Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

Apoptosis

Volumn 20, Issue 2, 2015, Pages 250-261

  Ve, Thomas ^a   Williams, Simon J ^a   Kobe, Bostjan ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Innate immunity; Nod like receptor (NLR); Plant disease resistance protein; Toll like receptor; Toll interleukin 1 receptor resistance protein (TIR) domain

Indexed keywords

BACTERIAL PROTEIN; INTERLEUKIN 1 RECEPTOR; TOLL INTERLEUKIN 1 RECEPTOR RESISTANCE PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; HUMAN; NONHUMAN; PLANT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; INNATE IMMUNITY; MOLECULAR GENETICS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; HUMANS; IMMUNITY, INNATE; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84925465183     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-1064-2     Document Type: Article

References (80)

1. Gay NJ, Keith FJ (1991) Drosophila Toll and IL-1 receptor. Nature 351:355-356
2. Whitham S, Dinesh-Kumar SP, Choi D, Hehl R, Corr C, Baker B (1994) The product of the tobacco mosaic virus resistance gene N: similarity to Toll and the interleukin-1 receptor. Cell 78:1101-1115
3. O'Neill L (2000) The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence. Biochem Soc Trans 28:557-563
4. Spear AM, Loman NJ, Atkins HS, Pallen MJ (2009) Microbial TIR domains: not necessarily agents of subversion? Trends Microbiol 17:393-398
5. Burns K, Martinon F, Esslinger C et al (1998) MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem 273:12203-12209
6. Van der Biezen EA, Jones JD (1998) Plant disease-resistance proteins and the gene-for-gene concept. Trends Biochem Sci 23:454-456
7. Meyers BC, Morgante M, Michelmore RW (2002) TIR-X and TIR-NBS proteins: two new families related to disease resistance TIR-NBS-LRR proteins encoded in Arabidopsis and other plant genomes. Plant J 32:77-92
8. Ve T, Gay NJ, Mansell A, Kobe B, Kellie S (2012) Adaptors in Toll-like receptor signaling and their potential as therapeutic target. Curr Drug Target 13:1360-1374
9. Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117:3720-3732
10. Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373-384
11. Boraschi D, Tagliabue A (2013) The interleukin-1 receptor family. Semin Immunol 25:394-407
12. Kang JY, Lee JO (2011) Structural biology of the Toll-like receptor family. Annu Rev Biochem 80:917-941
13. O'Neill LA, Bowie AG (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7:353-364
14. Medzhitov R, Preston-Hurlburt P, Kopp E et al (1998) MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 2:253-258
15. Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A (1998) The human Toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 187:2097-2101
16. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115-122
17. Takeuchi O, Hoshino K, Akira S (2000) Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 165:5392-5396
18. Barton GM, Kagan JC, Medzhitov R (2006) Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 7:49-56
19. Fitzgerald KA, Palsson-McDermott EM, Bowie AG et al (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413:78-83
20. Horng T, Barton GM, Flavell RA, Medzhitov R (2002) The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420:329-333
21. Horng T, Barton GM, Medzhitov R (2001) TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2:835-841
22. Yamamoto M, Sato S, Hemmi H et al (2002) Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420:324-329
23. Bonham KS, Orzalli MH, Hayashi K et al (2014) A promiscuous lipid-binding protein diversifies the subcellular sites of Toll-like receptor signal transduction. Cell 156:705-716
24. Hoebe K, Du X, Georgel P et al (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424:743-748
25. Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T (2003) TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 4:161-167
26. Yamamoto M, Sato S, Hemmi H et al (2003) Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301:640-643
27. Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R (2008) TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 9:361-368
28. Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T (2003) TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem 278:49751-49762
29. Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J (2013) Sarm1-mediated axon degeneration requires both SAM and TIR interactions. J Neurosci 33:13569-13580
30. Osterloh JM, Yang J, Rooney TM et al (2012) dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science 337:481-484
31. Xu Y, Tao X, Shen B et al (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408:111-115
32. Li C, Zienkiewicz J, Hawiger J (2005) Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway. J Biol Chem 280:26152-26159
33. Slack JL, Schooley K, Bonnert TP et al (2000) Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. J Biol Chem 275:4670-4678
34. Alaidarous M, Ve T, Casey LW et al (2014) Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB. J Biol Chem 289:654-668
35. Bernoux M, Ve T, Williams S et al (2011) Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host Microbe 9:200-211
36. Gautam JK, Ashish ComeauLD, Krueger JK, Smith MF Jr (2006) Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling. J Biol Chem 281:30132-30142
37. Valkov E, Stamp A, Dimaio F et al (2011) Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci USA 108:14879-14884
38. Williams SJ, Sohn KH, Wan L et al (2014) Structural basis for assembly and function of a heterodimeric plant immune receptor. Science 344:299-303
39. Jang TH, Park HH (2014) Crystal structure of TIR domain of TLR6 reveals novel dimeric Interface of TIR-TIR interaction for Toll-like receptor signaling pathway. J Mol Biol 426:3305-3313
40. Khan JA, Brint EK, O'Neill LA, Tong L (2004) Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J Biol Chem 279:31664-31670
41. Nyman T, Stenmark P, Flodin S, Johansson I, Hammarstrom M, Nordlund P (2008) The crystal structure of the human Toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. J Biol Chem 283:11861-11865
42. Enokizono Y, Kumeta H, Funami K et al (2013) Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. Proc Natl Acad Sci USA 110:19908-19913
43. Lin Z, Lu J, Zhou W, Shen Y (2012) Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling. PLoS ONE 7:e34202
44. Ohnishi H, Tochio H, Kato Z et al (2009) Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci USA 106:10260-10265
45. Snyder GA, Cirl C, Jiang J et al (2013) Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proc Natl Acad Sci USA 110:6985-6990
46. Snyder GA, Deredge D, Waldhuber A et al (2014) Crystal structures of the Toll/interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J Biol Chem 289:669-679
47. Woo JR, Kim S, Shoelson SE, Park S (2013) X-ray crystallographic structure of TIR-domain from the human TIR-domain containing adaptor protein/MyD88 adaptor-like protein (TIRAP/MAL). Bull Korean Chem Soc 33:3091-3094
48. Dangl JL, Horvath DM, Staskawicz BJ (2013) Pivoting the plant immune system from dissection to deployment. Science 341:746-751
49. Jones JDG, Dangl JL (2006) The plant immune system. Nature 444:323-329
50. Krasileva KV, Dahlbeck D, Staskawicz BJ (2010) Activation of an Arabidopsis resistance protein is specified by the in planta association of its leucine-rich repeat domain with the cognate oomycete effector. Plant Cell 22:2444-2458
51. Swiderski MR, Birker D, Jones JD (2009) The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction. Mol Plant Microbe Interact 22:157-165
52. Caplan JL, Mamillapalli P, Burch-Smith TM, Czymmek K, Dinesh-Kumar SP (2008) Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector. Cell 132:449-462
53. Zhu Z, Xu F, Zhang Y et al (2010) Arabidopsis resistance protein SNC1 activates immune responses through association with a transcriptional corepressor. Proc Natl Acad Sci USA 107:13960-13965
54. Chan SL, Mukasa T, Santelli E, Low LY, Pascual J (2010) The crystal structure of a TIR domain from Arabidopsis thaliana reveals a conserved helical region unique to plants. Protein Sci 19:155-161
55. Zhang Q, Zmasek CM, Cai X, Godzik A (2011) TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog. Dev Comp Immunol 35:461-468
56. Cirl C, Wieser A, Yadav M et al (2008) Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins. Nat Med 14:399-406
57. Newman RM, Salunkhe P, Godzik A, Reed JC (2006) Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins. Infect Immun 74:594-601
58. Salcedo SP, Marchesini MI, Lelouard H et al (2008) Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1. PLoS Pathog 4:e21
59. Chan SL, Low LY, Hsu S et al (2009) Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain. J Biol Chem 284:21386-21392
60. Kaplan-Turkoz B, Koelblen T, Felix C et al (2013) Structure of the Toll/interleukin 1 receptor (TIR) domain of the immunosuppressive Brucella effector BtpA/Btp1/TcpB. FEBS Lett 587:3412-3416
61. Fekonja O, Bencina M, Jerala R (2012) Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling. J Biol Chem 287:30993-31002
62. Bovijn C, Ulrichts P, De Smet AS et al (2012) Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4. J Biol Chem 287:4088-4098
63. Nunez Miguel R, Wong J, Westoll JF et al (2007) A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS ONE 2:e788
64. Radhakrishnan GK, Yu Q, Harms JS, Splitter GA (2009) Brucella TIR domain-containing protein mimics properties of the Toll-like receptor adaptor protein TIRAP. J Biol Chem 284:9892-9898
65. Thomas C, Bazan JF, Garcia KC (2012) Structure of the activating IL-1 receptor signaling complex. Nat Struct Mol Biol 19:455-457
66. Wang D, Zhang S, Li L, Liu X, Mei K, Wang X (2010) Structural insights into the assembly and activation of IL-1beta with its receptors. Nat Immunol 11:905-911
67. Lin SC, Lo YC, Wu H (2010) Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 465:885-890
68. Ullah MO, Ve T, Mangan M et al (2013) The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins. Acta Crystallogr D Biol Crystallogr 69:2420-2430
69. Li J, McQuade T, Siemer AB et al (2012) The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150:339-350
70. Kobe B, Gleichmann T, Horne J, Jennings IG, Scotney PD, Teh T (1999) Turn up the HEAT. Structure 7:R91-R97
71. Stapleton D, Balan I, Pawson T, Sicheri F (1999) The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. Nat Struct Biol 6:44-49
72. Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y (2005) Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature 434:926-933
73. Kobe B, Kajava AV (2001) The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol 11:725-732
74. Deslandes L, Olivier J, Theulieres F et al (2002) Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes. Proc Natl Acad Sci USA 99:2404-2409
75. Finn RD, Bateman A, Clements J et al (2014) Pfam: the protein families database. Nucleic Acids Res 42:D222-D230
76. Gouet P, Robert X, Courcelle E (2003) ESPript/ENDscript: extracting and rendering sequence and 3D information from atomic structures of proteins. Nucleic Acids Res 31:3320-3323
77. Larkin MA, Blackshields G, Brown NP et al (2007) Clustal W and clustal X version 2.0. Bioinformatics 23:2947-2948
78. Roberts E, Eargle J, Wright D, Luthey-Schulten Z (2006) MultiSeq: unifying sequence and structure data for evolutionary analysis. BMC Bioinformatics 7:382
79. Humphrey W, Dalke A, Schulten K (1996) VMD: visual molecular dynamics. J Mol Graph 14(33-38):27-38
80. Tao X, Xu Y, Zheng Y, Beg AA, Tong L (2002) An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. Biochem Biophys Res Commun 299:216-221