A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol

Nature

Volumn 519, Issue 7543, 2015, Pages 370-373

  Sajish, Mathew ^a   Schimmel, Paul ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN P53; RESVERATROL; TYROSINE TRANSFER RNA LIGASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); SERUM-FREE MEDIUM; SIRT1 PROTEIN, HUMAN; SIRT6 PROTEIN, HUMAN; SIRTUIN; SIRTUIN 1; STILBENE DERIVATIVE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CATALYSIS; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION CONSTANT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOCATALYSIS; CELL NUCLEUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION; SERUM-FREE MEDIUM; X RAY CRYSTALLOGRAPHY;

ALTERNATIVE SPLICING; ANIMALS; BIOCATALYSIS; CATALYTIC DOMAIN; CELL NUCLEUS; CRYSTALLOGRAPHY, X-RAY; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; HUMANS; MALE; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; SIRTUIN 1; SIRTUINS; STILBENES; TYROSINE-TRNA LIGASE;

EID: 84925503952     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14028     Document Type: Article

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