메뉴 건너뛰기




Volumn 8, Issue 6, 2012, Pages 547-554

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; GAMMA INTERFERON; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN P53; TRYPTOPHAN TRANSFER RNA LIGASE;

EID: 84861337799     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.937     Document Type: Review
Times cited : (78)

References (44)
  • 1
    • 70349545940 scopus 로고    scopus 로고
    • Aminoacyl-tRNA synthesis and translational quality control
    • Ling, J., Reynolds, N. & Ibba, M. Aminoacyl-tRNA synthesis and translational quality control. Annu. Rev. Microbiol. 63, 61-78 (2009).
    • (2009) Annu. Rev. Microbiol. , vol.63 , pp. 61-78
    • Ling, J.1    Reynolds, N.2    Ibba, M.3
  • 2
    • 0027255483 scopus 로고
    • Cognition mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases
    • Carter, C.W. Jr. Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases. Annu. Rev. Biochem. 62, 715-748 (1993).
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 715-748
    • Carter Jr., C.W.1
  • 3
    • 0025158208 scopus 로고
    • Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs
    • Eriani, G., Delarue, M., Poch, O., Gangloff, J. & Moras, D. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature 347, 203-206 (1990).
    • (1990) Nature , vol.347 , pp. 203-206
    • Eriani, G.1    Delarue, M.2    Poch, O.3    Gangloff, J.4    Moras, D.5
  • 4
    • 0026348958 scopus 로고
    • Human Interferon γ potently induces the synthesis of a 55-kDa protein (γ2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase
    • Fleckner, J., Rasmussen, H.H. & Justesen, J. Human interferon γ potently induces the synthesis of a 55-kDa protein (γ2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase. Proc. Natl. Acad. Sci. USA 88, 11520-11524 (1991). (Pubitemid 21916073)
    • (1991) Proceedings of the National Academy of Sciences of the United States of America , vol.88 , Issue.24 , pp. 11520-11524
    • Fleckner, J.1    Rasmussen, H.H.2    Justesen, J.3
  • 5
    • 0026343599 scopus 로고
    • Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts
    • Rubin, B.Y., Anderson, S.L., Xing, L., Powell, R.J. & Tate, W.P. Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts. J. Biol. Chem. 266, 24245-24248 (1991). (Pubitemid 21908932)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.36 , pp. 24245-24248
    • Rubin, B.Y.1    Anderson, S.L.2    Xing, L.3    Powell, R.J.4    Tate, W.P.5
  • 6
    • 0026554345 scopus 로고
    • An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase
    • Bange, F.C., Flohr, T., Buwitt, U. & Bottger, E.C. An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase. FEBS Lett. 300, 162-166 (1992).
    • (1992) FEBS Lett. , vol.300 , pp. 162-166
    • Bange, F.C.1    Flohr, T.2    Buwitt, U.3    Bottger, E.C.4
  • 7
    • 33846554389 scopus 로고    scopus 로고
    • IFITM1 plays an essential role in the antiproliferative action of interferon-γ
    • DOI 10.1038/sj.onc.1209807, PII 1209807
    • Yang, G., Xu, Y., Chen, X. & Hu, G. IFITM1 plays an essential role in the antiproliferative action of interferon-γ. Oncogene 26, 594-603 (2007). (Pubitemid 46160972)
    • (2007) Oncogene , vol.26 , Issue.4 , pp. 594-603
    • Yang, G.1    Xu, Y.2    Chen, X.3    Hu, G.4
  • 8
    • 0036835864 scopus 로고    scopus 로고
    • Interferons as antiangiogenic agents
    • Lindner, D.J. Interferons as antiangiogenic agents. Curr. Oncol. Rep. 4, 510-514 (2002).
    • (2002) Curr. Oncol. Rep. , vol.4 , pp. 510-514
    • Lindner, D.J.1
  • 9
    • 59049088856 scopus 로고    scopus 로고
    • Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells
    • Kim, K.S., Kang, K.W., Seu, Y.B., Baek, S.H. & Kim, J.R. Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells. Mech. Ageing Dev. 130, 179-188 (2009).
    • (2009) Mech. Ageing Dev. , vol.130 , pp. 179-188
    • Kim, K.S.1    Kang, K.W.2    Seu, Y.B.3    Baek, S.H.4    Kim, J.R.5
  • 11
    • 0029031790 scopus 로고
    • Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo
    • Angiolillo, A.L. et al. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182, 155-162 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 155-162
    • Angiolillo, A.L.1
  • 13
    • 38349175950 scopus 로고    scopus 로고
    • Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS
    • Kapoor, M. et al. Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS. J. Biol. Chem. 283, 2070-2077 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 2070-2077
    • Kapoor, M.1
  • 14
    • 77449125916 scopus 로고    scopus 로고
    • Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality
    • Zhou, Q. et al. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality. Nat. Struct. Mol. Biol. 17, 57-61 (2010).
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 57-61
    • Zhou, Q.1
  • 15
    • 77956095201 scopus 로고    scopus 로고
    • New functions of aminoacyl-tRNA synthetases beyond translation
    • Guo, M., Yang, X.L. & Schimmel, P. New functions of aminoacyl-tRNA synthetases beyond translation. Nat. Rev. Mol. Cell Biol. 11, 668-674 (2010).
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 668-674
    • Guo, M.1    Yang, X.L.2    Schimmel, P.3
  • 17
    • 66449115592 scopus 로고    scopus 로고
    • LysRS serves as a key signaling molecule in the immune response by regulating gene expression
    • Yannay-Cohen, N. et al. LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Mol. Cell 34, 603-611 (2009).
    • (2009) Mol. Cell , vol.34 , pp. 603-611
    • Yannay-Cohen, N.1
  • 19
    • 0024369173 scopus 로고
    • Immune electron microscope determination of the localization of tryptophanyl-tRNA-synthetase in bacteria and higher eukaryotes
    • Popenko, V.I., Cherni, N.E., Beresten, S.F., Zargarova, T.A. & Favorova, O.O. Immune electron microscope determination of the localization of tryptophanyl-tRNA-synthetase in bacteria and higher eukaryotes. Mol. Biol. (Mosk.) 23, 1669-1681 (1989).
    • (1989) Mol. Biol. (Mosk.) , vol.23 , pp. 1669-1681
    • Popenko, V.I.1    Cherni, N.E.2    Beresten, S.F.3    Zargarova, T.A.4    Favorova, O.O.5
  • 20
    • 34447307157 scopus 로고    scopus 로고
    • Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase
    • Yang, X.L. et al. Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase. Structure 15, 793-805 (2007).
    • (2007) Structure , vol.15 , pp. 793-805
    • Yang, X.L.1
  • 21
    • 33745529250 scopus 로고    scopus 로고
    • Two conformations of a crystalline human tRNA synthetase-tRNA complex: Implications for protein synthesis
    • Yang, X.L. et al. Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. EMBO J. 25, 2919-2929 (2006).
    • (2006) EMBO J. , vol.25 , pp. 2919-2929
    • Yang, X.L.1
  • 22
    • 1342327657 scopus 로고    scopus 로고
    • A new γ-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase
    • DOI 10.1093/nar/gkh240
    • Liu, J., Shue, E., Ewalt, K.L. & Schimmel, P. A new γ-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase. Nucleic Acids Res. 32, 719-727 (2004). (Pubitemid 38263063)
    • (2004) Nucleic Acids Research , vol.32 , Issue.2 , pp. 719-727
    • Liu, J.1    Shue, E.2    Ewalt, K.L.3    Schimmel, P.4
  • 23
    • 73849140503 scopus 로고    scopus 로고
    • Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
    • Sibanda, B.L., Chirgadze, D.Y. & Blundell, T.L. Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature 463, 118-121 (2010).
    • (2010) Nature , vol.463 , pp. 118-121
    • Sibanda, B.L.1    Chirgadze, D.Y.2    Blundell, T.L.3
  • 26
    • 35548969432 scopus 로고    scopus 로고
    • DNA-dependent protein kinase in nonhomologous end joining: A lock with multiple keys?
    • DOI 10.1083/jcb.200705106
    • Weterings, E. & Chen, D.J. DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J. Cell Biol. 179, 183-186 (2007). (Pubitemid 350004882)
    • (2007) Journal of Cell Biology , vol.179 , Issue.2 , pp. 183-186
    • Weterings, E.1    Chen, D.J.2
  • 27
    • 0030771841 scopus 로고    scopus 로고
    • Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit
    • DOI 10.1074/jbc.272.40.24763
    • Jin, S., Kharbanda, S., Mayer, B., Kufe, D. & Weaver, D.T. Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. J. Biol. Chem. 272, 24763-24766 (1997). (Pubitemid 27415644)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.40 , pp. 24763-24766
    • Jin, S.1    Kharbanda, S.2    Mayer, B.3    Kufe, D.4    Weaver, D.T.5
  • 28
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • Lees-Miller, S.P., Sakaguchi, K., Ullrich, S.J., Appella, E. & Anderson, C.W. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell. Biol. 12, 5041-5049 (1992).
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 29
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • DOI 10.1038/29343
    • Woo, R.A., McLure, K.G., Lees-Miller, S.P., Rancourt, D.E. & Lee, P.W. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394, 700-704 (1998). (Pubitemid 28389800)
    • (1998) Nature , vol.394 , Issue.6694 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.K.5
  • 30
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • DOI 10.1016/S0092-8674(00)80416-X
    • Shieh, S.Y., Ikeda, M., Taya, Y. & Prives, C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334 (1997). (Pubitemid 27467963)
    • (1997) Cell , vol.91 , Issue.3 , pp. 325-334
    • Shieh, S.-Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 32
    • 33747619857 scopus 로고    scopus 로고
    • P53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase
    • DOI 10.1126/science.1126391
    • Teodoro, J.G., Parker, A.E., Zhu, X. & Green, M.R. p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. Science 313, 968-971 (2006). (Pubitemid 44267388)
    • (2006) Science , vol.313 , Issue.5789 , pp. 968-971
    • Teodoro, J.G.1    Parker, A.E.2    Zhu, X.3    Green, M.R.4
  • 33
    • 33748545328 scopus 로고    scopus 로고
    • An Active Dominant Mutation of Glycyl-tRNA Synthetase Causes Neuropathy in a Charcot-Marie-Tooth 2D Mouse Model
    • DOI 10.1016/j.neuron.2006.08.027, PII S0896627306006738
    • Seburn, K.L., Nangle, L.A., Cox, G.A., Schimmel, P. & Burgess, R.W. An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model. Neuron 51, 715-726 (2006). (Pubitemid 44374911)
    • (2006) Neuron , vol.51 , Issue.6 , pp. 715-726
    • Seburn, K.L.1    Nangle, L.A.2    Cox, G.A.3    Schimmel, P.4    Burgess, R.W.5
  • 34
    • 55949096610 scopus 로고    scopus 로고
    • Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines
    • Grueneberg, D.A. et al. Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines. Proc. Natl. Acad. Sci. USA 105, 16490-16495 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16490-16495
    • Grueneberg, D.A.1
  • 36
    • 78650644912 scopus 로고    scopus 로고
    • In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish
    • Aggad, D. et al. In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish. J. Immunol. 185, 6774-6782 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 6774-6782
    • Aggad, D.1
  • 37
  • 39
    • 0037439071 scopus 로고    scopus 로고
    • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the brca1 full-length isoform
    • DOI 10.1101/gad.1050003
    • Cao, L., Li, W., Kim, S., Brodie, S.G. & Deng, C.X. Senescence, aging and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev. 17, 201-213 (2003). (Pubitemid 36105893)
    • (2003) Genes and Development , vol.17 , Issue.2 , pp. 201-213
    • Cao, L.1    Li, W.2    Kim, S.3    Brodie, S.G.4    Deng, C.-X.5
  • 40
    • 50849120727 scopus 로고    scopus 로고
    • The identification of zebrafish mutants showing alterations in senescence-associated biomarkers
    • Kishi, S. et al. The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet. 4, e1000152 (2008).
    • (2008) PLoS Genet. , vol.4
    • Kishi, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.