Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 6, 2013, Pages 2129-2134

  Brohawn, Stephen G ^a   Campbell, Ernest B ^a   MacKinnon, Roderick ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Ion channel gating; Mechanosensitivity; Two pore domain potassium channel

Indexed keywords

POTASSIUM CHANNEL; TWIK RELATED ARACHIDONIC ACID STIMULATED POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CELL MEMBRANE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CROSS LINKING; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; HUMAN CELL; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE;

ANTIBODIES, MONOCLONAL; BIOPHYSICAL PHENOMENA; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; ION CHANNEL GATING; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; POTASSIUM CHANNELS; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS;

EID: 84873464614     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218950110     Document Type: Article

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