Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 8, 2008, Pages 2669-2674

  Di Fiore, Anna ^a   Pedone, Carlo ^a   Antel, Jochen ^b   Waldeck, Harald ^b   Witte, Andreas ^b   Wurl, Michael ^b   Scozzafava, Andrea ^c   Supuran, Claudiu T ^c   De Simone, Giuseppina ^a  

^a CNR   (Italy)

^b Solvay Pharmaceuticals GmbH   (Germany)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic Anhydrase; Ethoxzolamide; Protein crystallography

Indexed keywords

ANTIGLAUCOMA AGENT; BRINZOLAMIDE; CARBONATE DEHYDRATASE INHIBITOR; DORZOLAMIDE; ETHOXZOLAMIDE; GLUTAMINE; ISOENZYME; THREONINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOSOL; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME INHIBITION; MAMMAL; MOLECULE; NONHUMAN; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ETHOXZOLAMIDE; GLUTAMINE; HUMANS; ISOENZYMES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; THREONINE;

MAMMALIA;

EID: 41849144143     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.023     Document Type: Article

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