Compound 21 induces vasorelaxation via an endothelium-and angiotensin II type 2 receptor-independent mechanism

Hypertension

Volumn 60, Issue 3, 2012, Pages 722-729

  Verdonk, Koen ^a   Durik, Matej ^a   Abd Alla, Nalina ^a   Batenburg, Wendy W ^a   Van Den Bogaerdt, Antoon J ^b   Van Veghel, Richard ^a   Roks, Anton J M ^a   Danser, A H Jan ^a   Van Esch, Joep H M ^a  

^a Department of Internal Medicine   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

angiotensin II; AT2 receptor; compound 21; coronary circulation; Langendorff model; mouse; rat; vasorelaxation

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANGIOTENSIN 2 RECEPTOR; C 21; CALCIUM IONOPHORE; CYCLIC GMP; ENDOTHELIUM DERIVED RELAXING FACTOR; GUANYLATE CYCLASE; IRBESARTAN; PHENYLEPHRINE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CALCIUM TRANSPORT; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY BLOOD VESSEL; FEMALE; HUMAN; HYPERTENSION; ILIAC ARTERY; IN VITRO STUDY; ISOLATED HEART; MALE; MESENTERIC ARTERY; MOUSE; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADULT; ANGIOTENSIN II TYPE 2 RECEPTOR BLOCKERS; ANIMALS; BIPHENYL COMPOUNDS; CALCIUM; CALCIUM IONOPHORES; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; ILIAC ARTERY; IMIDAZOLES; MALE; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; MODELS, ANIMAL; PHENYLEPHRINE; PYRIDINES; RATS; RATS, INBRED SHR; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 2; SULFONAMIDES; TETRAZOLES; THIOPHENES; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 84865467701     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.196022     Document Type: Article

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