A nonpeptide angiotensin II type 2 receptor agonist does not attenuate postmyocardial infarction left ventricular remodeling in mice

Journal of Cardiovascular Pharmacology

Volumn 59, Issue 4, 2012, Pages 363-368

  Jehle, Alexander B ^a   Xu, Yaqin ^a   Dimaria, Joseph M ^a   French, Brent A ^a   Epstein, Frederick H ^a   Berr, Stuart S ^a   Roy, Rene J ^a   Kemp, Brandon A ^a   Carey, Robert M ^a   Kramer, Christopher M ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

angiotensin II; angiotensin receptors; magnetic resonance imaging; myocardial infarction; remodeling

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR AGONIST; CANDESARTAN; HORMONE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CONTROLLED STUDY; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART VENTRICLE REMODELING; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENZIMIDAZOLES; CORONARY OCCLUSION; DISEASE MODELS, ANIMAL; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RECEPTOR, ANGIOTENSIN, TYPE 2; TETRAZOLES; TIME FACTORS; VENTRICULAR REMODELING;

EID: 84859885811     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182444110     Document Type: Article

References (24)

1. Li H, Gao Y, Grobe JL, et al. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor. Am J Physiol Heart Circ Physiol. 2007;292:H727-H735.
2. Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003;349:1893-1906. (Pubitemid 37409706)
3. Yang Z, Bove CM, French BA, et al. Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction. Circulation. 2002;106:106-111. (Pubitemid 34747449)
4. Voros S, Yang Z, Bove CM, et al. The interaction between AT1 and AT2 receptors during postinfarction left ventricular remodeling. Am J Physiol Heart Circ Physiol. 2006;290:H1004-H1010.
5. Bove CM, Yang Z, Gilson WD, et al. Nitric oxide mediates benefits of angiotensin II type 2 receptor in post-infarct remodeling. Hypertension. 2004;43:680-685. (Pubitemid 38282447)
6. Isbell DC, Voros S, Yang Z, et al. Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling. Am J Physiol Heart Circ Physiol. 2007;293:H3372-H3378. (Pubitemid 350230878)
7. Macari D, Bottari S, Whitebread S, et al. Renal actions of the selective angiotensin AT2 receptor ligands CGP 42112B and PD 123319 in the sodium-depleted rat. Eur J Pharmacol. 1993;249:85-93. (Pubitemid 23326913)
8. Wan Y, Wallinder C, Plouffe B, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004;47:5995-6008.
9. Kaschina E, Grzesiak A, Li J, et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation. 2008;118:2523-2532.
10. Yang Z, Zingarelli B, Szabo C. The crucial role of endogenous interleukin- 10 production in myocardial ischemia-reperfusion injury. Circulation. 2001;101:1019-1026.
11. Xu Y, Huo Y, Toufektsian MC, et al. Activated platelets contribute importantly to myocardial reperfusion injury. Am J Physiol Heart Circ Physiol. 2006;290:H692-H699.
12. Berr SS, Roy RJ, French BA, et al. Black blood gradient echo cine magnetic resonance imaging of the mouse heart. Magn Reson Med. 2005;53:1074-1079. (Pubitemid 40627782)
13. Lange SA, Wolf B, Schober K, et al. Chronic angiotensin II receptor blockade induces cardioprotection during ischemia by increased PKC- [varepsilon] expression in the mouse heart. J Cardovasc Pharmacol. 2007:46-55. (Pubitemid 46184331)
14. Nagamatsu S, Kornhauser JM, Burant CF, et al. Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization. J Biol Chem. 1992;267:467-472.
15. Yang Z, Berr SS, Gilson WD, et al. Simultaneous evaluation of infarct size and cardiac function in intact mice by contrast-enhanced cardiac magnetic resonance imaging reveals contractile dysfunction in noninfarcted regions early after myocardial infarction. Circulation. 2004; 109:1161-1167. (Pubitemid 38332621)
16. Sadoshima J, Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts: critical role of the AT1 receptor subtype. Circ Res. 1993;73:413-423. (Pubitemid 23238726)
17. Stoll M, Steckelings UM, Paul M, et al. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest. 1995;95:651-657.
18. Matsubara H. Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res. 1998;83:1182-1191. (Pubitemid 29006033)
19. Nio Y, Matsubara H, Murasawa S, et al. Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest. 1995;95:46-54.
20. Kuizinga MC, Smits JFM, Arends JW, et al. AT2 receptor blockade reduces cardiac interstitial cell DNA synthesis and cardiac function after rat myocardial infarction. J Mol Cell Cardiol. 1998;30:425-434. (Pubitemid 28116322)
21. Chiu AT, Herblin WF, McCall DE, et al. Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989;165:196-203. (Pubitemid 20012475)
22. Speth RC, Kim KH. Discrimination of two angiotensin II receptor subtypes with a selective agonist analogue of angiotensin II, p-aminophenylalanine6 angiotensin II. Biochem Biophys Res Commun. 1990;169:997-1006. (Pubitemid 20220719)
23. Whitebread S, Mele M, Kamber B, et al. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989;163:284-291. (Pubitemid 19227303)
24. McCarthy CA, Vinh A, Callaway JK, et al. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke. 2009;40:1482-1489.