State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

Channels

Volumn 6, Issue 6, 2012, Pages 473-478

  Rapedius, Markus ^a   Schmidt, Matthias R ^b,c   Sharma, Chetan ^c   Stansfeld, Phillip J ^b   Sansom, Mark S P ^b,c   Baukrowitz, Thomas ^a   Tucker, Stephen J ^c  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Docking; Homology modeling; Ion channel; K2P channel; Potassium channel; TRAAK; TREK 1; TWIK 1

Indexed keywords

POTASSIUM CHANNEL; PROTEIN TREK 1; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CYTOPLASM; PROTEIN BINDING; PROTEIN STRUCTURE;

EID: 84871438402     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.22153     Document Type: Article

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