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Volumn 65, Issue 3, 2015, Pages 226-232

AT2 receptor activities and pathophysiological implications

Author keywords

angiotensin II subtype 1 receptor; angiotensin II subtype 2 receptor; renin angiotensin system

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR AGONIST; BRADYKININ; HORMONE RECEPTOR STIMULATING AGENT; NITRIC OXIDE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CARDIOVASCULAR AGENT; NEUROPROTECTIVE AGENT;

EID: 84925466903     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000208     Document Type: Article
Times cited : (98)

References (90)
  • 1
    • 0027443482 scopus 로고
    • Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition
    • Kambayashi Y, Bardhan S, Takahashi K, et al. Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem. 1993;268:24543-25546.
    • (1993) J Biol Chem. , vol.268 , pp. 24543-25546
    • Kambayashi, Y.1    Bardhan, S.2    Takahashi, K.3
  • 2
    • 0027362063 scopus 로고
    • Expression cloning of type 2 angiotensin II receptor reveals a unique class of seventransmembrane receptors
    • Mukoyama M, Nakajima M, Horiuchi M, et al. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seventransmembrane receptors. J Biol Chem. 1993;268:24539-24542.
    • (1993) J Biol Chem. , vol.268 , pp. 24539-24542
    • Mukoyama, M.1    Nakajima, M.2    Horiuchi, M.3
  • 3
    • 1642331454 scopus 로고    scopus 로고
    • AT1 and AT2 receptor in the kidney: Role in health and disease
    • Siragy HM. AT1 and AT2 receptor in the kidney: role in health and disease. Semin Nephrol. 2004;24:93-100.
    • (2004) Semin Nephrol. , vol.24 , pp. 93-100
    • Siragy, H.M.1
  • 5
    • 18244407290 scopus 로고    scopus 로고
    • Cardiovascular and renal regulation by the angiotensin II type 2 receptor-The AT(2) receptor comes of age
    • Carey RM. Cardiovascular and renal regulation by the angiotensin II type 2 receptor-the AT(2) receptor comes of age. Hypertension. 2005; 45:840-844.
    • (2005) Hypertension. , vol.45 , pp. 840-844
    • Carey, R.M.1
  • 6
    • 80054084671 scopus 로고    scopus 로고
    • Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors
    • Bosnyak S, Jones ES, Christopoulos A, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci. 2011;121:297-303.
    • (2011) Clin Sci. , vol.121 , pp. 297-303
    • Bosnyak, S.1    Jones, E.S.2    Christopoulos, A.3
  • 7
    • 33644987169 scopus 로고    scopus 로고
    • Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat
    • Padia SH, Howell NL, Siragy HM, et al. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Hypertension. 2006;47:537-544.
    • (2006) Hypertension. , vol.47 , pp. 537-544
    • Padia, S.H.1    Howell, N.L.2    Siragy, H.M.3
  • 8
    • 0028148285 scopus 로고
    • Human type 2 angiotensin II receptor gene: Cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung
    • Koike G, Horiuchi M, Yamada T, et al. Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun. 1994;203: 1842-1850.
    • (1994) Biochem Biophys Res Commun. , vol.203 , pp. 1842-1850
    • Koike, G.1    Horiuchi, M.2    Yamada, T.3
  • 9
    • 0027716545 scopus 로고
    • A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site
    • VanAtten MK, Ensinger CL, Chiu AT, et al. A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site. J Med Chem. 1993;36:3985-3999.
    • (1993) J Med Chem. , vol.36 , pp. 3985-3999
    • Vanatten, M.K.1    Ensinger, C.L.2    Chiu, A.T.3
  • 10
    • 0029866837 scopus 로고    scopus 로고
    • Regulation of angiotensin II type 2 receptor gene by the protein kinase C-calcium pathway
    • Kijima K, Matsubara H, Murasawa S, et al. Regulation of angiotensin II type 2 receptor gene by the protein kinase C-calcium pathway. Hypertension. 1996;27:529-534.
    • (1996) Hypertension. , vol.27 , pp. 529-534
    • Kijima, K.1    Matsubara, H.2    Murasawa, S.3
  • 11
    • 0029901684 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factors induce expression of angiotensin type-2 receptor in vascular smooth muscle cells
    • Kambayashi Y, Ichild T, Inagami T. Insulin and insulin-like growth factors induce expression of angiotensin type-2 receptor in vascular smooth muscle cells. Eur J Biochem. 1996;239:558-565.
    • (1996) Eur J Biochem. , vol.239 , pp. 558-565
    • Kambayashi, Y.1    Ichild, T.2    Inagami, T.3
  • 12
    • 0028891968 scopus 로고
    • Multiple growth factors modulate mRNA expression of angiotensin II type-2 receptor in R3T3 cells
    • Ichiki T, Kambayashi Y, Inagami T. Multiple growth factors modulate mRNA expression of angiotensin II type-2 receptor in R3T3 cells. Circ Res. 1995;77:1070-1076.
    • (1995) Circ Res. , vol.77 , pp. 1070-1076
    • Ichiki, T.1    Kambayashi, Y.2    Inagami, T.3
  • 13
    • 0031304379 scopus 로고    scopus 로고
    • Function of angiotensin II type 2 receptor in the postglomerular efferent arteriole
    • Endo Y, Arima S, Yaoita H, et al. Function of angiotensin II type 2 receptor in the postglomerular efferent arteriole. Kidney Int Suppl. 1997;63:S205-S207.
    • (1997) Kidney Int Suppl. , vol.63 , pp. S205-S207
    • Endo, Y.1    Arima, S.2    Yaoita, H.3
  • 14
    • 0141962650 scopus 로고    scopus 로고
    • Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension
    • Jones A, Dhamrait SS, Payne JR, et al. Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension. Hypertension. 2003; 42:500-506.
    • (2003) Hypertension. , vol.42 , pp. 500-506
    • Jones, A.1    Dhamrait, S.S.2    Payne, J.R.3
  • 15
    • 25144461158 scopus 로고    scopus 로고
    • Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis
    • Gribouval O, Gonzales M, Neuhaus T, et al. Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat Genet. 2005;37:964-968.
    • (2005) Nat Genet. , vol.37 , pp. 964-968
    • Gribouval, O.1    Gonzales, M.2    Neuhaus, T.3
  • 16
    • 0032519908 scopus 로고    scopus 로고
    • Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes
    • Tsuchida S, Matsusaka T, Chen X, et al. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest. 1998;101: 755-760.
    • (1998) J Clin Invest. , vol.101 , pp. 755-760
    • Tsuchida, S.1    Matsusaka, T.2    Chen, X.3
  • 17
    • 0032416477 scopus 로고    scopus 로고
    • Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II
    • Oliverio MI, Kim HS, Ito M, et al. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A. 1998;95: 15496-15501.
    • (1998) Proc Natl Acad Sci U S A. , vol.95 , pp. 15496-15501
    • Oliverio, M.I.1    Kim, H.S.2    Ito, M.3
  • 18
    • 0033046261 scopus 로고    scopus 로고
    • Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men
    • Nishimura H, Yerkes E, Hohenfellner K, et al. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell. 1999;3:1-10.
    • (1999) Mol Cell. , vol.3 , pp. 1-10
    • Nishimura, H.1    Yerkes, E.2    Hohenfellner, K.3
  • 19
    • 33644874726 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution
    • Sales VL, Sukhova GK, Lopez-Ilasaca MA, et al. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation. 2005;112:3328-3336.
    • (2005) Circulation. , vol.112 , pp. 3328-3336
    • Sales, V.L.1    Sukhova, G.K.2    Lopez-Ilasaca, M.A.3
  • 20
    • 84896316697 scopus 로고    scopus 로고
    • Angiotensin II type-2 receptor-specific effects on the cardiovascular system
    • Li Y, Li XH, Yuan H. Angiotensin II type-2 receptor-specific effects on the cardiovascular system. Cardiovasc Diagn Ther. 2012;2:56-62.
    • (2012) Cardiovasc Diagn Ther. , vol.2 , pp. 56-62
    • Li, Y.1    Li, X.H.2    Yuan, H.3
  • 21
    • 78649677121 scopus 로고    scopus 로고
    • Developmental changes in AT1 and AT2 receptor-protein expression in rats
    • Yu L, Zheng M, Wang W, et al. Developmental changes in AT1 and AT2 receptor-protein expression in rats. J Renin Angiotensin Aldosterone Syst. 2010;11:214-221.
    • (2010) J Renin Angiotensin Aldosterone Syst. , vol.11 , pp. 214-221
    • Yu, L.1    Zheng, M.2    Wang, W.3
  • 22
    • 77649130229 scopus 로고    scopus 로고
    • Angiotensin II AT2 receptor regulates ureteric bud morphogenesis
    • Song R, Spera M, Garrett C, et al. Angiotensin II AT2 receptor regulates ureteric bud morphogenesis. Am J Physiol Renal Physiol. 2010;298: F807-F817.
    • (2010) Am J Physiol Renal Physiol. , vol.298 , pp. F807-F817
    • Song, R.1    Spera, M.2    Garrett, C.3
  • 23
    • 0030722325 scopus 로고    scopus 로고
    • Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney
    • Ozono R, Wang ZQ, Moore AF, et al. Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension. 1997; 30:1238-1246.
    • (1997) Hypertension. , vol.30 , pp. 1238-1246
    • Ozono, R.1    Wang, Z.Q.2    Moore, A.F.3
  • 24
    • 0033194720 scopus 로고    scopus 로고
    • Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney
    • Myiata N, Park F, Li XF, et al. Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney. Am J Physiol Renal Physiol. 1999; 277:F437-F446.
    • (1999) Am J Physiol Renal Physiol. , vol.277 , pp. F437-F446
    • Myiata, N.1    Park, F.2    Li, X.F.3
  • 25
    • 0141426710 scopus 로고    scopus 로고
    • Renal expression of angiotensin type 2 (AT2) receptors during kidney damage
    • Ruiz-Ortega M, Esteban V, Suzuki Y, et al. Renal expression of angiotensin type 2 (AT2) receptors during kidney damage. Kidney Int Suppl. 2003;86:S21-S26.
    • (2003) Kidney Int Suppl. , vol.86 , pp. S21-S26
    • Ruiz-Ortega, M.1    Esteban, V.2    Suzuki, Y.3
  • 26
    • 23944519605 scopus 로고    scopus 로고
    • How to explain the differences between renin angiotensin system modulators
    • Levy BI. How to explain the differences between renin angiotensin system modulators. Am J Hypertens. 2005;18:134S-141S.
    • (2005) Am J Hypertens. , vol.18 , pp. 134S-141S
    • Levy, B.I.1
  • 27
    • 84892400320 scopus 로고    scopus 로고
    • Preconditioning via angiotensin type 2 receptor activation improves therapeutic efficacy of bone marrow mononuclear cells for cardiac repair
    • Xu Y, Hu X, Wang L, et al. Preconditioning via angiotensin type 2 receptor activation improves therapeutic efficacy of bone marrow mononuclear cells for cardiac repair. PLoS One. 2013;8:e82997.
    • (2013) PLoS One. , vol.8
    • Xu, Y.1    Hu, X.2    Wang, L.3
  • 28
    • 0031708151 scopus 로고    scopus 로고
    • Role of AT1 and AT2 receptors in regulation of MAPKS and MKP-1 by Ang II in adult cardiac myocytes
    • Fischer TA, Singh K, Ohara DS, et al. Role of AT1 and AT2 receptors in regulation of MAPKS and MKP-1 by Ang II in adult cardiac myocytes. Am J Physiol. 1998;44:H906-H916.
    • (1998) Am J Physiol. , vol.44 , pp. H906-H916
    • Fischer, T.A.1    Singh, K.2    Ohara, D.S.3
  • 29
    • 0031862296 scopus 로고    scopus 로고
    • Molecular insights into angiotensin II type 1 and type 2 receptors-Expression, signaling and physiological function and clinical application of its antagonists
    • Matsubara H, Inada M. Molecular insights into angiotensin II type 1 and type 2 receptors-Expression, signaling and physiological function and clinical application of its antagonists. Endocr J. 1998;45: 137-150.
    • (1998) Endocr J. , vol.45 , pp. 137-150
    • Matsubara, H.1    Inada, M.2
  • 30
    • 0029814392 scopus 로고    scopus 로고
    • Intracellular third loop domain of angiotensin II type-2 receptor-Role in mediating signal transduction and cellular function
    • Hayashida W, Horiuchi M, Dzau VJ. Intracellular third loop domain of angiotensin II type-2 receptor-Role in mediating signal transduction and cellular function. J Biol Chem. 1996;271:21985-21992.
    • (1996) J Biol Chem. , vol.271 , pp. 21985-21992
    • Hayashida, W.1    Horiuchi, M.2    Dzau, V.J.3
  • 31
    • 0029666262 scopus 로고    scopus 로고
    • The AT2 receptor selectively associates with Gia2 and Gia3 in the rat fetus
    • Zhang JS, Pratt RE. The AT2 receptor selectively associates with Gia2 and Gia3 in the rat fetus. J Biol Chem. 1996;271:15026-15033.
    • (1996) J Biol Chem. , vol.271 , pp. 15026-15033
    • Zhang, J.S.1    Pratt, R.E.2
  • 32
    • 0029664773 scopus 로고    scopus 로고
    • The subtype-2 (AT2) angiotensin receptor regulates renal cycle guanosine 30, 50-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats
    • Siragy HM, Carey RM. The subtype-2 (AT2) angiotensin receptor regulates renal cycle guanosine 30, 50-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats. J Clin Invest. 1996;97:1978-1982.
    • (1996) J Clin Invest. , vol.97 , pp. 1978-1982
    • Siragy, H.M.1    Carey, R.M.2
  • 33
    • 0030610587 scopus 로고    scopus 로고
    • The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats
    • Siragy HM, Carey RM. The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest. 1997; 100:264-269.
    • (1997) J Clin Invest. , vol.100 , pp. 264-269
    • Siragy, H.M.1    Carey, R.M.2
  • 34
    • 0141997228 scopus 로고    scopus 로고
    • Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice
    • Abadir PM, Carey RM, Siragy HM. Angiotensin AT2 receptors directly stimulate renal nitric oxide in bradykinin B2-receptor-null mice. Hypertension. 2003;42:600-604.
    • (2003) Hypertension. , vol.42 , pp. 600-604
    • Abadir, P.M.1    Carey, R.M.2    Siragy, H.M.3
  • 35
    • 33748160210 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization
    • Abadir PM, Periasamy A, Carey RM, et al. Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization. Hypertension. 2006;48:316-322.
    • (2006) Hypertension. , vol.48 , pp. 316-322
    • Abadir, P.M.1    Periasamy, A.2    Carey, R.M.3
  • 36
    • 2442687960 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries
    • Batenburg WW, Garrelds IM, Bernasconi CC, et al. Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries. Circulation. 2004;109:2296-2301.
    • (2004) Circulation. , vol.109 , pp. 2296-2301
    • Batenburg, W.W.1    Garrelds, I.M.2    Bernasconi, C.C.3
  • 37
    • 33846427712 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients
    • Savoia C, Touyz RM, Volpe M, et al. Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension. 2007;49:341-346.
    • (2007) Hypertension. , vol.49 , pp. 341-346
    • Savoia, C.1    Touyz, R.M.2    Volpe, M.3
  • 38
    • 58149375072 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor stimulation: A novel option of therapeutic interference with the reninangiotensin system in myocardium infarction?
    • Kaschina E, Grzesiak A, Li J, et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the reninangiotensin system in myocardium infarction? Circulation. 2008;118: 2523-2532.
    • (2008) Circulation , vol.118 , pp. 2523-2532
    • Kaschina, E.1    Grzesiak, A.2    Li, J.3
  • 39
    • 73649119592 scopus 로고    scopus 로고
    • Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: Focus on renal damage
    • Gelosa P, Pignieri A, Fändriks L, et al. Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J Hypertens. 2009;27:2444-2451.
    • (2009) J Hypertens. , vol.27 , pp. 2444-2451
    • Gelosa, P.1    Pignieri, A.2    Fändriks, L.3
  • 40
    • 79551505061 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor stimulation inhibits early renal inflammation in renovascular hypertension
    • Matavelli LC, Huang J, Siragy HM. Angiotensin II type 2 receptor stimulation inhibits early renal inflammation in renovascular hypertension. Hypertension. 2011;57:308-313.
    • (2011) Hypertension. , vol.57 , pp. 308-313
    • Matavelli, L.C.1    Huang, J.2    Siragy, H.M.3
  • 41
    • 84870523200 scopus 로고    scopus 로고
    • Impact of the AT2 receptor agonist C21 on blood pressure and beyond
    • Foulquier S, Steckelings UM, Unger T. Impact of the AT2 receptor agonist C21 on blood pressure and beyond. Curr Hypertens Rep. 2012;14;403-409.
    • (2012) Curr Hypertens Rep. , vol.14 , pp. 403-409
    • Foulquier, S.1    Steckelings, U.M.2    Unger, T.3
  • 42
    • 0035984927 scopus 로고    scopus 로고
    • AT(2) receptor-dependent vasodilation is mediated by activation of vascular kinin generation under flow conditions
    • Katada J, Majima M. AT(2) receptor-dependent vasodilation is mediated by activation of vascular kinin generation under flow conditions. Br J Pharmacol. 2002;136:484-491.
    • (2002) Br J Pharmacol. , vol.136 , pp. 484-491
    • Katada, J.1    Majima, M.2
  • 43
    • 20144387642 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists
    • Cosentino F, Savoia C, De Paolis P, et al. Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists. Am J Hypertens. 2005;18(4 pt1):493-499.
    • (2005) Am J Hypertens. , vol.18 , Issue.4 , pp. 493-499
    • Cosentino, F.1    Savoia, C.2    De Paolis, P.3
  • 44
    • 0036771844 scopus 로고    scopus 로고
    • AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade
    • Widdop RE, Matrougui K, Levy BI, et al. AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade. Hypertension. 2002;40;516-520.
    • (2002) Hypertension. , vol.40 , pp. 516-520
    • Widdop, R.E.1    Matrougui, K.2    Levy, B.I.3
  • 45
    • 0032990242 scopus 로고    scopus 로고
    • Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor
    • Siragy HM, Inagami T, Ichiki T, et al. Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor. Proc Natl Acad Sci U S A. 1999;96:6506-6510.
    • (1999) Proc Natl Acad Sci U S A. , vol.96 , pp. 6506-6510
    • Siragy, H.M.1    Inagami, T.2    Ichiki, T.3
  • 46
    • 0028858478 scopus 로고
    • Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor
    • Ichiki T, Labosky PA, Shiota C, et al. Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature. 1995;377:748-750.
    • (1995) Nature. , vol.377 , pp. 748-750
    • Ichiki, T.1    Labosky, P.A.2    Shiota, C.3
  • 47
    • 0028885773 scopus 로고
    • Behavioral and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
    • Hein L, Barsh GS, Pratt RE, et al. Behavioral and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature. 1995;377:744-747.
    • (1995) Nature. , vol.377 , pp. 744-747
    • Hein, L.1    Barsh, G.S.2    Pratt, R.E.3
  • 48
    • 0026316523 scopus 로고
    • Radioiodinated CGP 42112A: A novel high affinity and highly selective ligand for the characterization of angiotensin at receptors
    • Whitebread SE, Taylor V, Bottari SP, et al. Radioiodinated CGP 42112A: a novel high affinity and highly selective ligand for the characterization of angiotensin AT receptors. Biochem Biophys Res Commun. 1991;181:1365-1371.
    • (1991) Biochem Biophys Res Commun. , vol.181 , pp. 1365-1371
    • Whitebread, S.E.1    Taylor, V.2    Bottari, S.P.3
  • 49
    • 0024421343 scopus 로고
    • Preliminary biochemical characterization of two angiotensin II receptor subtypes
    • Whitebread S, Mele M, Kamber B, et al. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989;163:284-291.
    • (1989) Biochem Biophys Res Commun. , vol.163 , pp. 284-291
    • Whitebread, S.1    Mele, M.2    Kamber, B.3
  • 50
    • 0026335409 scopus 로고
    • Synthesis and structureactivity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype
    • Blankley CJ, Hodges JC, Klutchko SR, et al. Synthesis and structureactivity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991;34:3248-3260.
    • (1991) J Med Chem. , vol.34 , pp. 3248-3260
    • Blankley, C.J.1    Hodges, J.C.2    Klutchko, S.R.3
  • 51
    • 0033999935 scopus 로고    scopus 로고
    • Inhibition of pressure natriuresis in mice lacking the AT2 receptor
    • Gross V, Schunck WH, Honeck H, et al. Inhibition of pressure natriuresis in mice lacking the AT2 receptor. Kidney Int. 2000;57:191-202.
    • (2000) Kidney Int. , vol.57 , pp. 191-202
    • Gross, V.1    Schunck, W.H.2    Honeck, H.3
  • 52
    • 0032930191 scopus 로고    scopus 로고
    • Protective role of the AT2 receptor in a renal wrap hypertension model
    • Siragy HM, Carey RM. Protective role of the AT2 receptor in a renal wrap hypertension model. Hypertension. 1999;33:1237-1242.
    • (1999) Hypertension. , vol.33 , pp. 1237-1242
    • Siragy, H.M.1    Carey, R.M.2
  • 53
    • 59849087336 scopus 로고    scopus 로고
    • Protective role of the angiotensina II subtype 2 receptor in blood pressure increase in obese Zucker rats
    • Siddiqui AH, Ali Q, Hussain T. Protective role of the angiotensina II subtype 2 receptor in blood pressure increase in obese Zucker rats. Hypertension. 2009;53:256-261.
    • (2009) Hypertension. , vol.53 , pp. 256-261
    • Siddiqui, A.H.1    Ali, Q.2    Hussain, T.3
  • 54
    • 0034749822 scopus 로고    scopus 로고
    • Antagonism of AT2 receptors augments Angiotensin II-induced abdominal aortic aneurysms and atherosclerosis
    • Daugherty A, Manning MW, Cassis LA. Antagonism of AT2 receptors augments Angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. Br J Pharmacol. 2001;134:865-870.
    • (2001) Br J Pharmacol. , vol.134 , pp. 865-870
    • Daugherty, A.1    Manning, M.W.2    Cassis, L.A.3
  • 55
    • 1642457221 scopus 로고    scopus 로고
    • Up-regulation of angiotensina type 2 receptor in rat thoracic aorta by pressure-overload
    • Yayama K, Horii M, Hiyoshi H, et al. Up-regulation of angiotensina type 2 receptor in rat thoracic aorta by pressure-overload. J Pharmacol Exp Ther. 2004;308:736-743.
    • (2004) J Pharmacol Exp Ther. , vol.308 , pp. 736-743
    • Yayama, K.1    Horii, M.2    Hiyoshi, H.3
  • 56
    • 8644281991 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist
    • Wan Y, Wallinder C, Plouffe B, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004;47:5995-6008.
    • (2004) J Med Chem. , vol.47 , pp. 5995-6008
    • Wan, Y.1    Wallinder, C.2    Plouffe, B.3
  • 57
    • 84883331559 scopus 로고    scopus 로고
    • Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury
    • Wagenaar GT, Laghmani el H, Fidder M, et al. Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2013;305:L341-L351.
    • (2013) Am J Physiol Lung Cell Mol Physiol. , vol.305 , pp. L341-L351
    • Wagenaar, G.T.1    Laghmani El, H.2    Fidder, M.3
  • 58
    • 79953216990 scopus 로고    scopus 로고
    • A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function
    • Jones ES, Del Borgo MP, Kirsch JF, et al. A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function. Hypertension. 2011;57:570-576.
    • (2011) Hypertension. , vol.57 , pp. 570-576
    • Jones, E.S.1    Del Borgo, M.P.2    Kirsch, J.F.3
  • 59
    • 20444372614 scopus 로고    scopus 로고
    • New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists
    • Rosenström U, Sköld C, Plouffe B, et al. New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists. J Med Chem. 2005;48:4009-4024.
    • (2005) J Med Chem. , vol.48 , pp. 4009-4024
    • Rosenström, U.1    Sköld, C.2    Plouffe, B.3
  • 60
    • 84888171158 scopus 로고    scopus 로고
    • Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure
    • Danyel LA, Schmerler P, Paulis L, et al. Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure. Integr Blood Control. 2013;6:153-161.
    • (2013) Integr Blood Control. , vol.6 , pp. 153-161
    • Danyel, L.A.1    Schmerler, P.2    Paulis, L.3
  • 61
    • 84863240765 scopus 로고    scopus 로고
    • From the first selective nonpeptide AT(2) receptor agonist to structurally related antagonists
    • Murugaiah AM, Wu X, Wallinder C, et al. From the first selective nonpeptide AT(2) receptor agonist to structurally related antagonists. J Med Chem. 2012;55:2265-2278.
    • (2012) J Med Chem. , vol.55 , pp. 2265-2278
    • Murugaiah, A.M.1    Wu, X.2    Wallinder, C.3
  • 62
    • 84865467701 scopus 로고    scopus 로고
    • Compound 21 induces vasorelaxation via an endothelium-and angiotensin II type 2 receptorindependent mechanism
    • Verdonk K, Durik M, Abd-Alla N, et al. Compound 21 induces vasorelaxation via an endothelium-and angiotensin II type 2 receptorindependent mechanism. Hypertension. 2012;60:722-729.
    • (2012) Hypertension. , vol.60 , pp. 722-729
    • Verdonk, K.1    Durik, M.2    Abd-Alla, N.3
  • 63
    • 84856120678 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats
    • Rehman A, Leibowitz A, Yamamoto N, et al. Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension. 2012;59: 291-299.
    • (2012) Hypertension. , vol.59 , pp. 291-299
    • Rehman, A.1    Leibowitz, A.2    Yamamoto, N.3
  • 64
    • 84986902830 scopus 로고    scopus 로고
    • Activation of central angiotensin type 2 receptors by compound 21 improves arterial baroreflex sensitivity in rats with heart failure
    • Gao J, Zucker IH, Gao L. Activation of central angiotensin type 2 receptors by compound 21 improves arterial baroreflex sensitivity in rats with heart failure. Am J Hypertens. 2014;27:1248-1256.
    • (2014) Am J Hypertens. , vol.27 , pp. 1248-1256
    • Gao, J.1    Zucker, I.H.2    Gao, L.3
  • 65
    • 84859885811 scopus 로고    scopus 로고
    • A nonpeptide angiotensin II type 2 receptor agonist does not attenuate postmyocardial infarction left ventricular remodeling in mice
    • Jehle AB, Xu Y, Dimaria JM, et al. A nonpeptide angiotensin II type 2 receptor agonist does not attenuate postmyocardial infarction left ventricular remodeling in mice. J Cardiovasc Pharmacol. 2012;59: 363-368.
    • (2012) J Cardiovasc Pharmacol. , vol.59 , pp. 363-368
    • Jehle, A.B.1    Xu, Y.2    Dimaria, J.M.3
  • 66
    • 77950472601 scopus 로고    scopus 로고
    • Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB
    • Rompe F, Artuc M, Hallberg A, et al. Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension. 2010;55: 924-931.
    • (2010) Hypertension. , vol.55 , pp. 924-931
    • Rompe, F.1    Artuc, M.2    Hallberg, A.3
  • 67
    • 79551499015 scopus 로고    scopus 로고
    • Gender differences in pressure-natriuresis and renal autoregulation: Role of the angiotensin type 2 receptor
    • Hilliard LM, Nematbakhsh M, Kett MM, et al. Gender differences in pressure-natriuresis and renal autoregulation: role of the angiotensin type 2 receptor. Hypertension. 2011;57:275-282.
    • (2011) Hypertension. , vol.57 , pp. 275-282
    • Hilliard, L.M.1    Nematbakhsh, M.2    Kett, M.M.3
  • 68
    • 84856097765 scopus 로고    scopus 로고
    • Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: A novel therapeutic target for hypertension
    • Hilliard LM, Jones ES, Steckelings UM, et al. Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension. Hypertension. 2012;59:409-414.
    • (2012) Hypertension. , vol.59 , pp. 409-414
    • Hilliard, L.M.1    Jones, E.S.2    Steckelings, U.M.3
  • 69
    • 84904514343 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats
    • Hilliard LM, Chow CL, Mirabito KM, et al. Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats. Hypertension. 2014;64:378-383.
    • (2014) Hypertension. , vol.64 , pp. 378-383
    • Hilliard, L.M.1    Chow, C.L.2    Mirabito, K.M.3
  • 70
    • 0035714529 scopus 로고    scopus 로고
    • Gender differences in the regulation of blood pressure
    • Reckelhoff JF. Gender differences in the regulation of blood pressure. Hypertension. 2001;37:1199-1208.
    • (2001) Hypertension. , vol.37 , pp. 1199-1208
    • Reckelhoff, J.F.1
  • 71
    • 2442570586 scopus 로고    scopus 로고
    • A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive rats
    • Silva-Antonialli MM, Tostes RC, Fernandes L, et al. A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive rats. Cardiovasc Res. 2004;62:587-593.
    • (2004) Cardiovasc Res. , vol.62 , pp. 587-593
    • Silva-Antonialli, M.M.1    Tostes, R.C.2    Fernandes, L.3
  • 72
    • 84886432625 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptormediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo
    • Brouwers S, Smolders I, Massie A, et al. Angiotensin II type 2 receptormediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo. Hypertension. 2013;62: 920-926.
    • (2013) Hypertension. , vol.62 , pp. 920-926
    • Brouwers, S.1    Smolders, I.2    Massie, A.3
  • 73
    • 84888375977 scopus 로고    scopus 로고
    • Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats
    • Ali Q, Wu Y, Hussain T. Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats. Kidney Int. 2013;84:931-939.
    • (2013) Kidney Int. , vol.84 , pp. 931-939
    • Ali, Q.1    Wu, Y.2    Hussain, T.3
  • 74
    • 0034068489 scopus 로고    scopus 로고
    • Tissue angiotensin II and endothelin modulate differently the response to flow in mesenteric resistance arteries of normotensive and spontaneously hypertensive rats
    • Matrougui K, Levy BI, Henrion D. Tissue angiotensin II and endothelin modulate differently the response to flow in mesenteric resistance arteries of normotensive and spontaneously hypertensive rats. Br J Pharmacol. 2000;130:521-526.
    • (2000) Br J Pharmacol. , vol.130 , pp. 521-526
    • Matrougui, K.1    Levy, B.I.2    Henrion, D.3
  • 75
    • 0032466957 scopus 로고    scopus 로고
    • Vasodilation mediated by angiotensin II type 2 receptor is impaired in afferent arterioles of young spontaneously hypertensive rats
    • Endo Y, Arima S, Yaoita H, et al. Vasodilation mediated by angiotensin II type 2 receptor is impaired in afferent arterioles of young spontaneously hypertensive rats. J Vasc Res. 1998;35:421-427.
    • (1998) J Vasc Res. , vol.35 , pp. 421-427
    • Endo, Y.1    Arima, S.2    Yaoita, H.3
  • 76
    • 76449117787 scopus 로고    scopus 로고
    • Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats
    • Bosnyak S, Welungoda IK, Hallberg A, et al. Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br J Pharmacol. 2010;159:709-716.
    • (2010) Br J Pharmacol. , vol.159 , pp. 709-716
    • Bosnyak, S.1    Welungoda, I.K.2    Hallberg, A.3
  • 77
    • 0035672001 scopus 로고    scopus 로고
    • Angiotensin type-2 receptormediated hypotension in angiotensin type-1 receptor blocked rats
    • Carey RM, Howell NL, Jin X-H, et al. Angiotensin type-2 receptormediated hypotension in angiotensin type-1 receptor blocked rats. Hypertension. 2001;38:1272-1277.
    • (2001) Hypertension. , vol.38 , pp. 1272-1277
    • Carey, R.M.1    Howell, N.L.2    Jin, X.-H.3
  • 78
    • 0032733920 scopus 로고    scopus 로고
    • AT(2) receptor stimulation enhances antihypertensive effect of AT(1) receptor antagonist in hypertensive rats
    • Barber MN, Sampey DB, Widdop RE. AT(2) receptor stimulation enhances antihypertensive effect of AT(1) receptor antagonist in hypertensive rats. Hypertension. 1999;34:1112-1116.
    • (1999) Hypertension. , vol.34 , pp. 1112-1116
    • Barber, M.N.1    Sampey, D.B.2    Widdop, R.E.3
  • 79
    • 54749089704 scopus 로고    scopus 로고
    • Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: Potential mechanism for sympathetic overactivity in heart failure
    • Gao L, Wang WZ, Wang W, et al. Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failure. Hypertension. 2008;52:708-714.
    • (2008) Hypertension. , vol.52 , pp. 708-714
    • Gao, L.1    Wang, W.Z.2    Wang, W.3
  • 80
    • 79956120211 scopus 로고    scopus 로고
    • Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats
    • Gao J, Zhang H, Le KD, et al. Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens. 2011;24:724-730.
    • (2011) Am J Hypertens. , vol.24 , pp. 724-730
    • Gao, J.1    Zhang, H.2    Le, K.D.3
  • 81
    • 34250796304 scopus 로고    scopus 로고
    • Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats
    • Pinaud F, Bocquet A, Dumont O, et al. Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats. Hypertension. 2007;50: 96-102.
    • (2007) Hypertension. , vol.50 , pp. 96-102
    • Pinaud, F.1    Bocquet, A.2    Dumont, O.3
  • 82
    • 84856201427 scopus 로고    scopus 로고
    • Direct angiotensin II type 2 receptor stimulation in Nv-nitro-L-arginine-methyl ester-induced hypertension: The effect on pulse wave velocity and aortic remodeling
    • Paulis L, Becker ST, Lucht K, et al. Direct angiotensin II type 2 receptor stimulation in Nv-nitro-L-arginine-methyl ester-induced hypertension: the effect on pulse wave velocity and aortic remodeling. Hypertension. 2012;59:485-492.
    • (2012) Hypertension. , vol.59 , pp. 485-492
    • Paulis, L.1    Becker, S.T.2    Lucht, K.3
  • 83
    • 84887464036 scopus 로고    scopus 로고
    • Direct AT2 receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice
    • Kljajic ST, Widdop RE, Vinh A, et al. Direct AT2 receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice. Int J Cardiol. 2013;169:281-287.
    • (2013) Int J Cardiol. , vol.169 , pp. 281-287
    • Kljajic, S.T.1    Widdop, R.E.2    Vinh, A.3
  • 84
    • 4143095706 scopus 로고    scopus 로고
    • Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation
    • Iwai M, Liu HW, Chen R, et al. Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation. Circulation. 2004; 110:843-848.
    • (2004) Circulation. , vol.110 , pp. 843-848
    • Iwai, M.1    Liu, H.W.2    Chen, R.3
  • 85
    • 65249180615 scopus 로고    scopus 로고
    • Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke
    • McCarthy CA, Vinh A, Callaway JK, et al. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke. 2009;40:1482-1489.
    • (2009) Stroke. , vol.40 , pp. 1482-1489
    • McCarthy, C.A.1    Vinh, A.2    Callaway, J.K.3
  • 86
    • 20144389630 scopus 로고    scopus 로고
    • Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury
    • Li J, Culman J, Hortnagl H, et al. Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J. 2005;19: 617-619.
    • (2005) FASEB J. , vol.19 , pp. 617-619
    • Li, J.1    Culman, J.2    Hortnagl, H.3
  • 87
    • 84856479413 scopus 로고    scopus 로고
    • Direct stimulation of angiotensin II type 2 receptor enhances spatial memory
    • Jing F, Mogi M, Sakata A, et al. Direct stimulation of angiotensin II type 2 receptor enhances spatial memory. J Cereb Blood Flow Metab. 2012; 32:248-255.
    • (2012) J Cereb Blood Flow Metab. , vol.32 , pp. 248-255
    • Jing, F.1    Mogi, M.2    Sakata, A.3
  • 88
    • 84902365547 scopus 로고    scopus 로고
    • Direct stimulation of angiotensin II type 2 receptor initiated after stroke ameliorates ischemic brain damage
    • Min LJ, Mogi M, Tsukuda K, et al. Direct stimulation of angiotensin II type 2 receptor initiated after stroke ameliorates ischemic brain damage. Am J Hypertens. 2014;27:1036-1044.
    • (2014) Am J Hypertens. , vol.27 , pp. 1036-1044
    • Min, L.J.1    Mogi, M.2    Tsukuda, K.3
  • 89
    • 84899675171 scopus 로고    scopus 로고
    • Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats
    • McCarthy CA, Vinh A, Miller AA, et al. Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. PLoS One. 2014;9:e95762.
    • (2014) PLoS One. , vol.9
    • McCarthy, C.A.1    Vinh, A.2    Miller, A.A.3
  • 90
    • 84894449097 scopus 로고    scopus 로고
    • The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke
    • Joseph JP, Mecca AP, Regenhardt RW, et al. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke. Neuropharmacology. 2014;81:134-141.
    • (2014) Neuropharmacology. , vol.81 , pp. 134-141
    • Joseph, J.P.1    Mecca, A.P.2    Regenhardt, R.W.3


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