A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 8, 2015, Pages 1828-1840

  Carta, Fabrizio ^a   Di Cesare Mannelli, Lorenzo ^a   Pinard, Melissa ^b   Ghelardini, Carla ^a   Scozzafava, Andrea ^a   McKenna, Robert ^b   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Analgesic; Carbonic anhydrase; Metalloenzyme; Pain; Sulfonamide; X ray crystallography

Indexed keywords

4 (2' MORPHOLINOETHOXY)BENZENESULFONAMIDE; 4 (2',2' DIPHENYLETHOXY)BENZENESULFONAMIDE; 4 (3' PHENYLPROP 2' YNYLOXY)BENZENESULFONAMIDE; 4 (4' FLUOROBENZYLOXY)BENZENESULFONAMIDE; 4 (4' NITROBENZYLOXY)BENZENESULFONAMIDE; 4 (5' BROMOBENZYLOXY)BENZENESULFONAMIDE; 4 (ALLYLOXY)BENZENESULFONAMIDE; 4 (BENZYLOXY)BENZENESULFONAMIDE; 4 (DIPROP 2' YNYLAMINO)BENZENESULFONAMIDE; 4 (DIPROP 2' YNYLAMINO)BENZENESULFONAMIDEHEXACARBONYLDICOBALT; 4 (PERFLUOROBENZYLOXY)BENZENESULFONAMIDE; 4 (PROP 2' YNYLOXY)BENZENESULFONAMIDE; 4 (PROP 2' YNYLOXY)BENZENESULFONAMIDEHEXACARBONYLDICOBALT; 4 ETHOXYBENZENESULFONAMIDE; 4 N BUTOXYBENZENESULFONAMIDE; 4 N PROPOXYBENZENESULFONAMIDE; 4 PHENETHOXYBENZENESULFONAMIDE; 6 (3' PHENYLPROP 2' YNYLOXY)BENZO[D]THIAZOLE 2 SULFONAMIDE; 6 (BENZYLOXY)BENZO[D]THIAZOLE 2 SULFONAMIDE; ACETAZOLAMIDE; ANALGESIC AGENT; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; CELECOXIB; OXALIPLATIN; SULFONAMIDE CARBONIC ANHYDRASE INHIBITOR DERIVATIVE; UNCLASSIFIED DRUG; SULFONAMIDE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; NEURALGIA;

MUS;

ANALGESICS; ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MICE; MODELS, MOLECULAR; NEURALGIA; SULFONAMIDES;

EID: 84925674085     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.02.027     Document Type: Article

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