Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor

Journal of Infectious Diseases

Volumn 203, Issue 2, 2011, Pages 149-157

  Chow, Angela ^a,c   Her, Zhisheng ^c,d   Ong, Edward K S ^d   Chen, Jin Miao ^d   Dimatatac, Frederico ^a   Kwek, Dyan J C ^d   Barkham, Timothy ^b   Yang, Henry ^d   Rénia, Laurent ^d   Leo, Yee Sin ^a   Ng, Lisa F P ^c,d  

^a NATIONAL CENTRE FOR INFECTIOUS DISEASES   (Singapore)

^b TAN TOCK SENG HOSPITAL   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; EOTAXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 17; INTERLEUKIN 6; SCATTER FACTOR;

ADULT; AGED; ARTHRALGIA; ARTICLE; CASE CONTROL STUDY; CHIKUNGUNYA; CHIKUNGUNYA ALPHAVIRUS; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; LONGITUDINAL STUDY; LYMPHOCYTOPENIA; MALE; MEDIATOR; MONOCYTE; NEUTROPHILIA; PRIORITY JOURNAL; VIREMIA; VIRUS LOAD;

ADULT; AGED; ALPHAVIRUS INFECTIONS; ARTHRALGIA; ARTHRITIS; BLOOD; CASE-CONTROL STUDIES; CHIKUNGUNYA VIRUS; CYTOKINES; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; VIRAL LOAD;

EID: 79851485115     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq042     Document Type: Article

References (40)

1. AbuBakar S, Sam IC, Wong PF, MatRahim N, Hooi PS, Roslan N. Reemergence of endemic Chikungunya, Malaysia. Emerg Infect Dis 2007; 13:147-9.
2. Beltrame A, Angheben A, Bisoffi Z, et al. Imported Chikungunya infection, Italy. Emerg Infect Dis 2007; 13:1264-6.
3. Bonn D. How did Chikungunya reach the Indian Ocean? Lancet Infect Dis 2006; 6:543.
4. Enserink M. Tropical disease follows mosquitoes to Europe. Science 2007; 317:1485. (Pubitemid 47417406)
5. Leelarasamee A, Chupaprawan C, Chenchittikul M, Udompanthurat S. Etiologies of acute undifferentiated febrile illness in Thailand. J Med Assoc Thai 2004; 87:464-72. (Pubitemid 38736182)
6. Leo YS, Chow AL, Tan LK, Lye DC, Lin L, Ng LC. Chikungunya outbreak, Singapore, 2008. Emerg Infect Dis 2009; 15:836-7.
7. Charrel RN, De Lamballerie X, Raoult D. Chikungunya outbreaks-the globalization of vectorborne diseases. N Engl J Med 2007; 356:769-71. (Pubitemid 46294608)
8. Pialoux G, Gauzere BA, Jaureguiberry S, Strobel M. Chikungunya, an epidemic arbovirosis. Lancet Infect Dis 2007; 7:319-27. (Pubitemid 46613868)
9. Powers AM, Logue CH. Changing patterns of Chikungunya virus: Re-emergence of a zoonotic arbovirus. J Gen Virol 2007; 88:2363-77.
10. Toivanen A. Alphaviruses: An emerging cause of arthritis? Curr Opin Rheumatol 2008; 20:486-90.
11. Taubitz W, Cramer JP, Kapaun A, et al. Chikungunya fever in travelers: Clinical presentation and course. Clin Infect Dis 2007; 45(1);e1-4.
12. Economopoulou A, Dominguez M, Helynck B, et al. Atypical Chikungunya virus infections: Clinical manifestations, mortality risk factors for severe disease during the 2005-2006 outbreak on Reunion. Epidemiol Infect 2009; 137(4);534-41.
13. Couderc T, Chrétien F, Schilte C, et al. A mouse model for Chikungunya: young age and inefficient Type I interferon signaling are risk factors for severe disease. PloS Pathog 2008; 4:e29.
14. Schilte C, Couderc T, Chretien F, et al. Type I IFN controls Chikungunya virus via its action on nonhematopoietic cells. J Exp Med 2010; 207:429-42.
15. Ziegler SA, Lu L, da Rosa AP, Xiao SY, Tesh RB. An animal model for studying the pathogenesis of Chikungunya virus infection. Am J Trop Med Hyg 2008; 79:133-9. (Pubitemid 351957217)
16. Ng LFP, Chow A, Sun YJ, et al. IL-1β, IL-6, RANTES as biomarkers of Chikungunya severity. PLoS One 2009; 4:e4261.
17. Panning M, Grywna K, van Esbroeck M, Emmerich P, Drosten C. Chikungunya fever in travelers returning to Europe from the Indian Ocean region, 2006. Emerg Infect Dis 2008; 14:416-22.
18. Parola P, De Lamballerie X, Jourdan J, et al. Novel Chikungunya virus variant in travelers returning from Indian Ocean islands. Emerg Infect Dis 2006; 12:1493-9. (Pubitemid 44574359)
19. Labadie K, Larcher T, Joubert C, et al. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest 2010; 120:894-906.
20. Win MK, Chow A, Dimatatac F, Go CJ, Leo YS. Chikungunya fever in Singapore: Acute clinical laboratory features, and factors associated with persistent arthralgia. J Clin Virol 2010; 49:111-4.
21. Coffey LL, Mertens E, Brehin AC, et al. Human genetic determinants of dengue virus susceptibility. Microbes Infect 2009; 11:143-56.
22. Tang J, Shelton B, Makhatadze NJ, et al. Distribution of chemokine receptor CCR2 CCR5 genotypes and their relative contribution to human immunodeficiency virus Type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression. J Virol 2002; 76(2);662-72.
23. Lokireddy S, Sarojamma V, Ramakrishna V. Genetic predisposition to Chikungunya - a blood group study in Chikungunya affected families. Virol J 2009; 6:77.
24. Her Z, Malleret B, Chan M, et al. Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response. J Immunol 2010; 184:5903-13.
25. Sourisseau M, Schilte C, Casartelli N, et al. Characterization of re-emerging Chikungunya virus. PloS Pathog 2007; 4:e89.
26. Aspinall R, Henson S, Pido-Lopez J, Ngom PT. Interleukin-7: An interleukin for rejuvenating the immune system. Ann N Y Acad Sci 2004; 1019:116-22. (Pubitemid 38951294)
27. Hoarau JJ, Bandjee MC, Trotot PK, et al. Persistent chronic inflammation infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response. J Immunol 2010; 184(10);5914-27.
28. Trinchieri G. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma). Curr Opin Immunol 1997; 9:17-23. (Pubitemid 27095894)
29. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A 1994; 91:3652-6.
30. Harvey CE, Post JJ, Palladinetti P, et al. Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity lobular inflammation. J Leukoc Biol 2003; 74(3);360-9.
31. Arnaud C, Burger F, Steffens S, et al. Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: New evidence for direct antiinflammatory effects of statins. Arterioscler Thromb Vasc Biol 2005; 25(6);1231-6.
32. Vaisman N, Leibovitz E, Dagan R, Barak V. The involvement of IL-6 IL-8 in acute invasive gastroenteritis of children. Cytokine 2003; 22(6);194-7.
33. Karadag F, Kirdar S, Karul AB, Ceylan E. The value of C-reactive protein as a marker of systemic inflammation in stable chronic obstructive pulmonary disease. Eur J Intern Med 2008; 19:104-8.
34. Xu HL, Ye X, Steinberg H, Liu SF. Selective blockade of endothelial NF-kappaB pathway differentially affects systemic inflammation multiple organ dysfunction and injury in septic mice. J Pathol 2010; 220(4);490-8.
35. Kennedy AC, Fleming J, Solomon L. Chikungunya viral arthropathy: A clinical description. J Rheumatol 1980; 7:231-6. (Pubitemid 11222940)
36. Borgherini G, Poubeau P, Staikowsky F, et al. Outbreak of Chikungunya on Reunion Island: Early clinical laboratory features in 157 adult patients. Clin Infect Dis 2007; 44(11);1401-7.
37. Staikowsky F, Talarmin F, Grivard P, et al. Prospective study of Chikungunya virus acute infection in the island of La Reunion during the 2005-2006 outbreak. LoS One 2009; 4(10);e7603.
38. Cornish AL, Campbell IK, McKenzie BS, Chatfield S, Wicks IP. G-CSF GM-CSF as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol 2009; 5(10);554-9.
39. Miossec P, Korn T, Kuchroo VK. Interleukin-17 type 17 helper T cells. N Engl J Med 2009; 361(9);888-98.
40. Hegab A, Kubo H, Yamaya M, et al. Intranasal HGF administration ameliorates the physiologic morphologic changes in lung emphysema. Mol Ther 2008; 16(8);1417-26.