The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs

International Journal of Molecular Sciences

Volumn 16, Issue 3, 2015, Pages 6545-6556

  Feng, Wanyou ^a   Dai, Yifan ^b   Mou, Lisha ^a   Cooper, David K C ^c   Shi, Deshun ^d   Cai, Zhiming ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d GUANGXI UNIVERSITY   (China)

Author keywords

Chimaeric; CRISPR Cas9; Genome editing; IPSC; Pigs; Xenotransplantation

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN 9; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE; ENDONUCLEASE;

CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DNA MODIFICATION; GENE DELETION; GENETIC ENGINEERING; HUMAN; IMMUNE RESPONSE; NONHUMAN; ORGAN TRANSPLANTATION; PLURIPOTENT STEM CELL; REVIEW; SWINE; TRANSGENIC ANIMAL; XENOTRANSPLANTATION; ANIMAL; METABOLISM; PHYSIOLOGY; PIG;

SUIDAE;

ANIMALS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; ENDONUCLEASES; HUMANS; PLURIPOTENT STEM CELLS; SWINE;

EID: 84925862629     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16036545     Document Type: Review

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