Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1560-1564

  Truppo, Emanuela ^a   Supuran, Claudiu T ^b   Sandomenico, Annamaria ^a   Vullo, Daniela ^b   Innocenti, Alessio ^b   Di Fiore, Anna ^a   Alterio, Vincenzo ^a   De Simone, Giuseppina ^a   Monti, Simona M ^a  

^a CNR   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

CA inhibitors; Carbonic anhydrase VII; Catalytic activity; Cysteine reactivity; Glutathionylation

Indexed keywords

ACETAZOLAMIDE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CARBONIC ANHYDRASE VII; CYSTEINE; ESTERASE; GLUTATHIONE TRANSFERASE; OXYGEN; PHOSPHATASE; SCAVENGER; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME MODIFICATION; HUMAN; HUMAN CELL; HYDRATION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT;

EID: 84856650479     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.134     Document Type: Article

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