Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: Structure-based drug design, synthesis, and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3307-3319

  Vernier, William ^a   Chong, Wesley ^a   Rewolinski, David ^a   Greasley, Samantha ^a   Pauly, Thomas ^a   Shaw, Morena ^a   Dinh, Dac ^a   Ferre, Rose Ann ^a   Nukui, Seiji ^a   Ornelas, Martha ^a   Reyner, Eric ^a  

^a PFIZER INC   (United States)

Author keywords

Carbonic anhydrase; Glaucoma; Thioether benzenesulfonamide

Indexed keywords

5 (AMINOSULFONYL) 2 (CYCLOPENTYLTHIO) N ETHYLBENZAMIDE; 5 (AMINOSULFONYL) 2 (PHENYLTHIO) N (PYRIDIN 2 YLMETHYL)BENZAMIDE; 5 (AMINOSULFONYL) 2 (PHENYLTHIO)NICOTINATE ETHYL ESTER; 5 (AMINOSULFONYL) 2 [(2,3,5,6 TETRAFLUOROPHENYL)THIO]NICOTINATE ETHYL ESTER; 5 (AMINOSULFONYL) 2 [(3,4 DIFLUOROPHENYL)THIO]NICOTINATE ETHYL ESTER; 5 (AMINOSULFONYL) 2 [[2 (HYDROXYMETHYL)PHENYL]THIO] N (PYRIDIN 2 YLMETHYL)BENZAMIDE; 5 (AMINOSULFONYL) 2 CHLORO N (PYRIDIN 2 YLMETHYL)NICOTINAMIDE; 5 (AMINOSULFONYL) 2 CHLORO N ETHYLNICOTINAMIDE; 5 (AMINOSULFONYL) 2 CHLORONICOTINATE ETHYL ESTER; 5 (AMINOSULFONYL) 2 FLUORO N (2 METHOXYETHYL)BENZAMIDE; 5 (AMINOSULFONYL) 2 FLUORO N (PYRIDIN 2 YLMETHYL)BENZAMIDE; 5 (AMINOSULFONYL) 2 FLUOROBENZOIC ACID; 5 (AMINOSULFONYL) N (2 METHOXYETHYL) 2 (PHENYLTHIO)NICOTINAMIDE; 5 (AMINOSULFONYL) N (2 METHOXYETHYL) 2 [(2 PHENYL ETHYL)THIO]BENZAMIDE; 5 (AMINOSULFONYL) N (PYRIDIN 2 YLMETHYL) 2 (PYRIDIN 1 YLTHIO)BENZAMIDE; 5 (AMINOSULFONYL) N [2 (DIMETHYLAMINO)ETHYL] 2 (PHENYLTHIO)NICOTINAMIDE; 5 (AMINOSULFONYL) N BENZYL 2 (PHENYLSULFONYL)BENZAMIDE; 5 (AMINOSULFONYL) N BENZYL 2 (PHENYLTHIO)BENZAMIDE; 5 (AMINOSULFONYL) N BENZYL 2 FLUOROBENZAMIDE; 5 (AMINOSULFONYL) N BENZYL 2 PHENOXYBENZAMIDE; 5 (AMINOSULFONYL) N ETHYL 2 (PHENYLTHIO)BENZAMIDE; 5 (AMINOSULFONYL) N ETHYL 2 (PHENYLTHIO)NICOTINAMIDE; 5 (AMINOSULFONYL) N ETHYL 2 FLUOROBENZAMIDE; 5 (AMINOSULFONYL) N ISOBUTYL 2 (ISOPROPYLTHIO)BENZAMIDE; CARBONATE DEHYDRATASE II INHIBITOR; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IV INHIBITOR; DORZOLAMIDE; THIOETHER BENZENESULFONAMIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CILIARY BODY; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IRIS; NONHUMAN; PHYSICAL CHEMISTRY; RABBIT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; TISSUE HOMOGENATE;

ANIMALS; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; SULFONAMIDES;

ORYCTOLAGUS CUNICULUS;

EID: 77951204369     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.014     Document Type: Article

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