Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 5, 2010, Pages 2201-2206

  Hegan, Denise Campisi ^a   Lu, Yuhong ^a   Stacheleka, Gregory C ^a   Crosbya, Meredith E ^a   Bindraa, Ranjit S ^a   Glazer, Peter M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA repair; Hypoxia

Indexed keywords

3 AMINOBENZAMIDE; 4 AMINO 1,8 NAPHTHALIMIDE; 6 (5H) PHENANTHRIDINONE; ANI; BENZAMIDE; BRCA1 PROTEIN; KU 0058684; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN E7; PROTEIN P130; RAD51 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F4; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DOWN REGULATION; EXCISION REPAIR; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; RADIOSENSITIVITY; SEQUENCE HOMOLOGY;

CELL LINE, TUMOR; COLONIC NEOPLASMS; CRK-ASSOCIATED SUBSTRATE PROTEIN; DNA REPAIR; DOWN-REGULATION; E2F4 TRANSCRIPTION FACTOR; ENZYME INHIBITORS; GENES, BRCA1; HUMANS; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASES; PROMOTER REGIONS, GENETIC; RAD51 RECOMBINASE; RADIATION-SENSITIZING AGENTS; RNA, SMALL INTERFERING;

HUMAN PAPILLOMAVIRUS;

EID: 76649094290     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904783107     Document Type: Article

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