-
1
-
-
0037160968
-
Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (life): A randomised trial against atenolol
-
Dahlof B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, Fyhrquist F, Ibsen H, Kristiansson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995-1003.
-
(2002)
Lancet
, vol.359
, pp. 995-1003
-
-
Dahlof, B.1
Devereux, R.B.2
Kjeldsen, S.E.3
Julius, S.4
Beevers, G.5
De Faire, U.6
Fyhrquist, F.7
Ibsen, H.8
Kristiansson, K.9
Lederballe-Pedersen, O.10
Lindholm, L.H.11
Nieminen, M.S.12
Omvik, P.13
Oparil, S.14
Wedel, H.15
-
2
-
-
20444427156
-
Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention: Principal results of a prospective randomized controlled study (moses)
-
Schrader J, Luders S, Kulschewski A, Hammersen F, Plate K, Berger J, Zidek W, Dominiak P, Diener HC. Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention: principal results of a prospective randomized controlled study (MOSES). Stroke 2005; 36: 1218-1226.
-
(2005)
Stroke
, vol.36
, pp. 1218-1226
-
-
Schrader, J.1
Luders, S.2
Kulschewski, A.3
Hammersen, F.4
Plate, K.5
Berger, J.6
Zidek, W.7
Dominiak, P.8
Diener, H.C.9
-
3
-
-
79959736871
-
Role of angiotensin ii receptor subtype activation in cognitive function and ischaemic brain damage
-
Horiuchi M, Mogi M. Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damage. Br J Pharmacol 2011; 163: 1122-1130.
-
(2011)
Br J Pharmacol
, vol.163
, pp. 1122-1130
-
-
Horiuchi, M.1
Mogi, M.2
-
4
-
-
77149162034
-
Treatment with angiotensin receptor blockers before stroke could exert a favourable effect in acute cerebral infarction
-
Fuentes B, Fernandez-Dominguez J, Ortega-Casarrubios MA, SanJose B, Martinez-Sanchez P, Diez-Tejedor E. Treatment with angiotensin receptor blockers before stroke could exert a favourable effect in acute cerebral infarction. J Hypertens 2010; 28: 575-581.
-
(2010)
J Hypertens
, vol.28
, pp. 575-581
-
-
Fuentes, B.1
Fernandez-Dominguez, J.2
Ortega-Casarrubios, M.A.3
SanJose, B.4
Martinez-Sanchez, P.5
Diez-Tejedor, E.6
-
5
-
-
74949131237
-
Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis
-
Li NC, Lee A, Whitmer RA, Kivipelto M, Lawler E, Kazis LE, Wolozin B. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 2010; 340: b5465.
-
(2010)
BMJ
, vol.340
-
-
Li, N.C.1
Lee, A.2
Whitmer, R.A.3
Kivipelto, M.4
Lawler, E.5
Kazis, L.E.6
Wolozin, B.7
-
6
-
-
4143095706
-
Possible inhibition of focal cerebral ischemia by angiotensin ii type 2 receptor stimulation
-
Iwai M, Liu HW, Chen R, Ide A, Okamoto S, Hata R, Sakanaka M, Shiuchi T, Horiuchi M. Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation. Circulation 2004; 110: 843-848.
-
(2004)
Circulation
, vol.110
, pp. 843-848
-
-
Iwai, M.1
Liu, H.W.2
Chen, R.3
Ide, A.4
Okamoto, S.5
Hata, R.6
Sakanaka, M.7
Shiuchi, T.8
Horiuchi, M.9
-
7
-
-
20144389630
-
Angiotensin at2 receptor protects against cerebral ischemia-induced neuronal injury
-
Li J, Culman J, Hortnagl H, Zhao Y, Gerova N, Timm M, Blume A, Zimmermann M, Seidel K, Dirnagl U, Unger T. Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J 2005; 19: 617-619.
-
(2005)
FASEB J
, vol.19
, pp. 617-619
-
-
Li, J.1
Culman, J.2
Hortnagl, H.3
Zhao, Y.4
Gerova, N.5
Timm, M.6
Blume, A.7
Zimmermann, M.8
Seidel, K.9
Dirnagl, U.10
Unger, T.11
-
8
-
-
8644281991
-
Design, syn thesis, and biological evaluation of the first selective nonpeptide at2 receptor agonist
-
Wan Y, Wallinder C, Plouffe B, Beaudry H, Mahalingam AK, Wu X, Johansson B, Holm M, Botoros M, Karlen A, Pettersson A, Nyberg F, Fandriks L, Gallo-Payet N, Hallberg A, Alterman M. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 2004; 47: 5995-6008.
-
(2004)
J Med Chem
, vol.47
, pp. 5995-6008
-
-
Wan, Y.1
Wallinder, C.2
Plouffe, B.3
Beaudry, H.4
Mahalingam, A.K.5
Wu, X.6
Johansson, B.7
Holm, M.8
Botoros, M.9
Karlen, A.10
Pettersson, A.11
Nyberg, F.12
Fandriks, L.13
Gallo-Payet, N.14
Hallberg, A.15
Alterman, M.16
-
9
-
-
77749273888
-
Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (at2): Implications for at2 receptor research and therapeutic potential
-
Unger T, Dahlof B. Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potential. J Renin Angiotensin Aldosterone Syst 2010; 11: 75-77.
-
(2010)
J Renin Angiotensin Aldosterone Syst
, vol.11
, pp. 75-77
-
-
Unger, T.1
Dahlof, B.2
-
10
-
-
73649119592
-
Stimulation of at2 receptor exerts beneficial effects in stroke-prone rats: Focus on renal damage
-
Gelosa P, Pignieri A, Fandriks L, de Gasparo M, Hallberg A, Banfi C, Castiglioni L, Turolo L, Guerrini U, Tremoli E, Sironi L. Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J Hypertens 2009; 27: 2444-2451.
-
(2009)
J Hypertens
, vol.27
, pp. 2444-2451
-
-
Gelosa, P.1
Pignieri, A.2
Fandriks, L.3
De Gasparo, M.4
Hallberg, A.5
Banfi, C.6
Castiglioni, L.7
Turolo, L.8
Guerrini, U.9
Tremoli, E.10
Sironi, L.11
-
11
-
-
84856479413
-
Direct stimulation of angiotensin ii type 2 receptor enhances spatial memory
-
Jing F, Mogi M, Sakata A, Iwanami J, Tsukuda K, Ohshima K, Min LJ, Steckelings UM, Unger T, Dahlof B, Horiuchi M. Direct stimulation of angiotensin II type 2 receptor enhances spatial memory. J Cereb Blood Flow Metab 2012; 32: 248-255.
-
(2012)
J Cereb Blood Flow Metab
, vol.32
, pp. 248-255
-
-
Jing, F.1
Mogi, M.2
Sakata, A.3
Iwanami, J.4
Tsukuda, K.5
Ohshima, K.6
Min, L.J.7
Steckelings, U.M.8
Unger, T.9
Dahlof, B.10
Horiuchi, M.11
-
12
-
-
84870245689
-
Angiotensin ii type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats
-
McCarthy CA, Vinh A, Broughton BR, Sobey CG, Callaway JK, Widdop RE. Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats. Hypertension 2012; 60: 1531-1537.
-
(2012)
Hypertension
, vol.60
, pp. 1531-1537
-
-
McCarthy, C.A.1
Vinh, A.2
Broughton, B.R.3
Sobey, C.G.4
Callaway, J.K.5
Widdop, R.E.6
-
13
-
-
84870240182
-
Angiotensin ii type 2 receptor agonists as therapies for ischemic stroke
-
Dorrance AM. Angiotensin II type 2 receptor agonists as therapies for ischemic stroke. Hypertension 2012; 60: 1391-1392.
-
(2012)
Hypertension
, vol.60
, pp. 1391-1392
-
-
Dorrance, A.M.1
-
14
-
-
33645081754
-
Hydrogen sulfide is a mediator of cerebral ischemic damage
-
Qu K, Chen CP, Halliwell B, Moore PK, Wong PT. Hydrogen sulfide is a mediator of cerebral ischemic damage. Stroke 2006; 37: 889-893.
-
(2006)
Stroke
, vol.37
, pp. 889-893
-
-
Qu, K.1
Chen, C.P.2
Halliwell, B.3
Moore, P.K.4
Wong, P.T.5
-
15
-
-
0027945658
-
Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
-
Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994; 265: 1883-1885.
-
(1994)
Science
, vol.265
, pp. 1883-1885
-
-
Huang, Z.1
Huang, P.L.2
Panahian, N.3
Dalkara, T.4
Fishman, M.C.5
Moskowitz, M.A.6
-
16
-
-
73949100419
-
Sex-different effect of angiotensin ii type 2 receptor on ischemic brain injury and cognitive function
-
Sakata A, Mogi M, Iwanami J, Tsukuda K, Min LJ, Fujita T, Iwai M, Ito M, Horiuchi M. Sex-different effect of angiotensin II type 2 receptor on ischemic brain injury and cognitive function. Brain Res 2009;1300: 14-23.
-
(2009)
Brain Res
, vol.1300
, pp. 14-23
-
-
Sakata, A.1
Mogi, M.2
Iwanami, J.3
Tsukuda, K.4
Min, L.J.5
Fujita, T.6
Iwai, M.7
Ito, M.8
Horiuchi, M.9
-
17
-
-
0036141820
-
Upregulation of nox-based nad(p)h oxidases in restenosis after carotid injury
-
Szocs K, Lassegue B, Sorescu D, Hilenski LL, Valppu L, Couse TL, Wilcox JN, Quinn MT, Lambeth JD, Griendling KK. Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol 2002; 22: 21-27.
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 21-27
-
-
Szocs, K.1
Lassegue, B.2
Sorescu, D.3
Hilenski, L.L.4
Valppu, L.5
Couse, T.L.6
Wilcox, J.N.7
Quinn, M.T.8
Lambeth, J.D.9
Griendling, K.K.10
-
18
-
-
33745305219
-
Long-term l-name treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats
-
Kalayci R, Kaya M, Ahishali B, Arican N, Elmas I, Kucuk M. Long-term L-NAME treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats. Life Sci 2006; 79: 16-20.
-
(2006)
Life Sci
, vol.79
, pp. 16-20
-
-
Kalayci, R.1
Kaya, M.2
Ahishali, B.3
Arican, N.4
Elmas, I.5
Kucuk, M.6
-
19
-
-
34247874753
-
Absence of the chemokine receptor ccr2 protects against cerebral ischemia/reperfusion injury in mice
-
Dimitrijevic OB, Stamatovic SM, Keep RF, Andjelkovic AV. Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice. Stroke 2007; 38: 1345-1353.
-
(2007)
Stroke
, vol.38
, pp. 1345-1353
-
-
Dimitrijevic, O.B.1
Stamatovic, S.M.2
Keep, R.F.3
Andjelkovic, A.V.4
-
20
-
-
33745162185
-
Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease
-
Ferrario CM, Strawn WB. Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. Am J Cardiol 2006; 98: 121-128.
-
(2006)
Am J Cardiol
, vol.98
, pp. 121-128
-
-
Ferrario, C.M.1
Strawn, W.B.2
-
21
-
-
80052044652
-
Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models
-
Thoene-Reineke C, Rumschussel K, Schmerbach K, Krikov M, Wengenmayer C, Godes M, Mueller S, Villringer A, Steckelings U, Namsolleck P, Unger T. Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models. PLoS One 2011; 6: e23646.
-
(2011)
PLoS One
, vol.6
-
-
Thoene-Reineke, C.1
Rumschussel, K.2
Schmerbach, K.3
Krikov, M.4
Wengenmayer, C.5
Godes, M.6
Mueller, S.7
Villringer, A.8
Steckelings, U.9
Namsolleck, P.10
Unger, T.11
-
22
-
-
77954954191
-
Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice
-
Iwanami J, Mogi M, Tsukuda K, Min LJ, Sakata A, Jing F, Iwai M, Horiuchi M. Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice. J Hypertens 2010; 28: 1730-1737.
-
(2010)
J Hypertens
, vol.28
, pp. 1730-1737
-
-
Iwanami, J.1
Mogi, M.2
Tsukuda, K.3
Min, L.J.4
Sakata, A.5
Jing, F.6
Iwai, M.7
Horiuchi, M.8
-
23
-
-
0038261970
-
The access study: Evaluation of acute candesartan cilexetil therapy in stroke survivors
-
Schrader J, Luders S, Kulschewski A, Berger J, Zidek W, Treib J, Einhaupl K, Diener HC, Dominiak P. The ACCESS study: evaluation of acute candesartan cilexetil therapy in stroke survivors. Stroke 2003; 34: 1699-1703.
-
(2003)
Stroke
, vol.34
, pp. 1699-1703
-
-
Schrader, J.1
Luders, S.2
Kulschewski, A.3
Berger, J.4
Zidek, W.5
Treib, J.6
Einhaupl, K.7
Diener, H.C.8
Dominiak, P.9
-
24
-
-
79952103780
-
The angiotensinreceptor blocker candesartan for treatment of acute stroke (scast): A randomised, placebo-controlled, double-blind trial
-
Sandset EC, Bath PM, Boysen G, Jatuzis D, Korv J, Luders S, Murray GD, Richter PS, Roine RO, Terent A, Thijs V, Berge E. The angiotensinreceptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial. Lancet 2011; 377: 741-750.
-
(2011)
Lancet
, vol.377
, pp. 741-750
-
-
Sandset, E.C.1
Bath, P.M.2
Boysen, G.3
Jatuzis, D.4
Korv, J.5
Luders, S.6
Murray, G.D.7
Richter, P.S.8
Roine, R.O.9
Terent, A.10
Thijs, V.11
Berge, E.12
-
25
-
-
0037146917
-
Changes of oxidative stress, inos activity and neutrophil infiltration in severe transient focal cerebral ischemia in rats
-
Lerouet D, Beray-Berthat V, Palmier B, Plotkine M, Margaill I. Changes of oxidative stress, iNOS activity and neutrophil infiltration in severe transient focal cerebral ischemia in rats. Brain Res 2002;20: 166-175.
-
(2002)
Brain Res
, vol.20
, pp. 166-175
-
-
Lerouet, D.1
Beray-Berthat, V.2
Palmier, B.3
Plotkine, M.4
Margaill, I.5
-
26
-
-
0036714543
-
Quantitative real-time rt-pcr analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury
-
Berti R, Williams AJ, Moffett JR, Hale SL, Velarde LC, Elliott PJ, Yao C, Dave JR, Tortella FC. Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury. J Cereb Blood Flow Metab. 2002; 22: 1068-1079.
-
(2002)
J Cereb Blood Flow Metab.
, vol.22
, pp. 1068-1079
-
-
Berti, R.1
Williams, A.J.2
Moffett, J.R.3
Hale, S.L.4
Velarde, L.C.5
Elliott, P.J.6
Yao, C.7
Dave, J.R.8
Tortella, F.C.9
-
27
-
-
84860224428
-
Peroxisome proliferator-activated receptor-gamma activation with angiotensin ii type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice
-
Min LJ, Mogi M, Shudou M, Jing F, Tsukuda K, Ohshima K, Iwanami J, Horiuchi M. Peroxisome proliferator-activated receptor-gamma activation with angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice. Hypertension 2012; 59: 1079-1088.
-
(2012)
Hypertension
, vol.59
, pp. 1079-1088
-
-
Min, L.J.1
Mogi, M.2
Shudou, M.3
Jing, F.4
Tsukuda, K.5
Ohshima, K.6
Iwanami, J.7
Horiuchi, M.8
-
28
-
-
65249180615
-
Angiotensin at2 receptor stimulation causes neuroprotection in a conscious rat model of stroke
-
McCarthy CA, Vinh A, Callaway JK, Widdop RE. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke 2009; 40: 1482-1489.
-
(2009)
Stroke
, vol.40
, pp. 1482-1489
-
-
McCarthy, C.A.1
Vinh, A.2
Callaway, J.K.3
Widdop, R.E.4
-
29
-
-
33846563996
-
Angiotensin ii-induced neural differentiation via angiotensin ii type 2(at2) receptor-mms2 cascade involving interaction between at2 receptor-interacting protein and src homology 2 domain-containing protein-tyrosine phosphatase 1
-
Li JM, Mogi M, Tsukuda K, Tomochika H, Iwanami J, Min LJ, Nahmias C, Iwai M, Horiuchi M. Angiotensin II-induced neural differentiation via angiotensin II type 2(AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. Mol Endocrinol 2007; 21: 499-511.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 499-511
-
-
Li, J.M.1
Mogi, M.2
Tsukuda, K.3
Tomochika, H.4
Iwanami, J.5
Min, L.J.6
Nahmias, C.7
Iwai, M.8
Horiuchi, M.9
-
30
-
-
84872804111
-
At2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating bdnf expression
-
Namsolleck P, Boato F, Schwengel K, Paulis L, Matho K, Geurts N, Thone-Reineke C, Lucht K, Seidel K, Hallberg A, Dahlof B, Unger T, Hendrix S, Steckelings UM. AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression. Neurobiol Dis 2013; 51: 177-191.
-
(2013)
Neurobiol Dis
, vol.51
, pp. 177-191
-
-
Namsolleck, P.1
Boato, F.2
Schwengel, K.3
Paulis, L.4
Matho, K.5
Geurts, N.6
Thone-Reineke, C.7
Lucht, K.8
Seidel, K.9
Hallberg, A.10
Dahlof, B.11
Unger, T.12
Hendrix, S.13
Steckelings, U.M.14
-
31
-
-
79956120211
-
Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats
-
Gao J, Zhang H, Le KD, Chao J, Gao L. Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens 2011; 24: 724-730.
-
(2011)
Am J Hypertens
, vol.24
, pp. 724-730
-
-
Gao, J.1
Zhang, H.2
Le, K.D.3
Chao, J.4
Gao, L.5
-
32
-
-
77950955706
-
Direct angiotensin ii type 2 receptor stimulation decreases dopamine synthesis in the rat striatum
-
Mertens B, Vanderheyden P, Michotte Y, Sarre S. Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum. Neuropharmacology 2010; 58: 1038-1044.
-
(2010)
Neuropharmacology
, vol.58
, pp. 1038-1044
-
-
Mertens, B.1
Vanderheyden, P.2
Michotte, Y.3
Sarre, S.4
-
33
-
-
34848816196
-
Norepinephrine depletion facilitates recovery of function after focal ischemia in the rat
-
Windle V, Power A, Corbett D. Norepinephrine depletion facilitates recovery of function after focal ischemia in the rat. Eur J Neurosci 2007; 26: 1822-1831.
-
(2007)
Eur J Neurosci
, vol.26
, pp. 1822-1831
-
-
Windle, V.1
Power, A.2
Corbett, D.3
-
34
-
-
84856428103
-
Levodopa treatment improves functional recovery after experimental stroke
-
Ruscher K, Kuric E, Wieloch T. Levodopa treatment improves functional recovery after experimental stroke. Stroke 2012; 43: 507-513.
-
(2012)
Stroke
, vol.43
, pp. 507-513
-
-
Ruscher, K.1
Kuric, E.2
Wieloch, T.3
|