Angiotensin AT2 receptors directly stimulate renal nitric oxide in Bradykinin B2-receptor-null mice

Hypertension

Volumn 42, Issue 4 I, 2003, Pages 600-604

  Abadir, Peter M ^b   Carey, Robert M ^b   Siragy, Helmy M ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NONE

Author keywords

Angiotensin II; Animals, transgenic; Cyclic GMP; Nitric oxide; Receptors, angiotensin II; Receptors, bradykinin

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN I; ANGIOTENSIN RECEPTOR; BRADYKININ B2 RECEPTOR; CYCLIC GMP; NITRIC OXIDE; VALSARTAN; ANGIOTENSIN 1 RECEPTOR; BRADYKININ RECEPTOR; DRUG DERIVATIVE; IMIDAZOLE DERIVATIVE; NITRATE; NITRITE; PYRIDINE DERIVATIVE; SODIUM; TETRAZOLE DERIVATIVE; VALINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INTERSTITIAL FLUID; MICRODIALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; SODIUM INTAKE; TRANSGENIC ANIMAL; ANIMAL; BIOSYNTHESIS; BLOOD PRESSURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; EXTRACELLULAR SPACE; GENETICS; KIDNEY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; BLOOD PRESSURE; CYCLIC GMP; EXTRACELLULAR SPACE; IMIDAZOLES; KIDNEY; MICE; MICE, KNOCKOUT; NITRATES; NITRIC OXIDE; NITRITES; PYRIDINES; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTOR, BRADYKININ B2; RECEPTORS, ANGIOTENSIN; RECEPTORS, BRADYKININ; SODIUM; TETRAZOLES; VALINE;

EID: 0141997228     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000090323.58122.5C     Document Type: Article

References (26)

1. 2 production in conscious rats. J Clin Invest. 1996;97:1978-1982.
2. Siragy HM, de Gasparo M, Carey RM. Angiotensin type 2 receptor mediates valsartan-induced hypotension in conscious rats. Hypertension. 2000;35:1074-1077.
3. 2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest. 1997;100:264-269.
4. 2) angiotensin receptor. Proc Natl Acad Sci USA. 1999;96:6506-6510.
5. 2 receptor in a renal wrap hypertension model. Hypertension. 1999;33:1237-1242.
6. 2 and nitric oxide. Hypertension. 1997;29:757-762.
7. Campbell DJ. The kallikrein-kinin system in humans. Clin Exp Pharmacol Physiol. 2001;28:1060-1065.
8. 2 receptor knockout mice. Biochem Biophys Res Commun. 1996;224:625-630.
9. 2 receptors. Hypertension. 1997;29(pt 2):483-487.
10. 2 receptor. Hypertension. 2001;37:1473-1479.
11. 2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem. 1995;270:13706-13710.
12. 1Areceptor induces antinatriuresis in conscious rats. Hypertension. 1999;33(pt 2):504-510.
13. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by kinin-dependent mechanisms. Hypertension. 1998;31:349-355.
14. Tsutsumi Y, Matsubara H, Masaki H, Kurihara H, Murasawa S, Takai S, Miyazaki M, Nozawa Y, Ozono R, Nakagawa K, Miwa T, Kawada N, Mori Y, Shibasaki Y, Tanaka Y, Fujiyama S, Koyama Y, Fujiyama A, Takahashi H, Iwasaka T. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation J Clin Invest. 1999;104:925-935.
15. Siragy HM, Jaffa AA, Margolius HS, Carey RM. Renin-angiotensin system modulates renal bradykinin production. Am J Physiol. 1996;271: R1090-R1095.
16. 1 receptor antagonist. J Biol Chem. 2001;276: 39721-39726.
17. 1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature. 2000;407:94-98.
18. Carey RM, Howell NL, Jin XH, Siragy HM. Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats. Hypertension. 2001;38:1272-1277.
19. 1 receptor mediates inhibition of neointima formation in rat artery after balloon angioplasty. Hypertension. 2000;36:364-370.
20. deBlois D, Bouthillier J, Marceau F. Pulse exposure to protein synthesis inhibitors enhances vascular responses to des-Arg9-bradykinin: possible role of interleukin-1. Br J Pharmacol. 1991;103:1057-1066.
21. Bouthillier J, Deblois D, Marceau F. Studies on the induction of pharmacological responses to des-Arg9-bradykinin in vitro and in vivo. Br J Pharmacol. 1987;92:257-264.
22. 1 receptor-mediated relaxation in the isolated rabbit carotid artery. Eur J Pharmacol. 1993; 239:63-67.
23. 1 receptors. J Cell Physiol. 2002;193: 275-286.
24. Wirth K, Hock FJ, Albus U, Linz W, Alpermann HG, Anagnostopoulos H, Henke ST, Breipohl G, König W, Knolle J, Schölkens BA. HOE 140, a new potent and long acting bradykinin-antagonist: in vivo studies. Br J Pharmacol. 1991;102:774-777.
25. 1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness. Nat Med. 2001;7:1003-1009.
26. 2 kinin receptor gene knockout mice. Circ Res. 2001;88:1072-1079.