Toll-like receptor 3 immune deficiency may be causative for HSV-2-associated Mollaret meningitis

European Neurology

Volumn 63, Issue 4, 2010, Pages 249-251

  Willmann, Olaf ^a   Ahmad Nejad, Parviz ^a   Neumaier, Michael ^a   Hennerici, Michael G ^a   Fatar, Marc ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; TOLL LIKE RECEPTOR 3; VALACICLOVIR;

ADULT; ASEPTIC MENINGITIS; CASE REPORT; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS 2; HUMAN; IMMUNE DEFICIENCY; IMMUNOASSAY; IMMUNOPATHOGENESIS; LETTER; LUMBAR PUNCTURE; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MONONUCLEAR CELL; NAUSEA; NECK INJURY; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTOALLERGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PYROSEQUENCING; VIRUS MENINGITIS; VOMITING; WESTERN BLOTTING;

ENZYME-LINKED IMMUNOSORBENT ASSAY; HERPES SIMPLEX; HERPESVIRUS 2, HUMAN; HUMANS; MALE; MENINGITIS; MIDDLE AGED; TOLL-LIKE RECEPTOR 3;

EID: 77950316957     PISSN: 00143022     EISSN: None     Source Type: Journal    
DOI: 10.1159/000287585     Document Type: Letter

References (14)

1. Zhang SY, Jouanguy E, Ugolini S, et al: TLR3 deficiency in patients with herpes simplex encephalitis. Science 2007; 317: 1522-1527.
2. Casrouge A, Zhang SY, Eidenschenk C, et al: Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 2006; 314: 308-312.
3. Ranjith-Kumar CT, Miller W, Sun J, et al: Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. J Biol Chem 2007; 282: 17697-17705.
4. Mollaret P: La méningite endothélioleucocytaire multirécurrente bénigne syndrome nouveau ou maladie nouvelle? Rev Neurol (Paris) 1944; 76: 57-67.
5. Shalabi M, Whitley RJ: Recurrent benign lymphocytic meningitis. Clin Infect Dis 2006; 43: 1194-1197.
6. Kupila L, Vainionpää R, Vuorinen T, Marttila RJ, Kotilainen P: Recurrent lymphocytic meningitis: the role of herpesviruses. Arch Neurol 2004; 61: 1553-1557.
7. Galdi AP: Benign recurrent aseptic meningitis (Mollaret's meningitis): case report and clinical review. Arch Neurol 1979; 36: 657-658.
8. Dylewski JS, Bekhor S: Mollaret's meningitis caused by herpes simplex virus type 2: case report and literature review. Eur J Clin Microbiol Infect Dis 2004; 23: 560-562.
9. Omland LH, Vestergaard BF, Wandall JH: Herpes simplex virus type 2 infections of the central nervous system: a retrospective study of 49 patients. Scand J Infect Dis 2008; 40: 59-62.
10. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA: Recognition of double-stranded RNA and activation of NF-kappaB by Tolllike receptor 3. Nature 2001; 413: 732-738.
11. Gill N, Davies EJ, Ashkar AA: The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection. Am J Reprod Immunol 2008; 59: 35-43.
12. Aurelius E, Forsgren M, Gille E, Sköldenberg B: Neurologic morbidity after herpes simplex virus type 2 meningitis: a retrospective study of 40 patients. Scand J Infect Dis 2002; 34: 278-283.
13. Tyler KL: Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret's. Herpes 2004; 11(suppl 2):57A-64A.
14. Wald A, Selke S, Warren T, Aoki FY, Sacks S, Diaz-Mitoma F, Corey L: Comparative efficacy of famciclovir and valacyclovir for suppression of recurrent genital herpes and viral shedding. Sex Transm Dis 2006; 33: 529-533.