYDROGEN; HYDROGEN BONDS; MAMMALS; PROTONATION; PROTONS;

CELLULAR MECHANISMS; CHANNEL GATING; EXTERNAL-; EXTRACELLULAR; HISTIDINE RESIDUES; NATURAL INTERACTIONS; NEGATIVE POTENTIALS; NEUROPROTECTION; OPEN CONFORMATIONS; PAIN PERCEPTIONS; PH SENSING; PHYSICAL PROXIMITIES; PHYSIOLOGICAL RANGES; POSITIVE CHARGES; POTASSIUM CHANNELS; POTASSIUM IONS; SELECTIVITY FILTERS;

ELECTRIC RECTIFIERS;

GLUTAMIC ACID; HISTIDINE; POTASSIUM CHANNEL; POTASSIUM ION; PROTON; SHAKER POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; POTASSIUM CHANNEL PROTEIN TREK 1; POTASSIUM CHANNEL PROTEIN TREK-1; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ACIDIFICATION; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CELL PH; CHANNEL GATING; CONFORMATION; EXTRACELLULAR SPACE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTON TRANSPORT; TRANSPORT KINETICS; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; DEPRESSION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PAIN; PH; PROTEIN SECONDARY STRUCTURE; XENOPUS LAEVIS;

MAMMALIA;

ANIMALS; DEPRESSION; FEMALE; GENE EXPRESSION REGULATION; HISTIDINE; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; ORGAN SPECIFICITY; PAIN; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN STRUCTURE, SECONDARY; PROTONS; XENOPUS LAEVIS;

EID: 50349097381     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801273200     Document Type: Article

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