Decreased dengue replication and an increased anti-viral humoral response with the use of combined toll-like receptor 3 and 7/8 agonists in macaques

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Sariol, Carlos A ^a,b,c   Martínez, Melween I ^a   Rivera, Francheska ^a   van Rodríguez, Idiaessa ^a   Pantoja, Petraleigh ^a   Abel, Kristina ^d   Arana, Teresa ^b   Giavedoni, Luis ^c   Hodara, Vida ^c   White, Laura J ^e   Angleró, Yesseinia I ^b   Montaner, Luis J ^f   Kraiselburd, Edmundo N ^a,b  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS   (Puerto Rico)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CLM 097M 012; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS ANTIBODY; CYTOKINE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIBODY TITER; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL ACTIVATION; CONTROLLED STUDY; DENGUE; DRUG EFFICACY; FLOW CYTOMETRY; HUMORAL IMMUNITY; IN VIVO STUDY; INFECTION CONTROL; INFLAMMATION; INNATE IMMUNITY; MYELOID DENDRITIC CELL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PROTECTION; PROTEIN BLOOD LEVEL; RECEPTOR UPREGULATION; RHESUS MONKEY; VIRUS INHIBITION; ANIMAL; CYTOLOGY; DENGUE VIRUS; DRUG POTENTIATION; FEMALE; GENETICS; IMMUNOLOGY; MACACA MULATTA; MALE; METABOLISM; MONONUCLEAR CELL; VIRUS REPLICATION;

DENGUE VIRUS; MACACA; MACACA MULATTA;

ANIMALS; CYTOKINES; DENGUE; DENGUE VIRUS; FEMALE; FLOW CYTOMETRY; IMMUNITY, INNATE; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; MACACA MULATTA; MALE; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; VIRUS REPLICATION;

EID: 79955784340     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019323     Document Type: Article

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