HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice

Blood

Volumn 122, Issue 13, 2013, Pages 2195-2204

  Nixon, Christopher C ^a   Vatakis, Dimitrios N ^a,b   Reichelderfer, Scott N ^a,c   Dixit, Dhaval ^a   Kim, Sohn G ^a,b   Uittenbogaart, Christel H ^a,b   Zack, Jerome A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD123 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; THROMBOPOIETIN RECEPTOR; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL POPULATION; CONTROLLED STUDY; CYTOTOXICITY; DNA VIRUS; FLOW CYTOMETRY; GRANULOCYTE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; IN VIVO STUDY; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; ANIMAL; DISEASE MODEL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; VIROLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; DNA, VIRAL; FLOW CYTOMETRY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HIV INFECTIONS; HIV-1; HUMANS; MICE; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84887319972     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-04-496950     Document Type: Article

References (39)

1. Rosenfeld SJ, Young NS. Viruses and bone marrow failure. Blood Rev. 1991;5(2):71-77.
2. Marche C, Tabbara W, Michon C, Clair B, Bricaire F, Matthiessen L. Bone marrow findings in HIV infection: a pathological study. Prog AIDS Pathol. 1990;2:51-60.
3. Donahue RE, Johnson MM, Zon LI, Clark SC, Groopman JE. Suppression of in vitro haematopoiesis following human immunodeficiency virus infection. Nature. 1987;326(6109):200-203.
4. Treacy M, Lai L, Costello C, Clark A. Peripheral blood and bone marrow abnormalities in patients with HIV related disease. Br J Haematol. 1987; 65(3):289-294.
5. Scaradavou A. HIV-related thrombocytopenia. Blood Rev. 2002;16(1):73-76.
6. Costantini A, Giuliodoro S, Butini L, Silvestri G, Leoni P, Montroni M. Abnormalities of erythropoiesis during HIV-1 disease: a longitudinal analysis. J Acquir Immune Defic Syndr. 2009;52(1): 70-74.
7. Koka PS, Fraser JK, Bryson Y, et al. Human immunodeficiency virus inhibits multilineage hematopoiesis in vivo. J Virol. 1998;72(6): 5121-5127.
8. Jenkins M, Hanley MB, Moreno MB, Wieder E, McCune JM. Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo. Blood. 1998;91(8): 2672-2678.
9. Sloand E. Hematologic complications of HIV infection. AIDS Rev. 2005;7(4):187-196.
10. Moses A, Nelson J, Bagby GC Jr. The influence of human immunodeficiency virus-1 on hematopoiesis. Blood. 1998;91(5):1479-1495.
11. Isgrò A, Mezzaroma I, Aiuti A, et al. Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy. AIDS. 2004;18(9): 1335-1337.
12. Huang SS, Barbour JD, Deeks SG, et al. Reversal of human immunodeficiency virus type 1-associated hematosuppression by effective antiretroviral therapy. Clin Infect Dis. 2000;30(3): 504-510.
13. Deeks SG, McCune JM. Can HIV be cured with stem cell therapy? Nat Biotechnol. 2010;28(8): 807-810.
14. Kawamoto H, Ikawa T, Masuda K, Wada H, Katsura Y. A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model. Immunol Rev. 2010; 238(1):23-36.
15. Scadden DT, Zeira M, Woon A, et al. Human immunodeficiency virus infection of human bone marrow stromal fibroblasts. Blood. 1990;76(2): 317-322.
16. Alexaki A, Wigdahl B. HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination. PLoS Pathog. 2008;4(12):e1000215.
17. Carter CC, Onafuwa-Nuga A, McNamara LA, et al. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nat Med. 2010;16(4):446-451.
18. Carter CC, McNamara LA, Onafuwa-Nuga A, et al. HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe. 2011; 9(3):223-234.
19. Durand CM, Ghiaur G, Siliciano JD, et al. HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy. J Infect Dis. 2012;205(6):1014-1018.
20. Josefsson L, Eriksson S, Sinclair E, et al. Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA. J Infect Dis. 2012;206(1): 28-34.
21. McNamara LA, Onafuwa-Nuga A, Sebastian NT, et al. CD133+ HPCs harbor HIV genomes in a subset of optimally treated people with long-term viral suppression. J Infect Dis. 2013;207(12): 1807-1816.
22. Novershtern N, Subramanian A, Lawton LN, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011;144(2):296-309.
23. Mercer EM, Lin YC, Murre C. Factors and networks that underpin early hematopoiesis. Semin Immunol. 2011;23(5):317-325.
24. Banda NK, Simon GR, Sipple JD, et al. Depletion of CD34+ CD4+ cells in bone marrow from HIV-1-infected individuals. Biol Blood Marrow Transplant. 1999;5(3):162-172.
25. Deichmann M, Kronenwett R, Haas R. Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD341 hematopoietic progenitor cells. Blood. 1997;89(10):3522-3528.
26. Ruiz ME, Cicala C, Arthos J, et al. Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV. J Immunol. 1998;161(8):4169-4176.
27. Shen H, Cheng T, Preffer FI, et al. Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression. J Virol. 1999;73(1):728-737.
28. Sasaki Y, Matsuoka Y, Hase M, et al. Marginal expression of CXCR4 on c-kit(+)Sca-1 (+) Lineage (-) hematopoietic stem/progenitor cells. Int J Hematol. 2009;90(5):553-560.
29. Isgro A, Mezzaroma A, Aiuti A, et al. Recovery of hematopoietic activity in bone marrow from human immunodeficiency type 1-infected patients during highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2000;15(16): 1471-1479.
30. Isgrò A, Aiuti A, Leti W, et al. Immunodysregulation of HIV disease at bone marrow level. Autoimmun Rev. 2005;4(8): 486-490.
31. Jamieson BD, Zack JA. In vivo pathogenesis of a human immunodeficiency virus type 1 reporter virus. J Virol. 1998;72(8):6520-6526.
32. Vatakis DN, Nixon CC, Bristol G, Zack JA. Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents. J Virol. 2009;83(7):3374- 3378.
33. Vatakis DN, Kim S, Kim N, Chow SA, Zack JA. Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells. J Virol. 2009;83(12): 6222-6233.
34. Kitchen SG, Levin BR, Bristol G, et al. In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells. PLoS Pathog. 2012;8(4):e1002649.
35. Edvardsson L, Dykes J, Olofsson T. Isolation and characterization of human myeloid progenitor populations-TpoR as discriminator between common myeloid and megakaryocyte/ erythroid progenitors. Exp Hematol. 2006;34(5): 599-609.
36. Xiao P, Usami O, Suzuki Y, et al. Characterization of a CD4-independent clinical HIV-1 that can efficiently infect human hepatocytes through chemokine (C-X-C motif) receptor 4. AIDS. 2008; 22(14):1749-1757.
37. Koka PS, Jamieson BD, Brooks DG, Zack JA. Human immunodeficiency virus type 1-induced hematopoietic inhibition is independent of productive infection of progenitor cells in vivo. J Virol. 1999;73(11):9089-9097.
38. McNamara LA, Ganesh JA, Collins KL. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation. J Virol. 2012;86(17): 9337-9350.
39. Benveniste P, Frelin C, Janmohamed S, et al. Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. Cell Stem Cell. 2010;6(1):48-58.