Molecular insights into angiotensin II type I and type 2 receptors: Expression, signaling and physiological function and clinical application of its antagonists

Endocrine Journal

Volumn 45, Issue 2, 1998, Pages 137-150

  Matsubara, Hiroaki ^a   Inada, Mitsuo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; CANDESARTAN HEXETIL; LOSARTAN; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; VALSARTAN;

BLOOD PRESSURE; DNA SEQUENCE; GENE SEQUENCE; HEART RATE; RECEPTOR BINDING; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; TRANSCRIPTION REGULATION;

EID: 0031862296     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.45.137     Document Type: Review

References (94)

1. Paul M, Bachman J, Ganten D (1992) The tissue renin-angiotensin system in cardiovascular disease. Trends Cardiovasc Med 2: 94-99.
2. Maschio G, and APRI study Group (1996) Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. New Eng J Med 334: 939-945.
3. The CONSENSUS trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure. N Engl J Med 315: 1429-1435.
4. The SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325: 293-302.
5. Inagami T, Kitami Y (1994) Angiotensin II receptor: Molecular cloning, functions, and regulation. Hypertens Res 17: 87-97.
6. Timmermans PBMWM, Wong PC, Chiu AT, Herbin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JAM, Smith RD (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 45: 205-251.
7. Sugaya T, Nishimatsu S, Tanimoto K, Takimoto E, Yamagishi T, Imamura K, Goto S, Imaizumi K, Hisada Y, Otsuka A, Fukamizu A, Murakami K (1995) Angiotensin II type la receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem 270: 18719-18722.
8. Ito M, Olivero MI, Mannon PJ, Best CF, Maeda N, Smithies O, Coffman TM (1995) Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci USA 92: 3521-3525.
9. Ichiki T, Labosky PA, Shiota C, Okuyama S, Inagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BLM, Inagami T (1995) Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature 377: 748-750.
10. Hein L, Barsh GS, Pratt RE, Dzau VJ, Koblik BK (1995) Behavioral and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature 377: 744-747.
11. Bernstein KE, Alexander W (1992) Counterpoint: Molecular analysis of the angiotensin II receptor. Endocr Rev 13: 381-386.
12. Sasaki K, Yamano Y, Bardhan S, Iwai N, Murray JJ, Hasegawa M, Matsuda Y, Inagami T (1991) Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin type 1 receptor. Nature 351: 230-233.
13. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Berstein KE (1991) Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 351: 233-236.
14. Iwai N, Inagami T (1992) Identification of two subtypes in the rat type 1 angiotensin II receptor. FEBS lett 298: 257-260.
15. Sandberg K, Ji H, Clark A, Shapira H, Catt KJ (1992) Cloning and expression of a novel angiotensin II receptor subtype. J Biol Chem 267: 9455-9458.
16. Kakar SS, Sellers JC, Devor DC, Musgrove LC, Neil JD (1992) Angiotensin II type a receptor subtype cDNAs: Differential tissue expression and hormonal regulation. Biochem Biophys Res Commun 183:1090-1096.
17. Elton TS, Stephan CC, Taylor GR, Kimball MG, Martin MM, Durand JN (1992) Isolation of two distinct type 1 angiotensin II receptor genes. Biochem Biophys Res Commun 184: 1067-1073.
18. Murasawa S, Matsubara H, Urakami M, Inada M (1993) Regulatory elements that mediate expression of the gene for the angiotensin II typela receptor for the rat. J Biol Chem 268: 26996-27003.
19. Murasawa S, Matsubara H, Mori Y, Kijima K, Maruyama K, Inada M (1995) Identification of a negative cis-regulatory element and trans-acting protein that inhibit transcription of the angiotensin II type 1a receptor gene. J Biol Chem 270: 24282-24286.
20. Sato A, Suzuki H, Murakami M, Nakazato Y, Iwaita Y, Saruta T (1994) Glucocorticoid increases angiotensin II type 1 receptor and its gene expression. Hypertension 23: 25-30.
21. Murasawa S, Matsubara H, Kanasaki M, Kijima K, Maruyama K, Tsukaguchi H, Mori Y, Inada M (1995) Characterization of glucocorticoid response element of rat angiotensin II type 1 receptor gene. Biochem Biophys Res Commun 209: 832-840.
22. Guo DF, Uno S, Ishihata A, Nakamura N, Inagami T (1995) Identification of a cis-acting glucocorticoid response element in the rat angiotensin II type 1A promoter. Cir Res 77: 249-257.
23. Guo DF, Inagami T (1994) Epidermal growth factor-enhanced human angiotensin II type 1 receptor. Hypertension 23: 1023-1035.
24. Chen X, Nishimura J, Hasna J, Kobayashi S, Shikasho T, Kanaide H (1994) Protein kinase C and protein kinase A regulate the expression of angiotensin II receptor mRNA in smooth muscle cells. Europ J Pharm 267: 175-183.
25. Suzuki J, Matsubara H, Urakami M, Inada M (1993) Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy. Circ Res 73: 439-447.
26. Fujii N, Tanaka M, Ohnishi J, Yukawa K, Takimoto E, Shimada S, Naruse M, Sugiyama F, Yamagi K, Murakami K, Miyazaki H (1995) Alterations of angiotensin II receptor contents in hypertrophied hearts. Biochem Biophys Res Commun 212: 326-333.
27. Herzig TC, Jobe SM, Aoki H, Molkentin JD, Cowley AW, Izumo S, Markham BE (1997) Angiotensin II type 1a receptor gene expression in the heart: API and GATA-4 participate in the response to pressure overload. Proc Natl Acad Sci USA 94: 7543-7548.
28. Iwai N, Inagami T (1992) Regulation of the expression of the rat angiotensin II receptor mRNA. Biochem Biophys Res Commun 182: 1094-1099.
29. Kitami Y, Okura T, Marumoto K, Hiwada K (1992) Differential gene expression and regulation of type-1 angiotensin II receptor subtypes in the rat. Biochem Biophys Res Commun 188: 446-452.
30. Kitami Y, Okura T, Wakamiya R, Hiwada K (1992) Regulation of the gene expression of type 1 angiotensin II receptor in spontaneously hypertensive rats. Blood Pressure 1 (suppl 3): 12-16.
31. Parola AL, Kobilka BK (1994) The peptide product of a 5′ leader cistron in the β2 adrenergic receptor mRNA inhibits receptor synthesis. J Biol Chem 269: 4497-4505.
32. Mori Y, Matsubara H, Murasawa S, Kijima K, Maruyama K, Tsukaguchi H, Iwasaka T, Inda M (1996) Translational regulation of angiotensin II type 1A receptor: Role of upstream AUG triplets. Hypertension 28: 810-817.
33. Curnow KM, Pascoe L, Davies E, White PC, Corvol P, Clauser E (1995) Alternatively spliced human type-1 angiotensin II receptor (AT1) mRNAs are translated at different efficiencies and encode two receptor isoforms. Mol Endocrinol 9: 1250-1262.
34. Morrero MB, Paxton WG, Duff JL, Berk BC, Bernstein KE (1994) Angiotensin II stimulates tyrosine phosphorylation of phospholipase Cγ1 in vascular smooth muscle cells. J Biol Chem 269: 10935-10939.
35. c-src antibodies inhibits the angiotensin II activation of phospholipase C-γ1 in rat aortic smooth muscle cells. J Biol Chem 270: 15734-15738.
36. 6oc-src in vascular smooth muscle cells. Circ Res 77: 1053-1059.
37. Eguchi S, Matsumoto T, Motley ED, Utsunomiya H, Inagami T (1996) Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. J Biol Chem 271: 14169-14175.
38. Linseman DA, Benjamin CW, Jones DA (1995) Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells. J Biol Chem 270: 12563-12568.
39. Daub H, Weiss FU, Wallasch C, Ullrich A (1996) Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature 379: 557-560.
40. van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ (1995) Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signaling pathway. Nature 376: 781-784.
41. Berk BC, Corson MA (1997) Angiotensin II signal transduction in vascular smooth muscle-role of tyrosine kinases. Circ Res 80: 607-616.
42. Inagami T, Eguchi S, Tsuzuki S, Ichiki T (1997) Angiotensin II receptors AT1 and AT2 - New mechanism of signaling and antagonistic effects of AT1 and AT2. Jpn Circ J 61: 807-813.
43. Millan MA, Carvallo P, Izumi SI, Zemel S, Catt KJ, Aguilera G (1989) Novel sites of expression of functional angiotensin II receptors in the late gestation fetus. Science 244: 1340-1342.
44. Grady EF, Sechi LA, Griffin CA, Schambolan M, Kalinucle JE (1991) Expression of AT2 receptors in the developing rat fetus. J Clin Invest 88: 901-933.
45. Kambayashi Y, Bardhan S, Takahashi K, Tsuzuki S, Inui H, Hamakubo T, Inagami T (1993) Molecular cloning of a novel angiotensin II receptor isoform involved in phosphoryrosine phosphate inhibition. J Biol Chem 268: 24543-24546.
46. Mukoyama M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ (1993) Expression cloning of type 2 angiotensin II receptor reveals an unique class of seven-transmembrane receptors. J Biol Chem 268: 24539-24542.
47. Kizima K, Matsubara H, Murasawa S, Maruyama K, Ohkubo N, Mori Y, Inada M (1996) Regulation of angiotensin II type2 receptor gene by the protein kinase C-calcium pathway. Hypertension 27: 529-534.
48. Kizima K, Matsubara H, Murasawa S, Maruyama K, Mori Y, Inada M (1995) Gene transcription of angiotensin II type 2 receptor is repressed by growth factors and glucocorticoids in PC12 cells. Biochem Biophs Res Commun 216: 359-366.
49. Murasawa S, Matsubara H, Kijima K, Maruyama K, Ohkubo N, Mori Y, Iwasaka T, Inada M (1996) Down-regulation by cAMP of angiotensin II type 2 receptor gene expression in PC12 cells. Hypertens Res 19: 271-279.
50. Bottari SP, King IN, Reichlin S, Dahlstroem I, Lydon N, deGasparo M (1992) The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem Biophys Res Commun 183: 206-211.
51. Tsuzuki S, Eguchi S, Inagami T (1996) Inhibition of cell proliferation and activation of protein tyrosine phosphatase mediated by angiotensin II type 2 (AT2) receptor in R3T3 cells. Biochem Biophys Res Commun 228: 825-830.
52. Tsuzuki S, Matoba T, Eguchi S, Inagami T (1996) Angiotensin II type 2 receptor inhibits cell proliferation and activates tyrosine phosphatase. Hypertension 28: 916-918.
53. Geisterifer AA, Peach MJ, Owens GK (1988) Angiotensin II induces hypertrophy not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 62: 749-756.
54. ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J 15: 775-787.
55. Stoll M, Steckelings UM, Paul M, Bottari SP, Metzger R, Unger T (1995) The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 95: 651-657.
56. Nakajima M, Hutchinson HG, Fuginaga M, Hayashida W, Zhang L, Horiuchi M, Pratt RE, Dzau VJ (1995) The angiotensin II type 2 (AT2) antagonizes the growth effects of the AT1 receptor: Gain-of-function study using gene transfer. Proc Natl Acad Sci USA 82: 10663-10667.
57. Ohkubo N, Matsubara H, Nozawa Y, Mori Y, Murasawa S, Kijima K, Maruyama K, Masaki H, Iwasaka T, Inada M (1997) Angiotensin type 2 receptors are re-expressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation 96: 3954-3962.
58. Yamada T, Horiuchi M, Dzau VJ (1996) Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 93: 156-160.
59. Hayashida W, Horiuchi M, Dzau VJ (1996) Intracellular third loop domain of angiotensin II type-2 receptor: Role in mediating signal transduction and cellular function. J Biol Chem 271: 21985-21992.
60. Kang J, Sumners C, Posner P (1993) Angiotensin II type 2 receptor-modulated changes in potassium chrrents in cultured neurons. Am J Physiol 265: C607-C616.
61. + currents involves an inhibitory GTP binding protein. Am J Physiol 267: C1389-C1397.
62. Buisson B, Laflamme L, Bottari SP, de Gasparo M, Gallo-Payet N, Payel MD (1995) A G protein is involved in the angiotensin AT2 receptor inhibition of the T-type calcium current in non-differentiated NG 108-15 cells. J Biol Chem 270: 1670-1674.
63. 1α3 in the rat fetus. J Biol Chem 271: 15026-15033.
64. Matsubara H, Kanasaki M, Murasawa S, Tsukaguchi Y, Nio Y, Inada M (1994) Differential gene expression and regulation of angiotensin II receptor subtypes in rat cardiac fibroblasts and cardiomyocytes in culture. J Clin Invest 93: 1592-1601.
65. Kijima K., Matsubara H, Komuro I, Yazaki Y, Inada M (1996) Mechanical stretch induces enhanced expression of angiotensin II receptors in neonatal rat cardiac myocytes. Circ Res 79: 887-897.
66. Nio Y, Matsubara H, Murasawa S, Kanasaki M, Inada M (1995) Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest 95: 46-54.
67. Regitz-Zagrosek V, Friedel N, Heymann A, Bauer P, Neuß M, Rolfs A, Steffen C, Hildebrandt A, Hetzer R, Fleck E (1995) Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts. Circulation 91: 1461-1471.
68. Rogg H, de Gasparo M, Graedel E, Stulz P, Burkart F, Eberhard M, Erne P (1996) Angiotensin II-receptor subtypes in human atria and evidence for alterations in patients with cardiac dysfunction. Eur Heart J 17: 1112-1120.
69. Tsutsumi Y, Matsubara H, Mori Y, Murasawa S, Maruyama K, Masaki H, Iwasaka T, Inada M (1998) Expression, function and tissue distribution of angiotensin II AT1 and AT2 receptor subtypes in human failing heart. Cir Res (In press).
70. Douglas JG, Hopfer U (1995) Novel aspect of angiotensin receptors and signal transduction in the kidney. Annu Rev Physiol 56: 649-669.
71. Edwards RM, Stack EJ, Weidley EF, Aiyar N, Keehan RM, Hill DT, Weinstock J (1992) Characterization of renal angiotensin II receptors using subtype selective antagonists. J Pharmacol Exp Ther 260: 933-938.
72. Gauquelin G, Garcia R (1992) Characterization of glomerular angiotensin II receptor subtypes. Receptor 2: 207-212.
73. Gibson RE, Thorpe HH, Cartwright ME, Frank JD, Schorn TW, Bunting PB, Siegl PK (1991) Angiotensin receptor subtypes in renal cortex of rats and rhesus monkeys. Am J Physiol 261: F512-518.
74. Chang RS, Lotti VJ (1991) Angiotensin II receptor subtypes in rat, rabbit and monkey tissues: Relative distribution and species dependency. Life Sci 49: 1485-1490.
75. Sechi LA, Grady EF, Griffin CA, Kalinyak JE, Schambelan M (1992) Distribution of angiotensin II receptor subtypes in rat and human kidney. Am J Physiol 262: F236-240.
76. Jourdain M, Amiel C, Friedlander G (1992) Modulation of Na-H exchange activity by angiotensin II in opossum kidney cells. Am J Physiol 263: C1141-1146.
77. Grone HJ, Simon M, Fuchs E (1992) Autoradiographic characterization of angiotensin receptor subtypes in fetal and human kidney. Am J Physiol 262: F326-F331.
78. Goldfarb DA, Diz DI, Tubbs RR, Ferrario CM, Novick AC (1994) Angiotensin II recepter subtypes in the human renal cortex and renal cell carcinoma. J Urol 151: 208-213.
79. De leon H, Garcia R (1992) Angiotensin II receptor subtypes in rat renal preglomerular vessels. Receptor 2: 253-260.
80. Chansel D, Vandermeersch S, Pham P, Ardaollou R (1993) Characterization of [H3]losartan rceptors in isolated rat glomeruli. Eur J Pharmacol-Molec Pharm 247: 193-198.
81. Terada Y, Tomita K, Nonoguchi H, Marumo F (1993) PCR localization of angiotensin II receptor and angiotensinogen messenger RNAs in rat kidney. Kidney Int 43: 1251-1259.
82. Kakinuma Y, Fogo A, Inagami T, Ichikawa I (1993) Intrarenal localization of angiotensin II type 1 receptor messenger RNA in the rat. Kidney Int 43: 1229-1235.
83. Meister B, Lippoldt A, Bunnemann B, Inagami T, Ganten D, Fuxe K (1993) Cellular expression of angiotensin type-1 receptor messenger RNA in the kidney. Kidney Int 44: 331-336.
84. Paxton WG, Runge M, Horaist C, Cohen C, Alexander RW, Bernstein KE (1993) Immunohistochemical localization of rat angiotensin II AT1 receptor. Am J Physiol 264: F989-F995.
85. Kambayashi Y, Bardhas S, Takahashi K, Tsuzuki S, Inui H, Hamakubo T, Inagami T (1993) Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem 268: 24543-24546.
86. Herblin WF, Diamond SM, Timmermans PBMWM (1991) Localization of angiotensin II receptor subtypes in the rabbit adrenal and kidney. Peptides 12: 581-584.
87. Keiser JA, Bjork FA, Hodges JC, Tayor DG, Jr (1992) Renal hemodynamic and excretory response to PD123319 and losartan, nonpeptide AT1 and AT2 subtype-specific angiotensin II ligands. J Pharm Exp Ther 263: 1154-1160.
88. Lo M, Liu KL, Lanteime P, Sassard J (1995) Subtype 2 of angiotensin II receptors controls pressure natriuresis in rats. J Clin Invest 95: 1394-1397.
89. Hein L, Stevens ME, Barsh GS, Pratt RE, Kobilka BK, Dzau VJ (1997) Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc Natl Acad Sci USA 94: 6391-6396.
90. Christen Y, Waeber B, Nussberger J, Porchet RN, Timmermans PBMWM, Brunner HR (1991) Oral administration of Dup753 a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of presser response to exogenous angiotensin I and II. Circulation 83: 1333-1342.
91. Asano K, Dutcher DL, Port JD, Minobe WA, Trammel KD, Roden RL, Bohlmeyer TJ, Bush EW, Jenkin MJ, Abraham WT, Raynolds MV, Zisman LS, Perryman MB, Bristow MR (1997) Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium. Circulation 95: 1193-1200.
92. Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas I, Deedwania P, Ney DE, Snavely DB, Chang PI (1997) Randomized trial of losartan versus captoril in patients over 65 with heart failure (Evaluation of losartan in the Elderly Study, ELITE). Lancet 349: 747-752.
93. Matsubara H, Sugaya T, Mori Y, Murasawa S, Shibazaki Y, Tsutsumi Y, Moriguchi Y, Iwasaka T, Inada M (1998) Tissue-specific expression of human angiotensin II AT1 and AT2 receptors and cellular localization of subtype mRNAs in human renal cortex using in situ hybridization. Nephron (In press).
94. Masaki H, Matsubara H, Nozawa Y, Mori Y, Murasawa S, Kizima K, Maruyama K, Inada M (1998) Cardiac-specific Overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest 101: 527-535.