The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke

Neuropharmacology

Volumn 81, Issue , 2014, Pages 134-141

  Joseph, Jason P ^a   Mecca, Adam P ^a   Regenhardt, Robert W ^a   Bennion, Douglas M ^a   Rodríguez, Vermali ^a   Desland, Fiona ^a   Patel, Neal A ^a   Pioquinto, David J ^a   Unger, Thomas ^b   Katovich, Michael J ^a   Steckelings, U Muscha ^c   Sumners, Colin ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Angiotensin type 2 receptor; Chemokine; Compound 21; Endothelin 1; Ischemia; Stroke

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN II DERIVATIVE; ANGIOTENSIN II RECEPTOR AGONIST; ANGIOTENSIN RECEPTOR; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; COMPOUND 21; ENDOTHELIN 1; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; CD11B ANTIGEN; CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; IMIDAZOLE DERIVATIVE; N-BUTYLOXYCARBONYL-3-(4-IMIDAZOL-1-YLMETHYLPHENYL)-5-ISOBUTYLTHIOPHENE-2-SULFONAMIDE; PEROXIDASE; PYRIDINE DERIVATIVE; SULFONAMIDE; THIOPHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; ANIMAL; BRAIN CIRCULATION; BRAIN INFARCTION; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; STROKE; TIME; TOXICITY;

ANGIOTENSIN II TYPE 2 RECEPTOR BLOCKERS; ANIMALS; ANTIGENS, CD11B; BRAIN INFARCTION; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; GLIAL FIBRILLARY ACIDIC PROTEIN; IMIDAZOLES; MALE; NITRIC OXIDE SYNTHASE TYPE II; PEROXIDASE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; STROKE; SULFONAMIDES; THIOPHENES; TIME FACTORS;

EID: 84894449097     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.044     Document Type: Article

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