Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response

EMBO Molecular Medicine

Volumn 7, Issue 1, 2015, Pages 24-41

  Her, Zhisheng ^a,b   Teng, Terk Shin ^a   Tan, Jeslin J L ^a   Teo, Teck Hui ^a,c   Kam, Yiu Wing ^a   Lum, Fok Moon ^a,b   Lee, Wendy W L ^a,c   Gabriel, Christelle ^a,k   Melchiotti, Rossella ^a,d   Andiappan, Anand K ^a   Lulla, Valeria ^e   Lulla, Aleksei ^e   Win, Mar K ^f   Chow, Angela ^f   Biswas, Subhra K ^a   Leo, Yee Sin ^f   Lecuit, Marc ^g,h,i   Merits, Andres ^e   Rénia, Laurent ^a   Ng, Lisa F P ^a,b,j  

^a AGENCY FOR SCIENCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

^e UNIVERSITY OF TARTU   (Estonia)

^f TAN TOCK SENG HOSPITAL   (Singapore)

^g INSTITUT PASTEUR   (France)

^h INSERM   (France)

ⁱ UNIVERSITÉ PARIS DESCARTES   (France)

^j UNIVERSITY OF LIVERPOOL   (United Kingdom)

^k INSTITUT COCHIN   (France)

more..

Author keywords

Chikungunya virus; Innate immunity; Joint inflammation; Neutralizing antibodies; TLR3

Indexed keywords

GLYCOPROTEIN E2; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR 3; TLR3 PROTEIN, HUMAN; TLR3 PROTEIN, MOUSE; VIRUS ANTIBODY;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTHRITIS; ARTICLE; BONE MARROW CELL; CELL INFILTRATION; CHIKUNGUNYA; CHIKUNGUNYA ALPHAVIRUS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FIBROBLAST; GENOTYPE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; VIRAL CLEARANCE; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CHIKUNGUNYA VIRUS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SPECIES DIFFERENCE; VIROLOGY; YOUNG ADULT;

ADULT; AGED; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CHIKUNGUNYA FEVER; CHIKUNGUNYA VIRUS; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SPECIES SPECIFICITY; TOLL-LIKE RECEPTOR 3; VIRUS REPLICATION; YOUNG ADULT;

EID: 84925293102     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404459     Document Type: Article

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