Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Pohjala, Leena ^a,b   Utt, Age ^c   Varjak, Margus ^c   Lulla, Aleksei ^c   Merits, Andres ^c   Ahola, Tero ^a   Tammela, Päivi ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

10H PHENOTHIAZINYL; ACYLTRANSFERASE; APIGENIN; CHLORPROMAZINE; CHRYSIN; GLYCINE TRANSPORTER; LUCIFERASE; NARINGENIN; NONSTRUCTURAL PROTEIN 2; PHENOTHIAZINE DERIVATIVE; PUROMYCIN ACYLTRANSFERASE; SILIBININ; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; ANTIVIRUS AGENT; FLAVONOID; PHENOTHIAZINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN BHK; CHIKUNGUNYA ALPHAVIRUS; CONTROLLED STUDY; EGFP GENE; ENZYME ACTIVITY; ENZYME REPRESSION; GENE EXPRESSION; IC 50; MARKER GENE; NONHUMAN; NORTHERN BLOTTING; PHENOTYPE; RENILLA LUCIFERASE GENE; REPORTER GENE; RNA SYNTHESIS; SEMLIKI FOREST ALPHAVIRUS; TEMPERATURE SENSITIVE MUTANT; VIRUS CULTURE; VIRUS ENTRY; VIRUS INHIBITION; VIRUS REPLICATION; CELL LINE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; GENETICS; HUMAN; METHODOLOGY; PHYSIOLOGY; REPLICON;

ANTIVIRAL AGENTS; CELL LINE; CHIKUNGUNYA VIRUS; DRUG EVALUATION, PRECLINICAL; FLAVONOIDS; HUMANS; PHENOTHIAZINES; REPLICON; SEMLIKI FOREST VIRUS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 83655212354     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028923     Document Type: Article

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