Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  McCarthy, Claudia A ^a   Vinh, Antony ^a   Miller, Alyson A ^b   Hallberg, Anders ^c   Alterman, Mathias ^c   Callaway, Jennifer K ^d   Widdop, Robert E ^a  

^a MONASH UNIVERSITY   (Australia)

^b RMIT UNIVERSITY   (Australia)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR AGONIST; BRAIN DERIVED NEUROTROPHIC FACTOR; ENDOTHELIN 1; M 024; NEURON SPECIFIC NUCLEAR PROTEIN; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR COORDINATION; NERVE CELL; NEUROPROTECTION; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; AGONISTS; ANIMAL; CHEMICALLY INDUCED; HYPERTENSION; METABOLISM; REPERFUSION INJURY;

ANIMALS; ENDOTHELIN-1; HYPERTENSION; MALE; NEUROPROTECTIVE AGENTS; RATS; RECEPTOR, ANGIOTENSIN, TYPE 2; REPERFUSION INJURY;

EID: 84899675171     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095762     Document Type: Article

References (34)

1. Arnold JM, Yusuf S, Young J, Mathew J, Johnstone D, et al. (2003) Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) Study. Circulation 107: 1284-1290. (Pubitemid 36314412)
2. Chapman N, Huxley R, Anderson C, Bousser G, Chalmers J, et al. (2004) Effects of a perindopril-based blood pressure-lowering regimen on the risk of recurrent stroke according to stroke subtype and medical history. Stroke 35: 116-121. (Pubitemid 38057603)
3. de Gasparo M, Catt K, Inagami J, Wright J, Unger T (2000) International Union of Pharmacology- the angiotensin II receptors. Pharmacological Reviews 52: 415-472.
4. Li J, Culman J, Hortnagl H, Zhao Y, Gerova N, et al. (2005) Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. the FASEB journal 10.
5. Zhu M, Natarajan R, Nadler JL, Moore JM, Gelband CH, et al. (2000) Angiotensin II increases neuronal delayed rectifier K+ current: role of 12-lipoxygenase metabolites of arachidonic acid. Journal of Neurophysiology 84: 2494-2501.
6. Lu Q, Zhu YZ, Wong PT (2005) Neuroprotective effects of candesartan against cerebral ischemia in spontaneously hypertensive rats. Neuroreport 16: 1963-1967. (Pubitemid 41653523)
7. Groth W, Blume A, Golhlke P, Unger T, Culman J (2003) Chronic pretreatment with candersartan improves recovery from focal cerebral ischemia in rats. Journal of Hypertension 21: 2175-2182. (Pubitemid 38296880)
8. Ito T, Yamakawa H, Bregonzio C, Terron J, Falcon-Neri A, et al. (2002) Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist. Stroke 33: 2297-2303. (Pubitemid 35014646)
9. Faure S, Bureau A, Oudart N, Javellaud J, Fournier A, et al. (2008) Protective effect of candersartan in experimental ischemic stroke in the rat mediated by AT2 and AT4 receptors. Journal of Hypertension 26: 2008-2015.
10. Lu Q, Zhu YZ, Wong PTH (2005) Neuroprotective effect of candesartan against cerebral ischemia in spontaneously hypertensive rats. Neuropharmacology and Neurotoxicology 16: 1963-1967. (Pubitemid 41653523)
11. Iwai M, Liu HW, Chen R, Ide A, Okamoto S, et al. (2004) Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation. Circulation 110: 843-848. (Pubitemid 39096013)
12. McCarthy CA, Vinh A, Broughton BR, Sobey CG, Callaway JK, et al. (2012) Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats. Hypertension 60: 1531-1537.
13. McCarthy CA, Vinh A, Callaway JK, Widdop RE (2009) Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke 40: 1482-1489.
14. Wan Y, Wallinder C, Plouffe B, Beaudry H, Mahalingam AK, et al. (2004) Design, synthesis and biological evaluation of the first selective nonpeptide AT2 receptor agonist. Journal of Medicinal Chemistry 47: 5995-6008. (Pubitemid 39507341)
15. Bosnyak S, Welungoda IK, Hallberg A, Alterman M, Widdop RE, et al. (2010) Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. British Journal of Pharmacology 159: 709-716.
16. Kaschina E, Grzesiak A, Li J, Foryst-Ludwig A, Timm M, et al. (2008) Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 118: 2523-2532.
17. Bosnyak S, Jones ES, Christopoulos A, Aguilar MI, Thomas WG, et al. (2011) Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clinical Science (Lond) 121: 297-303.
18. Gelosa P, Pignieri A, Fändriks L, de Gasparo M, Hallberg A, et al. (2009) Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. Journal of Hypertension 27: 2444-2451.
19. Sharkey J, Ritchie I, Kelly P (1993) Perivascular microapplication of endothelin-1: A new model of focal cerebral ischaemia in the rat. Journal of Cerebral Blood Flow and Metabolism 13: 865-871. (Pubitemid 23244756)
20. Callaway JC, Knight MJ, Watkins DJ, Beart PM, Jarrott B, et al. (2000) A novel, rapid, computerised method for quantification of neuronal damage in a rat model of stroke. Journal of Neuroscience Methods 102: 53-60.
21. McCann SK, Dusting GJ, Roulston CL (2008) Early increase in Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats. Journal of Neuroscience Research 86: 2524-2534.
22. Schroeter M, Jander S, Huitinga I, Witte O, Stoll G (1997) Phagocytic response in photochemically induced infarction of rat cerebral cortex. Stroke 28: 328-386.
23. Alhusban A, Kozak A, Ergul A, Fagan SC (2013) AT1 receptor antagonism is proangiogenic in the brain: BDNF a novel mediator. Journal of Pharmacology and Experimental Therapeutics 344: 348-359.
24. Guillemin GJ, Brew BJ (2004) Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. Journal of Leukocyte Biology 75: 388-397. (Pubitemid 38316367)
25. Jones ES, Vinh A, McCarthy CA, Gaspari TA, Widdop RE (2008) AT2 receptors: functional relevance in cardiovascular disease. Pharmacology and Therapeutics 120: 292-316.
26. Lee S, Brait VH, Arumugam TV, Evans MA, Kim HA, et al. (2012) Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo. Experimental and Translational Stroke Medicine 4: 16.
27. Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience 8: 57-69. (Pubitemid 46011999)
28. Hu X, Li P, Guo Y, Wang H, Leak RK, et al. (2012) Microglia/Macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 43: 3063-3070.
29. David S, Kroner A (2011) Repertoire of microglial and macrophage responses after spinal cord injury. Nature Reviews Neuroscience 12: 388-399.
30. Batchelor PE, Porritt MJ, Martinello P, Parish CL, Liberatore GT, et al. (2002) Macrophages and microglia produce local trophic gradients that stimulate axonal sprouting toward but not beyond the wound edge. Molecular and Cellular Neurosciences 21: 436-453. (Pubitemid 36062730)
31. Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nature Neuroscience 10: 1387-1394.
32. Streit WJ, Conde JR, Fendrick SE, Flanary BE, Mariani CL (2005) Role of microglia in the central nervous system's immune response. Neurological Research 27: 685-691. (Pubitemid 41513077)
33. Krikov M, Thone-Reineke C, Muller S, Villringer A, Unger T (2008) Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF/TrkB system in rats. Journal of Hypertension 26: 544-552. (Pubitemid 351317265)
34. Namsolleck P, Boato F, Schwengel K, Paulis L, Matho KS, et al. (2013) AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression. Neurobiology of Disease 51: 177-191.