Design, synthesis, and biological evaluation, of the first selective nonpeptide AT2 receptor agonist

Journal of Medicinal Chemistry

Volumn 47, Issue 24, 2004, Pages 5995-6008

  Wan, Yiqian ^a   Wallinder, Charlotta ^a   Plouffe, Bianca ^b   Beaudry, Hélène ^b   Mahalingam, A K ^a   Wu, Xiongyu ^a   Johansson, Berndt ^c   Holm, Mathias ^b   Botoros, Milad ^a   Karlén, Anders ^a   Pettersson, Anders ^c   Nyberg, Fred ^a   Fändriks, Lars ^c   Gallo Payet, Nicole ^b   Hallberg, Anders ^a   Alterman, Mathias ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF SHERBROOKE   (Canada)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 [2' [(BUTOXYCARBONYL)AMINOSULFONYL] 5' (3 METHOXYBENZYL) 4 BIPHENYLYLMETHYL] 2 ETHYL 5,7 DIMETHYL 3H IMIDAZO[4,5 B]PYRIDINE; 6 ANILINO 5,8 QUINOLINEQUINONE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR AGONIST; ANTIHYPERTENSIVE AGENT; KT 5823; L 162313; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; N BUTYLOXYCARBONYL 3 (4 IMIDAZOL 1 YLMETHYLPHENYL) 5 ISOBUTYLTHIOPHENE 2 SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DUODENUM SECRETION; ENZYME ACTIVATION; HYPERTENSION; LIVER CELL MEMBRANE; MALE; MEAN ARTERIAL PRESSURE; NERVE FIBER GROWTH; NONHUMAN; RAT; RAT STRAIN; RECEPTOR AFFINITY; SWINE;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; BICARBONATES; BIOLOGICAL AVAILABILITY; CELL LINE; DRUG DESIGN; ENZYME ACTIVATION; FEMALE; HALF-LIFE; INTESTINAL MUCOSA; LIVER; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR MIMICRY; NEURITES; PEPTIDES; RADIOLIGAND ASSAY; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 2; SULFONAMIDES; SWINE; THIOPHENES; UTERUS;

EID: 8644281991     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049715t     Document Type: Article

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