Crystal structure of TIR domain of TLR6 reveals novel dimeric interface of TIR-TIR interaction for toll-like receptor signaling pathway

Journal of Molecular Biology

Volumn 426, Issue 19, 2014, Pages 3305-3313

  Jang, Tae Ho ^a   Park, Hyun Ho ^a  

^a Yeungnam University   (South Korea)

Author keywords

crystal structure; innate immunity; NF kappaB; TIR domain; TLR6

Indexed keywords

ADAPTOR PROTEIN; INTERLEUKIN 1 RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; MEMBRANE PROTEIN; TIRAP PROTEIN, HUMAN; TLR6 PROTEIN, HUMAN;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DIMERIZATION; DISULFIDE BOND; GEL FILTRATION CHROMATOGRAPHY; IMMUNE RESPONSE; INNATE IMMUNITY; MOLECULAR WEIGHT; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STOICHIOMETRY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENE VECTOR; GENETICS; HUMAN; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS);

AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GENE EXPRESSION; GENETIC VECTORS; HUMANS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 6;

EID: 84920184268     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.07.024     Document Type: Article

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