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Volumn 8, Issue 7, 2012, Pages 15-

Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; VIRUS DNA; CD28 ANTIGEN; CD3 ANTIGEN; INTERLEUKIN 17; MACROPHAGE INFLAMMATORY PROTEIN; VIRUS ENVELOPE PROTEIN;

EID: 84864625807     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002818     Document Type: Article
Times cited : (126)

References (64)
  • 1
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun TW, Carruth L, Finzi D, Shen X, DiGiuseppe JA, et al. (1997) Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387: 183-188.
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1    Carruth, L.2    Finzi, D.3    Shen, X.4    DiGiuseppe, J.A.5
  • 2
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, et al. (1999) Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 5: 512-517.
    • (1999) Nat Med , vol.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.D.3    Margolick, J.B.4    Chadwick, K.5
  • 3
    • 84856190985 scopus 로고    scopus 로고
    • A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs
    • Lassen KG, Hebbeler AM, Bhattacharyya D, Lobritz MA, Greene WC, (2012) A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs. PLoS One 7: e30176.
    • (2012) PLoS One , vol.7
    • Lassen, K.G.1    Hebbeler, A.M.2    Bhattacharyya, D.3    Lobritz, M.A.4    Greene, W.C.5
  • 5
    • 0036315848 scopus 로고    scopus 로고
    • Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    • Korin YD, Brooks DG, Brown S, Korotzer A, Zack JA, (2002) Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J Virol 76: 8118-8123.
    • (2002) J Virol , vol.76 , pp. 8118-8123
    • Korin, Y.D.1    Brooks, D.G.2    Brown, S.3    Korotzer, A.4    Zack, J.A.5
  • 6
    • 27644599799 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli
    • Swiggard WJ, Baytop C, Yu JJ, Dai J, Li C, et al. (2005) Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli. J Virol 79: 14179-14188.
    • (2005) J Virol , vol.79 , pp. 14179-14188
    • Swiggard, W.J.1    Baytop, C.2    Yu, J.J.3    Dai, J.4    Li, C.5
  • 7
    • 71849085382 scopus 로고    scopus 로고
    • An in vitro system to model the establishment and reactivation of HIV-1 latency
    • Marini A, Harper JM, Romerio F, (2008) An in vitro system to model the establishment and reactivation of HIV-1 latency. J Immunol 181: 7713-7720.
    • (2008) J Immunol , vol.181 , pp. 7713-7720
    • Marini, A.1    Harper, J.M.2    Romerio, F.3
  • 8
    • 59449101108 scopus 로고    scopus 로고
    • Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
    • Bosque A, Planelles V, (2009) Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells. Blood 113: 58-65.
    • (2009) Blood , vol.113 , pp. 58-65
    • Bosque, A.1    Planelles, V.2
  • 9
    • 70449377960 scopus 로고    scopus 로고
    • Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation
    • Yang HC, Xing S, Shan L, O'Connell K, Dinoso J, et al. (2009) Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. J Clin Invest 119: 3473-3486.
    • (2009) J Clin Invest , vol.119 , pp. 3473-3486
    • Yang, H.C.1    Xing, S.2    Shan, L.3    O'Connell, K.4    Dinoso, J.5
  • 10
    • 77958485320 scopus 로고    scopus 로고
    • Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton
    • Cameron PU, Saleh S, Sallmann G, Solomon A, Wightman F, et al. (2011) Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton. Proc Natl Acad Sci U S A 107: 16934-16939.
    • (2011) Proc Natl Acad Sci U S A , vol.107 , pp. 16934-16939
    • Cameron, P.U.1    Saleh, S.2    Sallmann, G.3    Solomon, A.4    Wightman, F.5
  • 11
    • 39649100240 scopus 로고    scopus 로고
    • CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency
    • Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron PU, et al. (2007) CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency. Blood 110: 4161-4164.
    • (2007) Blood , vol.110 , pp. 4161-4164
    • Saleh, S.1    Solomon, A.2    Wightman, F.3    Xhilaga, M.4    Cameron, P.U.5
  • 12
    • 34447262581 scopus 로고    scopus 로고
    • A Primary Cell Model For Activation Inducible Human Immunodeficiency Virus
    • Burke B, Brown HJ, Marsden MD, Bristol G, Vatakis DN, et al. (2007) A Primary Cell Model For Activation Inducible Human Immunodeficiency Virus. J Virol 81: 7424-34.
    • (2007) J Virol , vol.81 , pp. 7424-7434
    • Burke, B.1    Brown, H.J.2    Marsden, M.D.3    Bristol, G.4    Vatakis, D.N.5
  • 13
    • 77953313393 scopus 로고    scopus 로고
    • Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction
    • Tyagi M, Pearson RJ, Karn J, (2010) Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction. J Virol 84: 6425-6437.
    • (2010) J Virol , vol.84 , pp. 6425-6437
    • Tyagi, M.1    Pearson, R.J.2    Karn, J.3
  • 14
    • 0026526144 scopus 로고
    • Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle
    • Zack JA, Haislip AM, Krogstad P, Chen ISY, (1992) Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle. J Virol 66: 1717-1725.
    • (1992) J Virol , vol.66 , pp. 1717-1725
    • Zack, J.A.1    Haislip, A.M.2    Krogstad, P.3    Chen, I.S.Y.4
  • 15
    • 78549272646 scopus 로고    scopus 로고
    • Quiescent T cells and HIV: an unresolved relationship
    • Vatakis DN, Nixon CC, Zack JA, (2010) Quiescent T cells and HIV: an unresolved relationship. Immunol Res 48: 110-121.
    • (2010) Immunol Res , vol.48 , pp. 110-121
    • Vatakis, D.N.1    Nixon, C.C.2    Zack, J.A.3
  • 16
    • 33947403942 scopus 로고    scopus 로고
    • Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells
    • Vatakis DN, Bristol G, Wilkinson TA, Chow SA, Zack JA, (2007) Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells. J Virol 81: 3574-3582.
    • (2007) J Virol , vol.81 , pp. 3574-3582
    • Vatakis, D.N.1    Bristol, G.2    Wilkinson, T.A.3    Chow, S.A.4    Zack, J.A.5
  • 17
    • 0033532628 scopus 로고    scopus 로고
    • Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes
    • Unutmaz D, KewalRamani VN, Marmon S, Littman DR, (1999) Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. Exp Med 189: 1735-1746.
    • (1999) Exp Med , vol.189 , pp. 1735-1746
    • Unutmaz, D.1    KewalRamani, V.N.2    Marmon, S.3    Littman, D.R.4
  • 18
    • 0242364699 scopus 로고    scopus 로고
    • Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents
    • Kinter A, Moorthy A, Jackson R, Fauci AS, (2003) Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents. AIDS Res Hum Retroviruses 19: 847-856.
    • (2003) AIDS Res Hum Retroviruses , vol.19 , pp. 847-856
    • Kinter, A.1    Moorthy, A.2    Jackson, R.3    Fauci, A.S.4
  • 20
    • 0037441766 scopus 로고    scopus 로고
    • Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation
    • Marktel S, Magnani Z, Ciceri F, Cazzaniga S, Riddell SR, et al. (2003) Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation. Blood 101: 1290-1298.
    • (2003) Blood , vol.101 , pp. 1290-1298
    • Marktel, S.1    Magnani, Z.2    Ciceri, F.3    Cazzaniga, S.4    Riddell, S.R.5
  • 21
    • 34249868241 scopus 로고    scopus 로고
    • Adoptive T cell therapy for cancer in the clinic
    • June CH, (2007) Adoptive T cell therapy for cancer in the clinic. J Clin Invest 117: 1466-1476.
    • (2007) J Clin Invest , vol.117 , pp. 1466-1476
    • June, C.H.1
  • 22
    • 80053913294 scopus 로고    scopus 로고
    • Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells
    • Saleh S, Wightman F, Ramanayake S, Alexander M, Kumar N, et al. (2011) Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells. Retrovirology 8: 80.
    • (2011) Retrovirology , vol.8 , pp. 80
    • Saleh, S.1    Wightman, F.2    Ramanayake, S.3    Alexander, M.4    Kumar, N.5
  • 23
    • 66149118152 scopus 로고    scopus 로고
    • Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells
    • Dai J, Agosto LM, Baytop C, Yu JJ, Pace MJ, et al. (2009) Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells. J Virol 83: 4528-4537.
    • (2009) J Virol , vol.83 , pp. 4528-4537
    • Dai, J.1    Agosto, L.M.2    Baytop, C.3    Yu, J.J.4    Pace, M.J.5
  • 24
    • 35348929372 scopus 로고    scopus 로고
    • HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration
    • Agosto LM, Yu JJ, Dai J, Kaletsky R, Monie D, et al. (2007) HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration. Virology 368: 60-72.
    • (2007) Virology , vol.368 , pp. 60-72
    • Agosto, L.M.1    Yu, J.J.2    Dai, J.3    Kaletsky, R.4    Monie, D.5
  • 25
    • 0032742547 scopus 로고    scopus 로고
    • Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells
    • Zhang Z-Q, Schuler T, Zupancic M, Wietgrefe S, Staskus KA, et al. (1999) Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 286: 1353-1357.
    • (1999) Science , vol.286 , pp. 1353-1357
    • Zhang, Z.-Q.1    Schuler, T.2    Zupancic, M.3    Wietgrefe, S.4    Staskus, K.A.5
  • 26
    • 1842782773 scopus 로고    scopus 로고
    • Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection
    • Zhang ZQ, Wietgrefe SW, Li Q, Shore MD, Duan L, et al. (2004) Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection. Proc Natl Acad Sci U S A 101: 5640-5645.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 5640-5645
    • Zhang, Z.Q.1    Wietgrefe, S.W.2    Li, Q.3    Shore, M.D.4    Duan, L.5
  • 27
    • 80053959566 scopus 로고    scopus 로고
    • Spinoculation triggers dynamic actin and cofilin activity that facilitates HIV-1 infection of transformed and resting CD4 T cells
    • Guo J, Wang W, Yu D, Wu Y, (2011) Spinoculation triggers dynamic actin and cofilin activity that facilitates HIV-1 infection of transformed and resting CD4 T cells. J Virol 85: 9824-9833.
    • (2011) J Virol , vol.85 , pp. 9824-9833
    • Guo, J.1    Wang, W.2    Yu, D.3    Wu, Y.4
  • 28
    • 67749131112 scopus 로고    scopus 로고
    • The CXCR4-tropic human immunodeficiency virus envelope promotes more-efficient gene delivery to resting CD4+ T cells than the vesicular stomatitis virus glycoprotein G envelope
    • Agosto LM, Yu JJ, Liszewski MK, Baytop C, Korokhov N, et al. (2009) The CXCR4-tropic human immunodeficiency virus envelope promotes more-efficient gene delivery to resting CD4+ T cells than the vesicular stomatitis virus glycoprotein G envelope. J Virol 83: 8153-8162.
    • (2009) J Virol , vol.83 , pp. 8153-8162
    • Agosto, L.M.1    Yu, J.J.2    Liszewski, M.K.3    Baytop, C.4    Korokhov, N.5
  • 29
    • 37049009746 scopus 로고    scopus 로고
    • Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells
    • Plesa G, Dai J, Baytop C, Riley JL, June CH, et al. (2007) Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells. J Virol 81: 13938-13942.
    • (2007) J Virol , vol.81 , pp. 13938-13942
    • Plesa, G.1    Dai, J.2    Baytop, C.3    Riley, J.L.4    June, C.H.5
  • 30
    • 34548014737 scopus 로고    scopus 로고
    • Revving the engine: signal transduction fuels T cell activation
    • Jones RG, Thompson CB, (2007) Revving the engine: signal transduction fuels T cell activation. Immunity 27: 173-178.
    • (2007) Immunity , vol.27 , pp. 173-178
    • Jones, R.G.1    Thompson, C.B.2
  • 31
    • 17944375042 scopus 로고    scopus 로고
    • HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues
    • Eckstein DA, Penn ML, Korin YD, Scripture-Adams DD, Zack JA, et al. (2001) HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues. Immunity 15: 671-682.
    • (2001) Immunity , vol.15 , pp. 671-682
    • Eckstein, D.A.1    Penn, M.L.2    Korin, Y.D.3    Scripture-Adams, D.D.4    Zack, J.A.5
  • 32
  • 33
    • 21044451712 scopus 로고    scopus 로고
    • Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription
    • Lewinski MK, Bisgrove D, Shinn P, Chen H, Hoffmann C, et al. (2005) Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J Virol 79: 6610-6619.
    • (2005) J Virol , vol.79 , pp. 6610-6619
    • Lewinski, M.K.1    Bisgrove, D.2    Shinn, P.3    Chen, H.4    Hoffmann, C.5
  • 34
    • 0037446948 scopus 로고    scopus 로고
    • HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
    • Jordan A, Bisgrove D, Verdin E, (2003) HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. Embo J 22: 1868-1877.
    • (2003) Embo J , vol.22 , pp. 1868-1877
    • Jordan, A.1    Bisgrove, D.2    Verdin, E.3
  • 35
    • 68649099762 scopus 로고    scopus 로고
    • HIV integration site distributions in resting and activated CD4+ T cells infected in culture
    • Brady T, Agosto LM, Malani N, Berry CC, O'Doherty U, et al. (2009) HIV integration site distributions in resting and activated CD4+ T cells infected in culture. AIDS 23: 1461-1471.
    • (2009) AIDS , vol.23 , pp. 1461-1471
    • Brady, T.1    Agosto, L.M.2    Malani, N.3    Berry, C.C.4    O'Doherty, U.5
  • 36
    • 73249136755 scopus 로고    scopus 로고
    • Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies
    • Colin L, Van Lint C, (2009) Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. Retrovirology 6: 111.
    • (2009) Retrovirology , vol.6 , pp. 111
    • Colin, L.1    van Lint, C.2
  • 37
    • 79957888573 scopus 로고    scopus 로고
    • Mechanisms of HIV-associated lymphocyte apoptosis: 2010
    • Cummins NW, Badley AD, (2010) Mechanisms of HIV-associated lymphocyte apoptosis: 2010. Cell Death Dis 1: e99.
    • (2010) Cell Death Dis , vol.1
    • Cummins, N.W.1    Badley, A.D.2
  • 38
    • 0038725688 scopus 로고    scopus 로고
    • Apoptosis as an HIV strategy to escape immune attack
    • Gougeon ML, (2003) Apoptosis as an HIV strategy to escape immune attack. Nat Rev Immunol 3: 392-404.
    • (2003) Nat Rev Immunol , vol.3 , pp. 392-404
    • Gougeon, M.L.1
  • 39
    • 0028850465 scopus 로고
    • Human naive and memory T lymphocytes differ in telomeric length and replicative potential
    • Weng NP, Levine BL, June CH, Hodes RJ, (1995) Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc Natl Acad Sci U S A 92: 11091-11094.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11091-11094
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 40
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, et al. (2012) Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36: 491-501.
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1    Deng, K.2    Shroff, N.S.3    Durand, C.M.4    Rabi, S.A.5
  • 42
    • 0034979270 scopus 로고    scopus 로고
    • Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy
    • Casazza JP, Betts MR, Picker LJ, Koup RA, (2001) Decay kinetics of human immunodeficiency virus-specific CD8+ T cells in peripheral blood after initiation of highly active antiretroviral therapy. J Virol 75: 6508-6516.
    • (2001) J Virol , vol.75 , pp. 6508-6516
    • Casazza, J.P.1    Betts, M.R.2    Picker, L.J.3    Koup, R.A.4
  • 43
    • 0032789091 scopus 로고    scopus 로고
    • Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy
    • Kalams SA, Goulder PJ, Shea AK, Jones NG, Trocha AK, et al. (1999) Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy. J Virol 73: 6721-6728.
    • (1999) J Virol , vol.73 , pp. 6721-6728
    • Kalams, S.A.1    Goulder, P.J.2    Shea, A.K.3    Jones, N.G.4    Trocha, A.K.5
  • 44
    • 4143061435 scopus 로고    scopus 로고
    • Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivo
    • Lassen KG, Bailey JR, Siliciano RF, (2004) Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivo. J Virol 78: 9105-9114.
    • (2004) J Virol , vol.78 , pp. 9105-9114
    • Lassen, K.G.1    Bailey, J.R.2    Siliciano, R.F.3
  • 45
    • 68649095173 scopus 로고    scopus 로고
    • Chapter 1. Regulation of HIV-1 alternative RNA splicing and its role in virus replication
    • Stoltzfus CM, (2009) Chapter 1. Regulation of HIV-1 alternative RNA splicing and its role in virus replication. Adv Virus Res 74: 1-40.
    • (2009) Adv Virus Res , vol.74 , pp. 1-40
    • Stoltzfus, C.M.1
  • 46
    • 77249123298 scopus 로고    scopus 로고
    • Mechanisms of HIV latency: an emerging picture of complexity
    • Margolis DM, (2010) Mechanisms of HIV latency: an emerging picture of complexity. Curr HIV/AIDS Rep 7: 37-43.
    • (2010) Curr HIV/AIDS Rep , vol.7 , pp. 37-43
    • Margolis, D.M.1
  • 47
    • 69049088648 scopus 로고    scopus 로고
    • T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma
    • Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, et al. (2009) T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol 10: 992-999.
    • (2009) Nat Immunol , vol.10 , pp. 992-999
    • Yu, Q.1    Sharma, A.2    Oh, S.Y.3    Moon, H.G.4    Hossain, M.Z.5
  • 48
    • 0025155252 scopus 로고
    • Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner
    • Waterman ML, Jones KA, (1990) Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner. New Biol 2: 621-636.
    • (1990) New Biol , vol.2 , pp. 621-636
    • Waterman, M.L.1    Jones, K.A.2
  • 49
    • 48649085472 scopus 로고    scopus 로고
    • Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough
    • Han Y, Lin YB, An W, Xu J, Yang HC, et al. (2008) Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe 4: 134-146.
    • (2008) Cell Host Microbe , vol.4 , pp. 134-146
    • Han, Y.1    Lin, Y.B.2    An, W.3    Xu, J.4    Yang, H.C.5
  • 50
    • 59649119778 scopus 로고    scopus 로고
    • Cessation of HIV-1 transcription by inhibiting regulatory protein Rev-mediated RNA transport
    • Cao Y, Liu X, De Clercq E, (2009) Cessation of HIV-1 transcription by inhibiting regulatory protein Rev-mediated RNA transport. Curr HIV Res 7: 101-108.
    • (2009) Curr HIV Res , vol.7 , pp. 101-108
    • Cao, Y.1    Liu, X.2    de Clercq, E.3
  • 51
    • 0038468339 scopus 로고    scopus 로고
    • Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo
    • Hermankova M, Siliciano JD, Zhou Y, Monie D, Chadwick K, et al. (2003) Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo. J Virol 77: 7383-7392.
    • (2003) J Virol , vol.77 , pp. 7383-7392
    • Hermankova, M.1    Siliciano, J.D.2    Zhou, Y.3    Monie, D.4    Chadwick, K.5
  • 52
    • 0036616965 scopus 로고    scopus 로고
    • Residual cell-associated unspliced HIV-1 RNA in peripheral blood of patients on potent antiretroviral therapy represents intracellular transcripts
    • Fischer M, Wong JK, Russenberger D, Joos B, Opravil M, et al. (2002) Residual cell-associated unspliced HIV-1 RNA in peripheral blood of patients on potent antiretroviral therapy represents intracellular transcripts. Antivir Ther 7: 91-103.
    • (2002) Antivir Ther , vol.7 , pp. 91-103
    • Fischer, M.1    Wong, J.K.2    Russenberger, D.3    Joos, B.4    Opravil, M.5
  • 53
    • 0033031005 scopus 로고    scopus 로고
    • Use of real-time PCR and molecular beacons to detect virus replication in Human Immunodeficiency Virus type 1-infected individuals on prolonged effective antiretroviral therapy
    • Lewin SR, Vesana M, Kostrikis L, (1999) Use of real-time PCR and molecular beacons to detect virus replication in Human Immunodeficiency Virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol 73: 6099-6103.
    • (1999) J Virol , vol.73 , pp. 6099-6103
    • Lewin, S.R.1    Vesana, M.2    Kostrikis, L.3
  • 54
    • 31144461409 scopus 로고    scopus 로고
    • Rapid expression of human immunodeficiency virus following activation of latently infected cells
    • Arlen PA, Brooks DG, Gao LY, Vatakis D, Brown HJ, et al. (2006) Rapid expression of human immunodeficiency virus following activation of latently infected cells. J Virol 80: 1599-1603.
    • (2006) J Virol , vol.80 , pp. 1599-1603
    • Arlen, P.A.1    Brooks, D.G.2    Gao, L.Y.3    Vatakis, D.4    Brown, H.J.5
  • 55
    • 0033780046 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding
    • O'Doherty U, Swiggard WJ, Malim MH, (2000) Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding. J Virol 74: 10074-10080.
    • (2000) J Virol , vol.74 , pp. 10074-10080
    • O'Doherty, U.1    Swiggard, W.J.2    Malim, M.H.3
  • 56
    • 77951877224 scopus 로고    scopus 로고
    • HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses
    • Owen RE, Heitman JW, Hirschkorn DF, Lanteri MC, Biswas HH, et al. (2010) HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses. AIDS 24: 1095-1105.
    • (2010) AIDS , vol.24 , pp. 1095-1105
    • Owen, R.E.1    Heitman, J.W.2    Hirschkorn, D.F.3    Lanteri, M.C.4    Biswas, H.H.5
  • 57
    • 73549099347 scopus 로고    scopus 로고
    • Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?
    • Blankson JN, (2010) Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses? Antiviral Res 85: 295-302.
    • (2010) Antiviral Res , vol.85 , pp. 295-302
    • Blankson, J.N.1
  • 58
    • 79952072932 scopus 로고    scopus 로고
    • Elite Suppressors Harbor Low Levels of Integrated HIV DNA and High Levels of 2-LTR Circular HIV DNA Compared to HIV+ Patients On and Off HAART
    • Graf EH, Mexas AM, Yu JJ, Shaheen F, Liszewski MK, et al. (2011) Elite Suppressors Harbor Low Levels of Integrated HIV DNA and High Levels of 2-LTR Circular HIV DNA Compared to HIV+ Patients On and Off HAART. PLoS Pathog 7: e1001300.
    • (2011) PLoS Pathog , vol.7
    • Graf, E.H.1    Mexas, A.M.2    Yu, J.J.3    Shaheen, F.4    Liszewski, M.K.5
  • 59
    • 77954685640 scopus 로고    scopus 로고
    • Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs
    • Berger EA, Pastan I, (2010) Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs. PLoS Pathog 6: e1000803.
    • (2010) PLoS Pathog , vol.6
    • Berger, E.A.1    Pastan, I.2
  • 60
    • 64649087732 scopus 로고    scopus 로고
    • Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR
    • Liszewski MK, Yu JJ, O'Doherty U, (2009) Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR. Methods 47: 254-260.
    • (2009) Methods , vol.47 , pp. 254-260
    • Liszewski, M.K.1    Yu, J.J.2    O'Doherty, U.3
  • 61
    • 67349132909 scopus 로고    scopus 로고
    • Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells
    • Wang GP, Levine BL, Binder GK, Berry CC, Malani N, et al. (2009) Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells. Mol Ther 17: 844-850.
    • (2009) Mol Ther , vol.17 , pp. 844-850
    • Wang, G.P.1    Levine, B.L.2    Binder, G.K.3    Berry, C.C.4    Malani, N.5
  • 62
    • 34547829263 scopus 로고    scopus 로고
    • DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations
    • Hoffmann C, Minkah N, Leipzig J, Wang G, Arens MQ, et al. (2007) DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations. Nucleic Acids Res 35: e91.
    • (2007) Nucleic Acids Res , vol.35
    • Hoffmann, C.1    Minkah, N.2    Leipzig, J.3    Wang, G.4    Arens, M.Q.5
  • 63
  • 64
    • 39749145198 scopus 로고    scopus 로고
    • Dynamic regulation of nucleosome positioning in the human genome
    • Schones DE, Cui K, Cuddapah S, Roh TY, Barski A, et al. (2008) Dynamic regulation of nucleosome positioning in the human genome. Cell 132: 887-898.
    • (2008) Cell , vol.132 , pp. 887-898
    • Schones, D.E.1    Cui, K.2    Cuddapah, S.3    Roh, T.Y.4    Barski, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.