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The latent reservoir for HIV-1 in resting CD4+ T cells: a barrier to cure
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Siliciano JD, Siliciano RF. The latent reservoir for HIV-1 in resting CD4+ T cells: a barrier to cure. Curr Opin HIV AIDS. 2006;1:121–8.
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Developing strategies for HIV-1 eradication
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COI: 1:CAS:528:DC%2BC38XhtFGitrrE, PID: 22867874, Excellent review and overview of the obsacle of the HIV reservoir and the strategies to eliminate it
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Durand CM, Blankson JN, Siliciano RF. Developing strategies for HIV-1 eradication. Trends Immunol. 2012;33:554–62. Excellent review and overview of the obsacle of the HIV reservoir and the strategies to eliminate it.
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Trends Immunol
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Durand, C.M.1
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Immunologic strategies for HIV-1 remission and eradication
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COI: 1:CAS:528:DC%2BC2cXhtFWjtLnF, PID: 25013067
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Barouch DH, Deeks SG. Immunologic strategies for HIV-1 remission and eradication. Science. 2014;345:169–74.
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Barouch, D.H.1
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Prospects for treatment of latent HIV
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COI: 1:CAS:528:DC%2BC38XhvVGms7rP, PID: 23212106
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Barton KM, Burch BD, Soriano-Sarabia N, Margolis DM. Prospects for treatment of latent HIV. Clin Pharmacol Ther. 2013;93:46–56.
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Clin Pharmacol Ther
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A roadmap toward clinical translation of genetically-modified stem cells for treatment of HIV
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COI: 1:CAS:528:DC%2BC2cXhsV2ktrvP, PID: 25262540
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Abou-El-Enein M, Bauer G, Reinke P, Renner M, Schneider CK. A roadmap toward clinical translation of genetically-modified stem cells for treatment of HIV. Trends Mol Med. 2014;20(11):632–42.
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The search for an HIV cure: tackling latent infection
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Kent SJ, Reece JC, Petravic J, Martyushev A, Kramski M, De Rose R, et al. The search for an HIV cure: tackling latent infection. Lancet Infect Dis. 2013;13:614–21.
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De Rose, R.6
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7
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Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs
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COI: 1:CAS:528:DC%2BD1MXht1Kqsb7J, PID: 19834480
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Coiras M, Lopez-Huertas MR, Perez-Olmeda M, Alcami J. Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs. Nat Rev Microbiol. 2009;7:798–812.
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Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature. 2014;512:74–7. This study shows that upon viral infection the viral reservoir is established very early (in less than three days) in an animal model. This study also shows that HIV is detectable in lymph nodes but not in blood of some animals, suggesting that lymph nodes may be an early and important reservoir
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Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature. 2014;512:74–7. This study shows that upon viral infection the viral reservoir is established very early (in less than three days) in an animal model. This study also shows that HIV is detectable in lymph nodes but not in blood of some animals, suggesting that lymph nodes may be an early and important reservoir.
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9
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84897440149
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COI: 1:CAS:528:DC%2BC2cXksVWgsbg%3D, PID: 24641995
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Zaikos TD, Collins KL. Long-lived reservoirs of HIV-1. Trends Microbiol. 2014;22:173–5.
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Zaikos, T.D.1
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Redefining the viral reservoirs that prevent HIV-1 eradication
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COI: 1:CAS:528:DC%2BC38XhtlyltLvN, PID: 22999944
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Eisele E, Siliciano RF. Redefining the viral reservoirs that prevent HIV-1 eradication. Immunity. 2012;37:377–88.
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Coleman CM, Wu L. HIV interactions with monocytes and dendritic cells: viral latency and reservoirs. Retrovirology. 2009;6:51.
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Coleman, C.M.1
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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
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COI: 1:CAS:528:DC%2BC2cXisFOksb4%3D, PID: 24469825
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Fletcher CV, Staskus K, Wietgrefe SW, Rothenberger M, Reilly C, Chipman JG, et al. Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc Natl Acad Sci U S A. 2014;111:2307–12.
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Chipman, J.G.6
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13
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Costiniuk, C.T.1
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14
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Is the central nervous system a reservoir of HIV-1?
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COI: 1:CAS:528:DC%2BC2cXhs12rsrzN, PID: 25203642
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Gray LR, Roche M, Flynn JK, Wesselingh SL, Gorry PR, Churchill MJ. Is the central nervous system a reservoir of HIV-1? Curr Opin HIV AIDS. 2014;9:552–8.
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Gray, L.R.1
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Churchill, M.J.6
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15
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PID: 24415939
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Denton PW, Long JM, Wietgrefe SW, Sykes C, Spagnuolo RA, Snyder OD, et al. Targeted cytotoxic therapy kills persisting HIV infected cells during ART. PLoS Pathog. 2014;10:e1003872.
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Denton, P.W.1
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Snyder, O.D.6
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16
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The quantitation of replication-competent HIV-1 in populations of resting CD4+ T cells
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Soriano-Sarabia N, Bateson RE, Dahl NP, Crooks AM, Kuruc JD, Margolis DM, et al. The quantitation of replication-competent HIV-1 in populations of resting CD4+ T cells. J Virol. 2014; 88:14070-7.
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Soriano-Sarabia, N.1
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Margolis, D.M.6
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17
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84899154430
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HIV-1 latency in monocytes/macrophages
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COI: 1:CAS:528:DC%2BC2cXhs1CqsbnP, PID: 24759213
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Kumar A, Abbas W, Herbein G. HIV-1 latency in monocytes/macrophages. Viruses. 2014;6:1837–60.
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Kumar, A.1
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18
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A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection
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COI: 1:CAS:528:DC%2BC3sXot1yntb8%3D, PID: 23691172
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Bacchus C, Cheret A, Avettand-Fenoel V, Nembot G, Melard A, Blanc C, et al. A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection. PLoS ONE. 2013;8:e64219.
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Bacchus, C.1
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19
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PID: 24620025
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Archin NM, Bateson R, Tripathy MK, Crooks AM, Yang KH, Dahl NP, et al. HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat. J Infect Dis. 2014;210:728–35.
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Dahl, N.P.6
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20
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84887319972
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HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice
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COI: 1:CAS:528:DC%2BC3sXhsF2rtbrJ, PID: 23886835
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Nixon CC, Vatakis DN, Reichelderfer SN, Dixit D, Kim SG, Uittenbogaart CH, et al. HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice. Blood. 2013;122:2195–204.
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Uittenbogaart, C.H.6
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21
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84877954030
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CD133+ hematopoietic progenitor cells harbor HIV genomes in a subset of optimally treated people with long-term viral suppression
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PID: 23554378
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McNamara LA, Onafuwa-Nuga A, Sebastian NT, Riddell J, Bixby D, Collins KL. CD133+ hematopoietic progenitor cells harbor HIV genomes in a subset of optimally treated people with long-term viral suppression. J Infect Dis. 2013;207:1807–16.
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Narasipura SD, Kim S, Al-Harthi L. Epigenetic regulation of HIV-1 latency in astrocytes. J Virol. 2014;88:3031–8.
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23
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Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy
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COI: 1:CAS:528:DC%2BC2cXltl2hurs%3D, PID: 24706775, This study measured the fraction of the inducible reservoir upon exposure to different conditions
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Cillo AR, Sobolewski MD, Bosch RJ, Fyne E, Piatak Jr M, Coffin JM, et al. Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy. Proc Natl Acad Sci U S A. 2014;111:7078–83. This study measured the fraction of the inducible reservoir upon exposure to different conditions.
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Proc Natl Acad Sci U S A
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Cillo, A.R.1
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Coffin, J.M.6
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24
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HIV reservoirs and latency models
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Pace MJ, Agosto L, Graf EH, O’Doherty U. HIV reservoirs and latency models. Virology. 2011;411:344–54.
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25
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84859373016
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HIV latency: experimental systems and molecular models
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COI: 1:CAS:528:DC%2BC38Xmtlygsbo%3D, PID: 22372374
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Hakre S, Chavez L, Shirakawa K, Verdin E. HIV latency: experimental systems and molecular models. FEMS Microbiol Rev. 2012;36:706–16.
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26
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An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients
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PID: 24385908, A comparative study of different HIV latency cell models and their response to multiple latency reactivating agents or stimuli
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Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, et al. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog. 2013;9:e1003834. A comparative study of different HIV latency cell models and their response to multiple latency reactivating agents or stimuli.
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27
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84878459431
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Reactivation of latent HIV by histone deacetylase inhibitors
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COI: 1:CAS:528:DC%2BC3sXktlSjtbk%3D, PID: 23517573
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Shirakawa K, Chavez L, Hakre S, Calvanese V, Verdin E. Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol. 2013;21:277–85.
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28
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Emerging strategies to deplete the HIV reservoir
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Archin NM, Margolis DM. Emerging strategies to deplete the HIV reservoir. Curr Opin Infect Dis. 2014;27:29–35.
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Targeting HIV latency: pharmacologic strategies toward eradication
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Xing S, Siliciano RF. Targeting HIV latency: pharmacologic strategies toward eradication. Drug Discov Today. 2013;18:541–51.
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COI: 1:CAS:528:DC%2BC3sXktlWjtrY%3D, PID: 23459007, A comparative study of different methods to estimate the size of the viral reservoir
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Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, et al. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog. 2013;9:e1003174. A comparative study of different methods to estimate the size of the viral reservoir.
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31
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COI: 1:CAS:528:DC%2BC3sXhs1yrurrI, PID: 24243014, This study quantified the proportion of HIV+ cells carrying defective versus replication-competent proviral sequences
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Ho YC, Shan L, Hosmane NN, Wang J, Laskey SB, Rosenbloom DI, et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell. 2013;155:540–51. This study quantified the proportion of HIV+ cells carrying defective versus replication-competent proviral sequences.
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Cell
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Dynamics of HIV latency and reactivation in a primary CD4+ T cell model
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PID: 24875931, This study characterized the joint viral and cellular transcriptome in a latency model over time. Post-transcriptional block and cellular activation status were identified as components of latency
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Mohammadi P, di Iulio J, Munoz M, Martinez R, Bartha I, Cavassini M, et al. Dynamics of HIV latency and reactivation in a primary CD4+ T cell model. PLoS Pathog. 2014;10:e1004156. This study characterized the joint viral and cellular transcriptome in a latency model over time. Post-transcriptional block and cellular activation status were identified as components of latency.
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Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy
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Papayannakos C, Daniel R. Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy. Gene Ther. 2013;20:581–8.
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