tRNA-controlled nuclear import of a human tRNA synthetase

Journal of Biological Chemistry

Volumn 287, Issue 12, 2012, Pages 9330-9334

  Fu, Guangsen ^a   Xu, Tao ^a   Shi, Yi ^a   Wei, Na ^a   Yang, Xiang Lei ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOACYLATION; ANTICODONS; BIOINFORMATICS ANALYSIS; ESSENTIAL COMPONENT; LOWER EUKARYOTES; NUCLEAR DISTRIBUTION; NUCLEAR FUNCTION; NUCLEAR IMPORT; NUCLEAR LOCALIZATION; NUCLEAR LOCALIZATION SIGNAL; PROTEIN SYNTHESIS; SEQUENCE MOTIFS; SYNTHETASES;

AMINO ACIDS; BIOINFORMATICS;

CYTOLOGY;

AMINO ACID TRANSFER RNA LIGASE; TRANSFER RNA;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANTICODON; CELL NUCLEUS; CRYSTALLOGRAPHY, X-RAY; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RNA, TRANSFER, AMINO ACYL; TYROSINE-TRNA LIGASE;

EUKARYOTA;

EID: 84863357487     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C111.325902     Document Type: Article

References (22)

1. Carter, C. W., Jr. (1993) Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases. Annu. Rev. Biochem. 62, 715-748
2. Giegé, R. (2006) The early history of tRNA recognition by aminoacyltRNA synthetases. J. Biosci. 31, 477-488
3. Nathanson, L., and Deutscher, M. P. (2000) Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex. J. Biol. Chem. 275, 31559-31562
4. Popenko, V. I., Ivanova, J. L., Cherny, N. E., Filonenko, V. V., Beresten, S. F., Wolfson, A. D., and Kisselev, L. L. (1994) Compartmentalization of certain components of the protein synthesis apparatus in mammalian cells. Eur. J. Cell Biol. 65, 60-69 (Pubitemid 24328178)
5. Lund, E., and Dahlberg, J. E. (1998) Proofreading and aminoacylation of tRNAs before export from the nucleus. Science 282, 2082-2085 (Pubitemid 29001264)
6. Sarkar, S., Azad, A. K., and Hopper, A. K. (1999) Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 96, 14366-14371 (Pubitemid 30000656)
7. Grosshans, H., Hurt, E., and Simos, G. (2000) An aminoacylation-dependent nuclear tRNA export pathway in yeast. Genes Dev. 14, 830-840 (Pubitemid 30215002)
8. Yannay-Cohen, N., Carmi-Levy, I., Kay, G., Yang, C. M., Han, J. M., Kemeny, D. M., Kim, S., Nechushtan, H., and Razin, E. (2009) LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Mol. Cell 34, 603-611
9. Ko, Y. G., Kang, Y. S., Kim, E. K., Park, S. G., and Kim, S. (2000) Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. J. Cell Biol. 149, 567-574 (Pubitemid 30252391)
10. Wakasugi, K., and Schimmel, P. (1999) Two distinct cytokines released from a human aminoacyl-tRNA synthetase. Science 284, 147-151 (Pubitemid 29282068)
11. Jordanova, A., Irobi, J., Thomas, F. P., Van Dijck, P., Meerschaert, K., Dewil, M., Dierick, I., Jacobs, A., De Vriendt, E., Guergueltcheva, V., Rao, C. V., Tournev, I., Gondim, F. A., D'Hooghe, M., Van Gerwen, V., Callaerts, P., Van Den Bosch, L., Timmermans, J. P., Robberecht, W., Gettemans, J., Thevelein, J. M., De Jonghe, P., Kremensky, I., and Timmerman, V. (2006) Disrupted function and axonal distribution of mutant tyrosyltRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat. Genet. 38, 197-202 (Pubitemid 43177233)
12. Azad, A. K., Stanford, D. R., Sarkar, S., and Hopper, A. K. (2001) Role of nuclear pools of aminoacyl-tRNA synthetases in tRNA nuclear export. Mol. Biol. Cell 12, 1381-1392 (Pubitemid 33044418)
13. Shenoy, A. R., and Visweswariah, S. S. (2003) Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA. Anal. Biochem. 319, 335-336 (Pubitemid 36842747)
14. Beebe, K., Waas, W., Druzina, Z., Guo, M., and Schimmel, P. (2007) A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities. Anal. Biochem. 368, 111-121 (Pubitemid 47058432)
15. Goldfarb, D. S., Corbett, A. H., Mason, D. A., Harreman, M. T., and Adam, S. A. (2004) Importin α: a multipurpose nuclear-transport receptor. Trends Cell Biol. 14, 505-514
16. Yang, X. L., Skene, R. J., McRee, D. E., and Schimmel, P. (2002) Crystal structure of a human aminoacyl-tRNA synthetase cytokine. Proc. Natl. Acad. Sci. U.S.A. 99, 15369-15374 (Pubitemid 35403941)
17. Yang, X. L., Liu, F. M., Skene, R. J., McRee, D. E., and Schimmel, P. (2003) Crystal structure of an EMAP-II-like cytokine released from a human tRNA synthetase. Helvetica Chimica Acta 86, 1246-1257 (Pubitemid 36644476)
18. Tsunoda, M., Kusakabe, Y., Tanaka, N., Ohno, S., Nakamura, M., Senda, T., Moriguchi, T., Asai, N., Sekine, M., Yokogawa, T., Nishikawa, K., and Nakamura, K. T. (2007) Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms. Nucleic Acids Res. 35, 4289-4300 (Pubitemid 47244583)
19. Kobayashi, T., Nureki, O., Ishitani, R., Yaremchuk, A., Tukalo, M., Cusack, S., Sakamoto, K., and Yokoyama, S. (2003) Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion. Nat. Struct. Biol. 10, 425-432 (Pubitemid 36637639)
20. Yaremchuk, A., Kriklivyi, I., Tukalo, M., and Cusack, S. (2002) Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition. EMBO J. 21, 3829-3840 (Pubitemid 34787055)
21. Hopper, A. K., and Shaheen, H. H. (2008) A decade of surprises for tRNA nuclear-cytoplasmic dynamics. Trends Cell Biol. 18, 98-104
22. DeLano, W. L. (2010) The PyMOL Molecular Graphics System, version 0.99rc6, Schrödinger, LLC, New York