메뉴 건너뛰기




Volumn 41, Issue 12, 2015, Pages 970-974

Creating human organs in chimaera pigs: An ethical source of immunocompatible organs?

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANIMAL WELFARE; CHIMERA; HUMAN DIGNITY; HUMAN VERSUS ANIMAL COMPARISON; NONHUMAN; ORGAN; PIG; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; TRANSPLANTATION; ANIMAL; ETHICS; GRAFT REJECTION; HISTOCOMPATIBILITY; HOSPITAL ADMISSION; HUMAN; IMMUNOLOGY; INDUCED PLURIPOTENT STEM CELL; ORGAN TRANSPLANTATION; PERSONHOOD; PROCEDURES; TRANSPLANTATION TOLERANCE; TRENDS; ZOONOSES;

EID: 84949996967     PISSN: 03066800     EISSN: 14734257     Source Type: Journal    
DOI: 10.1136/medethics-2014-102224     Document Type: Article
Times cited : (24)

References (23)
  • 1
    • 84888996948 scopus 로고    scopus 로고
    • UK: NHS Blood and Transplant, (accessed 6 May 13)
    • Organ Donation. UK: NHS Blood and Transplant. http://www.organdonation.nhs.uk/ (accessed 6 May 13).
    • Organ Donation
  • 3
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 4
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007;448:313-17.
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 5
    • 39149086020 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from fibroblast cultures
    • Takahashi K, Okita K, Nakagawa M. et al. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2007;2:3081-9.
    • (2007) Nat Protoc , vol.2 , pp. 3081-3089
    • Takahashi, K.1    Okita, K.2    Nakagawa, M.3
  • 6
    • 84874353977 scopus 로고    scopus 로고
    • Stem cells cruise to clinic
    • Cyranoski D. Stem cells cruise to clinic. Nature 2013;494:413.
    • (2013) Nature , vol.494 , pp. 413
    • Cyranoski, D.1
  • 7
    • 84949984087 scopus 로고    scopus 로고
    • Historic Japan Stem Cell Trial Approved
    • 14 Aug 2013
    • Fox C. Historic Japan Stem Cell Trial Approved. Bioscience Technology, 14 Aug 2013. http://www.biosciencetechnology.com/articles/2013/08/historic-japan-stem-cell-trial-approved#.UrQfgGQXRhQ
    • Bioscience Technology
    • Fox, C.1
  • 8
    • 84867572157 scopus 로고    scopus 로고
    • Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application
    • Takayama N, Eto K. Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application. Cell Mol Life Sci 2012;69:3419-28.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 3419-3428
    • Takayama, N.1    Eto, K.2
  • 9
    • 84555190128 scopus 로고    scopus 로고
    • In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells
    • Takayama N, Eto K. In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells. Methods Mol Biol 2012;788:205-17.
    • (2012) Methods Mol Biol , vol.788 , pp. 205-217
    • Takayama, N.1    Eto, K.2
  • 10
    • 78650352754 scopus 로고    scopus 로고
    • Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells
    • Takayama N, Nishimura S, Nakamura S. et al. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med 2010;207:2817-30.
    • (2010) J Exp Med , vol.207 , pp. 2817-2830
    • Takayama, N.1    Nishimura, S.2    Nakamura, S.3
  • 11
    • 77956163474 scopus 로고    scopus 로고
    • Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells
    • Kobayashi T, Yamaguchi T, Hamanaka S. et al. Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells. Cell 2010;142:787-99.
    • (2010) Cell , vol.142 , pp. 787-799
    • Kobayashi, T.1    Yamaguchi, T.2    Hamanaka, S.3
  • 12
    • 79953012716 scopus 로고    scopus 로고
    • Formation of a thymus from rat ES cells in xenogeneic nude mouse<-->rat ES chimeras
    • Isotani A, Hatayama H, Kaseda K, et al. Formation of a thymus from rat ES cells in xenogeneic nude mouse<-->rat ES chimeras. Genes Cells 2011;16:397-405.
    • (2011) Genes Cells , vol.16 , pp. 397-405
    • Isotani, A.1    Hatayama, H.2    Kaseda, K.3
  • 13
    • 0020209562 scopus 로고
    • Interspecific chimeras in mammals: a new experimental system
    • Rossant J, Croy BA, Chapman VM, et al. Interspecific chimeras in mammals: a new experimental system. J Anim Sci 1982;55:1241-8.
    • (1982) J Anim Sci , vol.55 , pp. 1241-1248
    • Rossant, J.1    Croy, B.A.2    Chapman, V.M.3
  • 14
    • 84875252985 scopus 로고    scopus 로고
    • Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs
    • Matsunari H, Nagashima H, Watanabe M, et al. Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc Natl Acad Sci USA 2013;110:4557-62.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 4557-4562
    • Matsunari, H.1    Nagashima, H.2    Watanabe, M.3
  • 15
    • 84949953560 scopus 로고    scopus 로고
    • Proceedings of the International Conference on Chimera Organs. Utrecht, 4.12.13
    • Proceedings of the International Conference on Chimera Organs. Utrecht, 4.12.13.
  • 16
    • 84890439421 scopus 로고    scopus 로고
    • Derivation of novel human ground state naive pluripotent stem cells
    • Gafni O, Weinberger L, Mansour AA, et al. Derivation of novel human ground state naive pluripotent stem cells. Nature 2013;504(7479):282-6.
    • (2013) Nature , vol.504 , Issue.7479 , pp. 282-286
    • Gafni, O.1    Weinberger, L.2    Mansour, A.A.3
  • 17
    • 84908505807 scopus 로고    scopus 로고
    • Using Non-Human Primates to benefit humans: Research and Organ Transplantation
    • Shaw D, Dondorp W, de Wert G. Using Non-Human Primates to benefit humans: Research and Organ Transplantation. Med Health Care Philos 2014;17:573-8.
    • (2014) Med Health Care Philos , vol.17 , pp. 573-578
    • Shaw, D.1    Dondorp, W.2    de Wert, G.3
  • 19
    • 34447322542 scopus 로고    scopus 로고
    • The demise of UKXIRA and the regulation of solid-organ xenotransplantation in the UK
    • McLean S, Williamson L. The demise of UKXIRA and the regulation of solid-organ xenotransplantation in the UK. J Med Ethics 2007;33(7):373-5.
    • (2007) J Med Ethics , vol.33 , Issue.7 , pp. 373-375
    • McLean, S.1    Williamson, L.2
  • 20
    • 85012504336 scopus 로고    scopus 로고
    • Crossing species boundaries
    • Robert JS, Baylis F. Crossing species boundaries. Am J Bioeth 2003;3(3):1-13.
    • (2003) Am J Bioeth , vol.3 , Issue.3 , pp. 1-13
    • Robert, J.S.1    Baylis, F.2
  • 21
    • 80053415012 scopus 로고    scopus 로고
    • Animals containing human material
    • (accessed 6/5/13)
    • Academy of Medical Sciences. Animals containing human material. 2011. http://www.acmedsci.ac.uk/p47prid77.html#downloads (accessed 6/5/13).
    • (2011)
  • 22
    • 84949958333 scopus 로고    scopus 로고
    • Chimeras are a shocking affront to human dignity
    • 14 Sep 2007, (accessed 6 May 13)
    • Chimeras are a shocking affront to human dignity. Catholic Herald, 14 Sep 2007. http://archive.catholicherald.co.uk/article/14th-september-2007/11/chimeras-are-a-shocking-affront-to-human-dignity (accessed 6 May 13)
    • Catholic Herald
  • 23
    • 84949941132 scopus 로고    scopus 로고
    • File 34: Chimeras, hybrids and 'cybrids'
    • (accessed 6 May 13)
    • MacKellar C. File 34: Chimeras, hybrids and 'cybrids'. Christian Medical Fellowship, 2007. http://admin.cmf.org.uk/pdf/cmffiles/34_hybrids.pdf (accessed 6 May 13).
    • (2007) Christian Medical Fellowship
    • MacKellar, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.