Direct stimulation of angiotensin II type 2 receptor enhances spatial memory

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 2, 2012, Pages 248-255

  Jing, Fei ^a   Mogi, Masaki ^a   Sakata, Akiko ^a   Iwanami, Jun ^a   Tsukuda, Kana ^a   Ohshima, Kousei ^a   Min, Li Juan ^a   Steckelings, Ulrike M ^b   Unger, Thomas ^b   Dahlöf, Björn ^c   Horiuchi, Masatsugu ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

angiotensin II; AT2 receptor; cognition; Compound 21

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR AGONIST; ANGIOTENSIN DERIVATIVE; GREEN FLUORESCENT PROTEIN; ICATIBANT; MESSENGER RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN ELECTROPHYSIOLOGY; CAPILLARY DENSITY; COGNITION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL; NERVE ELONGATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPATIAL MEMORY; SYSTOLIC BLOOD PRESSURE;

ALZHEIMER DISEASE; ANIMALS; BLOOD PRESSURE; BRAIN; CELLS, CULTURED; CEREBROVASCULAR CIRCULATION; COGNITION; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; NEURITES; NEURONS; RECEPTOR, ANGIOTENSIN, TYPE 2; RNA, MESSENGER; SULFONAMIDES; SYNAPTIC POTENTIALS; THIOPHENES;

EID: 84856479413     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.133     Document Type: Article

References (29)

1. Bock HH, Jossin Y, May P, Bergner O, Herz J (2004) Apolipoprotein E receptors are required for reelininduced proteasomal degradation of the neuronal adaptor protein Disabled-1. J Biol Chem 279:33471-9 (Pubitemid 39062996)
2. Bosnyak S, Welungoda IK, Hallberg A, Alterman M, Widdop RE, Jones ES (2010) Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br J Pharmacol 159:709-16
3. Gelosa P, Pignieri A, Fandriks L, de Gasparo M, Hallberg A, Banfi C, Castiglioni L, Turolo L, Guerrini U, Tremoli E, Sironi L (2009) Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J Hypertens 27:2444-51
4. Iadecola C (2010) The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol 120:287-96
5. Iwai M, Liu HW, Chen R, Ide A, Okamoto S, Hata R, Sakanaka M, Shiuchi T, Horiuchi M (2004) Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation. Circulation 110:843-8 (Pubitemid 39096013)
6. Johren O, Dendorfer A, Dominiak P (2004) Cardiovascular and renal function of angiotensin II type-2 receptors. Cardiovasc Res 62:460-7 (Pubitemid 38648960)
7. Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria RN, Kihara T, Asada-Utsugi M, Kinoshita A, Takahashi R (2009) Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice. Brain Res 1294:202-10
8. Krege JH, Hodgin JB, Hagaman JR, Smithies O (1995) A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension 25:1111-5
9. Li J, Culman J, Hortnagl H, Zhao Y, Gerova N, Timm M, Blume A, Zimmermann M, Seidel K, Dirnagl U, Unger T (2005) Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J 19:617-9 (Pubitemid 40471263)
10. Li JM, Mogi M, Tsukuda K, Tomochika H, Iwanami J, Min LJ, Nahmias C, Iwai M, Horiuchi M (2007) Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. Mol Endocrinol 21:499-511 (Pubitemid 46184898)
11. Liu YH, Yang XP, Sharov VG, Nass O, Sabbah HN, Peterson E, Carretero OA (1997) Effects of angiotensinconverting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors. J Clin Invest 99:1926-35 (Pubitemid 27175940)
12. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K, Lo EH (2007) Cell-cell signaling in the neurovascular unit. Neurochem Res 32:2032-45 (Pubitemid 350059847)
13. Matavelli LC, Huang J, Siragy HM (2011) Angiotensin AT receptor stimulation inhibits early renal inflammation in renovascular hypertension. Hypertension 57:308-13
14. Mertens B, Vanderheyden P, Michotte Y, Sarre S (2010) Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum. Neuropharmacology 58:1038-44
15. Mogi M, Li JM, Iwanami J, Min LJ, Tsukuda K, Iwai M, Horiuchi M (2006) Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2. Hypertension 48:141-8 (Pubitemid 44297536)
16. Mogi M, Li JM, Tsukuda K, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M (2008) Telmisartan prevented cognitive decline partly due to PPAR-gamma activation. Biochem Biophys Res Commun 375:446-9
17. Nitta A, Itoh A, Hasegawa T, Nabeshima T (1994) beta-Amyloid protein-induced Alzheimer's disease animal model. Neurosci Lett 170:63-6
18. Reinecke K, Lucius R, Reinecke A, Rickert U, Herdegen T, Unger T (2003) Angiotensin II accelerates functional recovery in the rat sciatic nerve in vivo: role of the AT2 receptor and the transcription factor NF-kappaB. FASEB J 17:2094-6
19. Rompe F, Artuc M, Hallberg A, Alterman M, Stroder K, Thone-Reineke C, Reichenbach A, Schacherl J, Dahlof B, Bader M, Alenina N, Schwaninger M, Zuberbier T, Funke-Kaiser H, Schmidt C, Schunck WH, Unger T, Steckelings UM (2010) Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension 55:924-31
20. Sakata A, Mogi M, Iwanami J, Tsukuda K, Min LJ, Fujita T, Iwai M, Ito M, Horiuchi M (2009) Sex-different effect of angiotensin II type 2 receptor on ischemic brain injury and cognitive function. Brain Res 1300:14-23
21. Tateishi K, Ashihara E, Takehara N, Nomura T, Honsho S, Nakagami T, Morikawa S, Takahashi T, Ueyama T, Matsubara H, Oh H (2007) Clonally amplified cardiac stem cells are regulated by Sca-1 signaling for efficient cardiovascular regeneration. J Cell Sci 120:1791-800 (Pubitemid 46930417)
22. Tsukuda K, Mogi M, Iwanami J, Min LJ, Sakata A, Jing F, Iwai M, Horiuchi M (2009) Cognitive deficit in amyloidbeta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation. Hypertension 54:782-7
23. Tsukuda K, Mogi M, Li JM, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M (2008) Diabetes-associated cognitive impairment is improved by a calcium channel blocker, nifedipine. Hypertension 51:528-33 (Pubitemid 351156443)
24. Wan Y, Wallinder C, Plouffe B, Beaudry H, Mahalingam AK, Wu X, Johansson B, Holm M, Botoros M, Karlen A, Pettersson A, Nyberg F, Fandriks L, Gallo-Payet N, Hallberg A, Alterman M (2004) Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 47:5995-6008 (Pubitemid 39507341)
25. Watanabe T, Barker TA, Berk BC (2005) Angiotensin II and the endothelium: diverse signals and effects. Hypertension 45:163-9 (Pubitemid 40179951)
26. Wright JW, Harding JW (1995) Brain angiotensin receptor subtypes AT1, AT2, and AT4 and their functions. Regul Pept 59:269-95
27. Yayama K, Okamoto H (2008) Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide. Int Immunopharmacol 8:312-8
28. Zhu YZ, Chimon GN, Zhu YC, Lu Q, Li B, Hu HZ, Yap EH, Lee HS, Wong PT (2000) Expression of angiotensin II AT2 receptor in the acute phase of stroke in rats. Neuroreport 11:1191-4 (Pubitemid 30262955)
29. Zlokovic BV (2008) New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics 5:409-14 (Pubitemid 351952489)