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Volumn 28, Issue 1, 2015, Pages 50-65

Toxicology and management of novel psychoactive drugs

Author keywords

cathinone; drug abuse; piperazine; synthetic cannabinoid; toxicity

Indexed keywords

CANNABINOID; CATHINONE; DESIGNER DRUG; ILLICIT DRUG; PIPERAZINE DERIVATIVE; PSYCHOTROPIC AGENT; ALKALOID; PIPERAZINE; STREET DRUG;

EID: 84924914120     PISSN: 08971900     EISSN: 15311937     Source Type: Journal    
DOI: 10.1177/0897190014544814     Document Type: Article
Times cited : (32)

References (154)
  • 1
    • 79960030672 scopus 로고    scopus 로고
    • College students and use of K2: an emerging drug of abuse in young persons
    • Hu X, Primack BA, Barnett TE, et al. College students and use of K2: an emerging drug of abuse in young persons. Subst Abuse Treat Prev Policy. 2011 ; 6: 16
    • (2011) Subst Abuse Treat Prev Policy , vol.6 , pp. 16
    • Hu, X.1    Primack, B.A.2    Barnett, T.E.3
  • 2
    • 79957635109 scopus 로고    scopus 로고
    • Emergency department visits after use of a drug sold as "bath salts" - Michigan, November 13, 2010-March 31, 2011
    • Emergency department visits after use of a drug sold as "bath salts" - Michigan, November 13, 2010-March 31, 2011. MMWR Morb Mortal Wkly Rep. 2011 ; 60 (19). 624-625
    • (2011) MMWR Morb Mortal Wkly Rep , vol.60 , Issue.19 , pp. 624-625
  • 3
    • 84878541676 scopus 로고    scopus 로고
    • American Association of Poison Control Centers. Accessed November 30, 2013
    • Synthetic Marijuana Data: October 31, 2013. American Association of Poison Control Centers. http://www.aapcc.org/alerts/synthetic-marijuana/. Accessed November 30, 2013.
    • Synthetic Marijuana Data: October 31, 2013
  • 6
    • 79952653377 scopus 로고    scopus 로고
    • The "new" marijuana
    • Wells DL, Ott CA. The "new" marijuana. Ann Pharmacother. 2011 ; 45 (3). 414-417
    • (2011) Ann Pharmacother , vol.45 , Issue.3 , pp. 414-417
    • Wells, D.L.1    Ott, C.A.2
  • 7
    • 77954954841 scopus 로고    scopus 로고
    • Spice drugs as a new trend: mode of action, identification and legislation
    • Vardakou I, Pistos C, Spiliopoulou C. Spice drugs as a new trend: mode of action, identification and legislation. Toxicol Lett. 2010 ; 197 (3). 157-162
    • (2010) Toxicol Lett , vol.197 , Issue.3 , pp. 157-162
    • Vardakou, I.1    Pistos, C.2    Spiliopoulou, C.3
  • 8
    • 84155164719 scopus 로고    scopus 로고
    • A survey study to characterize use of spice products (synthetic cannabinoids)
    • Vandrey R, Dunn KE, Fry JA, et al. A survey study to characterize use of spice products (synthetic cannabinoids). Drug Alcohol Depend. 2012 ; 120 (1-3). 238-241
    • (2012) Drug Alcohol Depend , vol.120 , Issue.13 , pp. 238-241
    • Vandrey, R.1    Dunn, K.E.2    Fry, J.A.3
  • 9
    • 84873157996 scopus 로고    scopus 로고
    • Synthetic cannabinoid intoxication: a case series and review
    • Harris CR, Brown A. Synthetic cannabinoid intoxication: a case series and review. J Emerg Med. 2012 ; 44 (2). 360-366
    • (2012) J Emerg Med , vol.44 , Issue.2 , pp. 360-366
    • Harris, C.R.1    Brown, A.2
  • 12
    • 77952291222 scopus 로고    scopus 로고
    • Chemical analysis of synthetic cannabinoids as designer drugs in herbal products
    • Uchiyama N, Kikura-Hanajiri R, Ogata J, et al. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Sci Int. 2010 ; 198 (1-3). 31-38
    • (2010) Forensic Sci Int , vol.198 , Issue.13 , pp. 31-38
    • Uchiyama, N.1    Kikura-Hanajiri, R.2    Ogata, J.3
  • 13
    • 67649159427 scopus 로고    scopus 로고
    • Investigating a not-so-natural high
    • Piggee C. Investigating a not-so-natural high. Anal Chem. 2009 ; 81 (9). 3205-3207
    • (2009) Anal Chem , vol.81 , Issue.9 , pp. 3205-3207
    • Piggee, C.1
  • 14
    • 77954890552 scopus 로고    scopus 로고
    • Psychoactive drug or mystical incense? Overview of the online available information on Spice products
    • Schifano F, Corazza O, Deluca P, et al. Psychoactive drug or mystical incense? Overview of the online available information on Spice products. Int J Cult Ment Health. 2009 ; 2: 137-144
    • (2009) Int J Cult Ment Health , vol.2 , pp. 137-144
    • Schifano, F.1    Corazza, O.2    Deluca, P.3
  • 15
    • 84862768861 scopus 로고    scopus 로고
    • Spice and K2 herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans
    • Gunderson EW, Haughey HM, Ait-Daoud N, et al. Spice and K2 herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans. Am J Addict. 2012 ; 21 (4). 320-326
    • (2012) Am J Addict , vol.21 , Issue.4 , pp. 320-326
    • Gunderson, E.W.1    Haughey, H.M.2    Ait-Daoud, N.3
  • 16
    • 84874936416 scopus 로고    scopus 로고
    • Patterns of synthetic cannabinoid use in Australia
    • Barratt MJ, Cakic V, Lenton S. Patterns of synthetic cannabinoid use in Australia. Drug Alcohol Rev. 2013 ; 32 (2). 141-146
    • (2013) Drug Alcohol Rev , vol.32 , Issue.2 , pp. 141-146
    • Barratt, M.J.1    Cakic, V.2    Lenton, S.3
  • 17
    • 84855756474 scopus 로고    scopus 로고
    • Synthetic cannabinoid exposures reported to Texas poison centers
    • Forrester MB, Kleinschmidt K, Schwarz E, et al. Synthetic cannabinoid exposures reported to Texas poison centers. J Addict Dis. 2011 ; 30 (10). 351-358
    • (2011) J Addict Dis , vol.30 , Issue.10 , pp. 351-358
    • Forrester, M.B.1    Kleinschmidt, K.2    Schwarz, E.3
  • 18
    • 38349158960 scopus 로고    scopus 로고
    • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
    • Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. Br J Pharmacol. 2008 ; 153 (2). 199-215
    • (2008) Br J Pharmacol , vol.153 , Issue.2 , pp. 199-215
    • Pertwee, R.G.1
  • 19
    • 33144480327 scopus 로고    scopus 로고
    • Cannabinoid receptors as therapeutic targets
    • Mackie K. Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol. 2006 ; 46: 101-122
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 101-122
    • Mackie, K.1
  • 20
    • 84872156419 scopus 로고    scopus 로고
    • The endocannabinoid system and the brain
    • Mechoulam R, Parker LA. The endocannabinoid system and the brain. Annu Rev Psychol. 2013 ; 64: 21-47
    • (2013) Annu Rev Psychol , vol.64 , pp. 21-47
    • Mechoulam, R.1    Parker, L.A.2
  • 21
    • 77952664328 scopus 로고    scopus 로고
    • JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist
    • Atwood BK, Huffman J, Straiker A, et al. JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist. Br J Pharmacol. 2010 ; 160 (3). 585-593
    • (2010) Br J Pharmacol , vol.160 , Issue.3 , pp. 585-593
    • Atwood, B.K.1    Huffman, J.2    Straiker, A.3
  • 22
    • 79955928510 scopus 로고    scopus 로고
    • CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB1 cannabinoid receptor agonists
    • Atwood BK, Lee D, Straiker A, et al. CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB1 cannabinoid receptor agonists. Eur J Pharmacol. 2011 ; 659 (2-3). 139-145
    • (2011) Eur J Pharmacol , vol.659 , Issue.23 , pp. 139-145
    • Atwood, B.K.1    Lee, D.2    Straiker, A.3
  • 23
    • 84894041500 scopus 로고    scopus 로고
    • Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: mechanism underlying greater toxicity
    • Fantegrossi WE, Moran JH, Radominska-Pandya A, et al. Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: mechanism underlying greater toxicity. Life Sci. 2014 ; 97 (1). 45-54
    • (2014) Life Sci , vol.97 , Issue.1 , pp. 45-54
    • Fantegrossi, W.E.1    Moran, J.H.2    Radominska-Pandya, A.3
  • 24
    • 84876424034 scopus 로고    scopus 로고
    • Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors
    • Rajasekaran M, Brents LK, Franks LN, et al. Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. Toxicol Appl Pharmacol. 2013 ; 269 (2). 100-108
    • (2013) Toxicol Appl Pharmacol , vol.269 , Issue.2 , pp. 100-108
    • Rajasekaran, M.1    Brents, L.K.2    Franks, L.N.3
  • 25
    • 66249133962 scopus 로고    scopus 로고
    • 'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs?
    • Auwarter V, Dresen S, Weinmann W, et al. 'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs?. J Mass Spectrom. 2009 ; 44 (5). 832-837
    • (2009) J Mass Spectrom , vol.44 , Issue.5 , pp. 832-837
    • Auwarter, V.1    Dresen, S.2    Weinmann, W.3
  • 26
    • 84865459635 scopus 로고    scopus 로고
    • Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation
    • 1320
    • Young AC, Medina G, Obafemi A, et al. Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation. Am J Emerg Med. 2012 1320 ; 30 (7). e5 - e7
    • (2012) Am J Emerg Med , vol.30 , Issue.7 , pp. e5-e7
    • Young, A.C.1    Medina, G.2    Obafemi, A.3
  • 27
    • 79960313022 scopus 로고    scopus 로고
    • Synthetic cannabinoid JWH-018 and psychosis: an explorative study
    • Every-Palmer S. Synthetic cannabinoid JWH-018 and psychosis: an explorative study. Drug Alcohol Depend. 2011 ; 117 (2-3). 152-157
    • (2011) Drug Alcohol Depend , vol.117 , Issue.23 , pp. 152-157
    • Every-Palmer, S.1
  • 29
    • 33748187632 scopus 로고    scopus 로고
    • Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine and codeine
    • Maurer HH, Sauer C, Theobald DS. Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine and codeine. Ther Drug Monit. 2006 ; 28 (3). 447-453
    • (2006) Ther Drug Monit , vol.28 , Issue.3 , pp. 447-453
    • Maurer, H.H.1    Sauer, C.2    Theobald, D.S.3
  • 30
    • 84867684839 scopus 로고    scopus 로고
    • Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands
    • Chimalakonda KC, Seely KA, Bratton SM, et al. Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands. Drug Metab Dispo. 2012 ; 40 (11). 2174-2184
    • (2012) Drug Metab Dispo , vol.40 , Issue.11 , pp. 2174-2184
    • Chimalakonda, K.C.1    Seely, K.A.2    Bratton, S.M.3
  • 31
    • 80053166693 scopus 로고    scopus 로고
    • Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases
    • Chimalakonda KC, Bratton SM, Le VH, et al. Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases. Drug Metab Dispos. 2011 ; 39 (10). 1967-1976
    • (2011) Drug Metab Dispos , vol.39 , Issue.10 , pp. 1967-1976
    • Chimalakonda, K.C.1    Bratton, S.M.2    Le, V.H.3
  • 32
    • 84882433884 scopus 로고    scopus 로고
    • Differential drug-drug interactions of the synthetic cannabinoids JWH-018 and JWH-073: Implications for drug abuse liability and pain therapy
    • Brents LK, Zimmerman SM, Saffell AR, et al. Differential drug-drug interactions of the synthetic cannabinoids JWH-018 and JWH-073: Implications for drug abuse liability and pain therapy. J Pharmacol Exp Ther. 2013 ; 346 (3). 350-361
    • (2013) J Pharmacol Exp Ther , vol.346 , Issue.3 , pp. 350-361
    • Brents, L.K.1    Zimmerman, S.M.2    Saffell, A.R.3
  • 33
    • 79953228493 scopus 로고    scopus 로고
    • Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?
    • Seely KA, Prather PL, James LP, et al. Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?. Mol Interv. 2011 ; 11 (1). 36-51
    • (2011) Mol Interv , vol.11 , Issue.1 , pp. 36-51
    • Seely, K.A.1    Prather, P.L.2    James, L.P.3
  • 34
    • 84892590817 scopus 로고    scopus 로고
    • European Monitoring Centre for Drugs and Drug Addiction. Accessed December 21, 2013
    • Perspectives on drugs: synthetic cannabinoids in Europe. European Monitoring Centre for Drugs and Drug Addiction; 2013. http://www.emcdda.europa.eu/topics/pods/synthetic-cannabinoids. Accessed December 21, 2013.
    • (2013) Perspectives on drugs: synthetic cannabinoids in Europe
  • 35
    • 78650752280 scopus 로고    scopus 로고
    • Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds
    • Dresen S, Ferreiros N, Putz M, et al. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J Mass Spectrom. 2010 ; 45 (10). 1186-1194
    • (2010) J Mass Spectrom , vol.45 , Issue.10 , pp. 1186-1194
    • Dresen, S.1    Ferreiros, N.2    Putz, M.3
  • 36
    • 84881225471 scopus 로고    scopus 로고
    • Spicing things up: synthetic cannabinoids
    • Spaderna M, Addy PH, D'Souza DC. Spicing things up: synthetic cannabinoids. Psychopharmacol. 2013 ; 228 (4). 525-540
    • (2013) Psychopharmacol , vol.228 , Issue.4 , pp. 525-540
    • Spaderna, M.1    Addy, P.H.2    D'Souza, D.C.3
  • 37
    • 84871534813 scopus 로고    scopus 로고
    • Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment
    • Englund A, Morrison PD, Nottage J, et al. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol. 2013 ; 27 (1). 19-27
    • (2013) J Psychopharmacol , vol.27 , Issue.1 , pp. 19-27
    • Englund, A.1    Morrison, P.D.2    Nottage, J.3
  • 38
    • 84890319601 scopus 로고    scopus 로고
    • Notes from the field: Severe illness associated with reported use of synthetic marijuana - Colorado August-September 2013
    • Notes from the field: Severe illness associated with reported use of synthetic marijuana - Colorado August-September 2013. MMWR Morb Mortal Wkly Rep. 2013 ; 62 (49). 1016-1017
    • (2013) MMWR Morb Mortal Wkly Rep , vol.62 , Issue.49 , pp. 1016-1017
  • 39
    • 84891848912 scopus 로고    scopus 로고
    • Notes from the field: severe illness associated synthetic cannabinoid use - Brunswick, Georgia, 2013
    • Notes from the field: severe illness associated synthetic cannabinoid use - Brunswick, Georgia, 2013. MMWR Morb Mortal Wkly Rep. 2013 ; 62 (46). 939
    • (2013) MMWR Morb Mortal Wkly Rep , vol.62 , Issue.46 , pp. 939
  • 40
    • 84866742397 scopus 로고    scopus 로고
    • A characterization of synthetic cannabinoid exposures reported to the National Poison Data System in 2010
    • Hoyte CO, Jacob J, Monte AA, et al. A characterization of synthetic cannabinoid exposures reported to the National Poison Data System in 2010. Ann Emerg Med. 2012 ; 60 (4). 435-438
    • (2012) Ann Emerg Med , vol.60 , Issue.4 , pp. 435-438
    • Hoyte, C.O.1    Jacob, J.2    Monte, A.A.3
  • 41
    • 80054812520 scopus 로고    scopus 로고
    • Psychosis associated with synthetic cannabinoid agonists: a case series
    • Hurst D, Loeffler G, McLay R. Psychosis associated with synthetic cannabinoid agonists: a case series. Am J Psychiatry. 2011 ; 168 (10). 1119
    • (2011) Am J Psychiatry , vol.168 , Issue.10 , pp. 1119
    • Hurst, D.1    Loeffler, G.2    McLay, R.3
  • 42
    • 80053020632 scopus 로고    scopus 로고
    • Synthetic cannabinoid use: a case series of adolescents
    • Castellanos D, Singh S, Thornton G, et al. Synthetic cannabinoid use: a case series of adolescents. J Adolesc Heal. 2011 ; 49 (4). 347-349
    • (2011) J Adolesc Heal , vol.49 , Issue.4 , pp. 347-349
    • Castellanos, D.1    Singh, S.2    Thornton, G.3
  • 43
    • 84857796142 scopus 로고    scopus 로고
    • Convulsion associated with the use of a synthetic cannabinoid product
    • Schneir AB, Baumbacher T. Convulsion associated with the use of a synthetic cannabinoid product. J Med Toxicol. 2012 ; 8 (1). 62-64
    • (2012) J Med Toxicol , vol.8 , Issue.1 , pp. 62-64
    • Schneir, A.B.1    Baumbacher, T.2
  • 45
    • 80053638478 scopus 로고    scopus 로고
    • Severe toxicity following synthetic cannabinoid ingestion
    • Lapoint J, James LP, Moran CL, et al. Severe toxicity following synthetic cannabinoid ingestion. Clin Toxicol. 2011 ; 49 (8). 760-764
    • (2011) Clin Toxicol , vol.49 , Issue.8 , pp. 760-764
    • Lapoint, J.1    James, L.P.2    Moran, C.L.3
  • 46
    • 84892176690 scopus 로고    scopus 로고
    • Ischemic stroke after use of the synthetic marijuana "spice"
    • Freeman MJ, Rose DZ, Myers MA, et al. Ischemic stroke after use of the synthetic marijuana "spice". Neurology. 2013 ; 81 (24). 2090-2093
    • (2013) Neurology , vol.81 , Issue.24 , pp. 2090-2093
    • Freeman, M.J.1    Rose, D.Z.2    Myers, M.A.3
  • 47
    • 84924900940 scopus 로고    scopus 로고
    • Ischemic stroke in a 28-year-old woman after smoking synthetic THC
    • Korya D, Kapoor A, Labiner D. Ischemic stroke in a 28-year-old woman after smoking synthetic THC. Neurology. 2013 ; 80:
    • (2013) Neurology , vol.80
    • Korya, D.1    Kapoor, A.2    Labiner, D.3
  • 48
    • 83255192504 scopus 로고    scopus 로고
    • Myocardial infarction associated with use of the synthetic cannabinoid K2
    • Mir A, Obafemi A, Young A, et al. Myocardial infarction associated with use of the synthetic cannabinoid K2. Pediatrics. 2011 ; 128 (6). 1622-1627
    • (2011) Pediatrics , vol.128 , Issue.6 , pp. 1622-1627
    • Mir, A.1    Obafemi, A.2    Young, A.3
  • 49
    • 84884675056 scopus 로고    scopus 로고
    • A case of cannabinoid hyperemesis syndrome caused by synthetic cannabinoids
    • Hopkins CY, Gilchrist BL. A case of cannabinoid hyperemesis syndrome caused by synthetic cannabinoids. J Emerg Med. 2013 ; 45 (4). 544-546
    • (2013) J Emerg Med , vol.45 , Issue.4 , pp. 544-546
    • Hopkins, C.Y.1    Gilchrist, B.L.2
  • 50
    • 79960219720 scopus 로고    scopus 로고
    • Three cases of "Spice" exposure
    • Simmons J, Cookman L, Kang C, et al. Three cases of "Spice" exposure. Clin Toxicol. 2011 ; 49 (5). 431-433
    • (2011) Clin Toxicol , vol.49 , Issue.5 , pp. 431-433
    • Simmons, J.1    Cookman, L.2    Kang, C.3
  • 52
    • 84874332101 scopus 로고    scopus 로고
    • Acute kidney injury associated with synthetic cannabinoid use - multiple states, 2012
    • Acute kidney injury associated with synthetic cannabinoid use - multiple states, 2012. MMWR Morb Mortal Wkly Rep. 2013 ; 62 (6). 93-98
    • (2013) MMWR Morb Mortal Wkly Rep , vol.62 , Issue.6 , pp. 93-98
  • 53
    • 84876061412 scopus 로고    scopus 로고
    • AKI associated with synthetic cannabinoids: a case series
    • Bhanushali GK, Jain G, Fatima H, et al. AKI associated with synthetic cannabinoids: a case series. Clin J Am Soc Nephrol. 2013 ; 8 (4). 1-4
    • (2013) Clin J Am Soc Nephrol , vol.8 , Issue.4 , pp. 1-4
    • Bhanushali, G.K.1    Jain, G.2    Fatima, H.3
  • 54
    • 84862167879 scopus 로고    scopus 로고
    • Detection of JWH-018 and JWH-073 by UPLC-MS-MS in postmortem whole blood casework
    • Shanks KG, Dahn T, Terrell AR. Detection of JWH-018 and JWH-073 by UPLC-MS-MS in postmortem whole blood casework. J Anal Toxicol. 2012 ; 36 (3). 145-152
    • (2012) J Anal Toxicol , vol.36 , Issue.3 , pp. 145-152
    • Shanks, K.G.1    Dahn, T.2    Terrell, A.R.3
  • 55
    • 84888867913 scopus 로고    scopus 로고
    • Toxicological findings of synthetic cannabinoids in recreational users
    • Kronstrand R, Roman M, Andersson M, et al. Toxicological findings of synthetic cannabinoids in recreational users. J Anal Toxicol. 2013 ; 37 (8). 534-541
    • (2013) J Anal Toxicol , vol.37 , Issue.8 , pp. 534-541
    • Kronstrand, R.1    Roman, M.2    Andersson, M.3
  • 56
    • 84886749049 scopus 로고    scopus 로고
    • K2 toxicity: fatal case of psychiatric complications following AM2201 exposure
    • Patton AL, Chimalakonda KC, Moran CL, et al. K2 toxicity: fatal case of psychiatric complications following AM2201 exposure. J Forensic Sci. 2013 ; 58 (6). 1676-1680
    • (2013) J Forensic Sci , vol.58 , Issue.6 , pp. 1676-1680
    • Patton, A.L.1    Chimalakonda, K.C.2    Moran, C.L.3
  • 57
    • 84873547512 scopus 로고    scopus 로고
    • Suicidal ideation and self-harm following K2 use
    • Thomas S, Bliss S, Malik M. Suicidal ideation and self-harm following K2 use. J Okla State Med Assoc. 2012 ; 105 (11). 430-433
    • (2012) J Okla State Med Assoc , vol.105 , Issue.11 , pp. 430-433
    • Thomas, S.1    Bliss, S.2    Malik, M.3
  • 58
    • 84886774491 scopus 로고    scopus 로고
    • Effects of acute detoxification of the herbal blend 'Spice Gold' on dopamine D2/3 receptor availability: A [18F]fallypride PET study
    • Rominger A, Cumming P, Xiong G, et al. Effects of acute detoxification of the herbal blend 'Spice Gold' on dopamine D2/3 receptor availability: A [18F]fallypride PET study. Eur Neuropsychopharmacol. 2013 ; 23 (11). 1606-1610
    • (2013) Eur Neuropsychopharmacol , vol.23 , Issue.11 , pp. 1606-1610
    • Rominger, A.1    Cumming, P.2    Xiong, G.3
  • 59
    • 84876940425 scopus 로고    scopus 로고
    • Acute intoxication caused by a synthetic cannabinoid in two adolescents
    • Heath TS, Burroughs Z, Thompson AJ, et al. Acute intoxication caused by a synthetic cannabinoid in two adolescents. J Pediatr Pharmacol Ther. 2012 ; 17 (2). 177-181
    • (2012) J Pediatr Pharmacol Ther , vol.17 , Issue.2 , pp. 177-181
    • Heath, T.S.1    Burroughs, Z.2    Thompson, A.J.3
  • 60
    • 84873974367 scopus 로고    scopus 로고
    • Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings
    • Hermanns-Clausen M, Kneisel S, Szabo B, et al. Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings. Addiction. 2013 ; 108 (3). 534-544
    • (2013) Addiction , vol.108 , Issue.3 , pp. 534-544
    • Hermanns-Clausen, M.1    Kneisel, S.2    Szabo, B.3
  • 61
    • 84859734926 scopus 로고    scopus 로고
    • Spice: a new "legal" herbal mixture abused by young active duty military personnel
    • Bebarta VS, Ramirez S, Varney SM. Spice: a new "legal" herbal mixture abused by young active duty military personnel. Subst Abuse. 2012 ; 33 (2). 191-194
    • (2012) Subst Abuse , vol.33 , Issue.2 , pp. 191-194
    • Bebarta, V.S.1    Ramirez, S.2    Varney, S.M.3
  • 62
    • 84893256882 scopus 로고
    • Washington, DC: US Government Printing Office
    • Treatment of Controlled Substance Analogues. Washington, DC: US Government Printing Office ; 1986: 452.
    • (1986) Treatment of Controlled Substance Analogues , pp. 452
  • 64
    • 84924914550 scopus 로고    scopus 로고
    • [Online]. Washington, DC: US Government Printing Office; Accessed December 9, 2013
    • Controlled Substances Act [Online]. Washington, DC: US Government Printing Office; 2012 579-584. http://www.gpo.gov/fdsys/pkg/USCODE-2012-title21/pdf/USCODE-2012-title21-chap13-subchapI-partB-sec812.pdf. Accessed December 9, 2013.
    • (2012) Controlled Substances Act , pp. 579-584
  • 65
    • 84878890238 scopus 로고    scopus 로고
    • Designer cathinones - an emerging class of novel recreational drugs
    • Zawilska JB, Wojcieszak J. Designer cathinones - an emerging class of novel recreational drugs. Forensic Sci Int. 2013 ; 231 (1-3). 42-53
    • (2013) Forensic Sci Int , vol.231 , Issue.13 , pp. 42-53
    • Zawilska, J.B.1    Wojcieszak, J.2
  • 66
    • 84872488954 scopus 로고    scopus 로고
    • 'Legal highs' an inappropriate term for 'novel psychoactive drugs' in drug prevention and scientific debate
    • Corazza O, Demetrovics W, van den Brink W, et al. 'Legal highs' an inappropriate term for 'novel psychoactive drugs' in drug prevention and scientific debate. Int J Drug Policy. 2013 ; 24 (1). 82-83
    • (2013) Int J Drug Policy , vol.24 , Issue.1 , pp. 82-83
    • Corazza, O.1    Demetrovics, W.2    Van Den Brink, W.3
  • 67
    • 84859628524 scopus 로고    scopus 로고
    • Synthetic cathinones: chemistry, pharmacology and toxicology of a new class of designer drugs of abuse marketed as "bath salts" or "plant food"
    • Coppola M, Mondola R. Synthetic cathinones: chemistry, pharmacology and toxicology of a new class of designer drugs of abuse marketed as "bath salts" or "plant food". Toxicol Lett. 2012 ; 211 (2). 144-149
    • (2012) Toxicol Lett , vol.211 , Issue.2 , pp. 144-149
    • Coppola, M.1    Mondola, R.2
  • 68
    • 84882819121 scopus 로고    scopus 로고
    • A 9-state analysis of designer stimulant, "Bath Salt," hospital visits reported to Poison Control Centers
    • Warrick BJ, Hill M, Hekman K, et al. A 9-state analysis of designer stimulant, "Bath Salt," hospital visits reported to Poison Control Centers. Ann Emerg Med. 2013 ; 62 (3). 244-251
    • (2013) Ann Emerg Med , vol.62 , Issue.3 , pp. 244-251
    • Warrick, B.J.1    Hill, M.2    Hekman, K.3
  • 69
    • 79951508689 scopus 로고    scopus 로고
    • Accessed January 2, 2014
    • Advisory council on the misuse of drugs. Consideration of the cathinones. https://www.gov.uk/government/uploads/system/uploads/attachment-data/file/119173/acmd-cathinodes-report-2010.pdf. Accessed January 2, 2014.
    • Consideration of the cathinones
  • 70
    • 84857800731 scopus 로고    scopus 로고
    • The toxicology of bath salts: a review of synthetic cathinones
    • Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol. 2012 ; 8 (1). 33-42
    • (2012) J Med Toxicol , vol.8 , Issue.1 , pp. 33-42
    • Prosser, J.M.1    Nelson, L.S.2
  • 71
    • 84871597310 scopus 로고    scopus 로고
    • Designer drug (DD) abuse in Poland: a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof; part 1 - cannabinoids and cathinones
    • Bilinski P, Holownia P, Kapka-Skrzypczak, et al. Designer drug (DD) abuse in Poland: a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof; part 1 - cannabinoids and cathinones. Ann Agric Environ Med. 2012 ; 19 (4). 857-870
    • (2012) Ann Agric Environ Med , vol.19 , Issue.4 , pp. 857-870
    • Bilinski, P.1    Holownia, P.2    Kapka-Skrzypczak3
  • 72
    • 80053422684 scopus 로고    scopus 로고
    • GHB and synthetic cathinones: clinical effects and potential consequences
    • Karila L, Reynaud M. GHB and synthetic cathinones: clinical effects and potential consequences. Drug Test Analysis. 2011 ; 3 (9). 552-559
    • (2011) Drug Test Analysis , vol.3 , Issue.9 , pp. 552-559
    • Karila, L.1    Reynaud, M.2
  • 73
    • 0025607006 scopus 로고
    • Amphetamine-like effects in humans of the khat alkaloid cathinone
    • Brenneisen R, Fisch HU, Koelbing U, et al. Amphetamine-like effects in humans of the khat alkaloid cathinone. Br J Clin Pharmacol. 1990 ; 30 (6). 825-828
    • (1990) Br J Clin Pharmacol , vol.30 , Issue.6 , pp. 825-828
    • Brenneisen, R.1    Fisch, H.U.2    Koelbing, U.3
  • 74
    • 0028232239 scopus 로고
    • Pharmacodynamics and pharmacokinetics of khat: a controlled study
    • Widler P, Mathys K, Brenneisen R, et al. Pharmacodynamics and pharmacokinetics of khat: a controlled study. Clin Pharmacol Ther. 1994 ; 55 (5). 556-562
    • (1994) Clin Pharmacol Ther , vol.55 , Issue.5 , pp. 556-562
    • Widler, P.1    Mathys, K.2    Brenneisen, R.3
  • 75
    • 84879756491 scopus 로고    scopus 로고
    • Synthetic cathinone abuse
    • Capriola M. Synthetic cathinone abuse. Clin Pharmacol. 2013 ; 5: 109-115
    • (2013) Clin Pharmacol , vol.5 , pp. 109-115
    • Capriola, M.1
  • 77
  • 78
    • 79960773236 scopus 로고    scopus 로고
    • Clinical characteristics of mephedrone toxicity reported to the U.K. National poisons information service
    • James D, Adams RD, Spears R, et al. Clinical characteristics of mephedrone toxicity reported to the U.K. National poisons information service. Emerg Med J. 2011 ; 28 (8). 686-689
    • (2011) Emerg Med J , vol.28 , Issue.8 , pp. 686-689
    • James, D.1    Adams, R.D.2    Spears, R.3
  • 79
    • 77957223512 scopus 로고    scopus 로고
    • London, United Kingdom: Institute of Psychiatry, King's College London Accessed December 29, 2013
    • DelucaPSchifanoFDaveyZ; Psychonaut WebMapping Research Group. Mephedrone Report. London, United Kingdom: Institute of Psychiatry, King's College London; 2010. http://www.psychonautproject.eu/documents/reports/Mephedrone.pdf. Accessed December 29, 2013.
    • (2010) Mephedrone Report
    • Deluca, P.1    Schifano, F.2    Davey, Z.3
  • 80
    • 79952738736 scopus 로고    scopus 로고
    • Survey of current trends in the abuse of psychotropic substances and plants in Japan
    • Rikura-Hanajiri R, Uchiyama N, Goda Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg Med (Tokyo). 2011 ; 13 (3). 109-115
    • (2011) Leg Med (Tokyo) , vol.13 , Issue.3 , pp. 109-115
    • Rikura-Hanajiri, R.1    Uchiyama, N.2    Goda, Y.3
  • 81
    • 84855858697 scopus 로고    scopus 로고
    • Recurrent acute kidney injury following bath salts intoxication
    • Adebamiro A, Perazella MA. Recurrent acute kidney injury following bath salts intoxication. Am J Kidney Dis. 2013 ; 59 (2). 273-275
    • (2013) Am J Kidney Dis , vol.59 , Issue.2 , pp. 273-275
    • Adebamiro, A.1    Perazella, M.A.2
  • 82
    • 84924900939 scopus 로고    scopus 로고
    • "Bath Salt" abuse hits epidemic proportions
    • Erickson T. "Bath Salt" abuse hits epidemic proportions. Emerg Phys Monthly. 2011 ;:
    • (2011) Emerg Phys Monthly
    • Erickson, T.1
  • 84
    • 78650015521 scopus 로고    scopus 로고
    • Mephedrone: new kid for the chop?
    • Winstock AR, Mitcheson LR, Deluca P, et al. Mephedrone: new kid for the chop?. Addiction. 2010 ; 106 (1). 154-161
    • (2010) Addiction , vol.106 , Issue.1 , pp. 154-161
    • Winstock, A.R.1    Mitcheson, L.R.2    Deluca, P.3
  • 85
    • 84867348939 scopus 로고    scopus 로고
    • Synthetic cathinone exposures reported to Texas Poison Centers
    • Forrester MB. Synthetic cathinone exposures reported to Texas Poison Centers. Ann J Drug Alcohol Abuse. 2012 ; 38 (6). 609-615
    • (2012) Ann J Drug Alcohol Abuse , vol.38 , Issue.6 , pp. 609-615
    • Forrester, M.B.1
  • 86
    • 84924900938 scopus 로고    scopus 로고
    • Accessed January 2, 2014
    • Info Sheet: MDPV. http://crew2000.org.uk. Accessed January 2, 2014.
    • Info Sheet: MDPV
  • 87
    • 84871531590 scopus 로고    scopus 로고
    • Pharmacological characterization of designer cathinones in vitro
    • Simmler LD, Buser TA, Schramm Y, et al. Pharmacological characterization of designer cathinones in vitro. Br J Pharmacol. 2013 ; 168 (2). 458-470
    • (2013) Br J Pharmacol , vol.168 , Issue.2 , pp. 458-470
    • Simmler, L.D.1    Buser, T.A.2    Schramm, Y.3
  • 88
    • 33746882802 scopus 로고    scopus 로고
    • Metabolism of the recently encountered designer drug, methylone, in humans and rats
    • Kamata HT, Shima N, Zaitsu K, et al. Metabolism of the recently encountered designer drug, methylone, in humans and rats. Xenobiotica. 2006 ; 36 (8). 709-723
    • (2006) Xenobiotica , vol.36 , Issue.8 , pp. 709-723
    • Kamata, H.T.1    Shima, N.2    Zaitsu, K.3
  • 89
    • 78650716854 scopus 로고    scopus 로고
    • Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS
    • Meyer MR, Du P, Schuster F, et al. Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS. J Mass Spectrom. 2010 ; 45 (12). 1426-1442
    • (2010) J Mass Spectrom , vol.45 , Issue.12 , pp. 1426-1442
    • Meyer, M.R.1    Du, P.2    Schuster, F.3
  • 90
    • 84857462045 scopus 로고    scopus 로고
    • New cathinone-derived designer drugs 3-bromomethcathinone and 3-fluoromethcathinone: studies on their metabolism in rat urine and human liver microsomes using GC-MS and LC-high-resolution MS and their detectability in urine
    • Meyer MR, Vollmar C, Schwaninger AE, et al. New cathinone-derived designer drugs 3-bromomethcathinone and 3-fluoromethcathinone: studies on their metabolism in rat urine and human liver microsomes using GC-MS and LC-high-resolution MS and their detectability in urine. J Mass Spectrom. 2012 ; 47 (2). 253-262
    • (2012) J Mass Spectrom , vol.47 , Issue.2 , pp. 253-262
    • Meyer, M.R.1    Vollmar, C.2    Schwaninger, A.E.3
  • 91
    • 79960603129 scopus 로고    scopus 로고
    • Mephedrone: use, subjective effects and health risks
    • Winstock A, Mitcheson L, Ramsey J, et al. Mephedrone: use, subjective effects and health risks. Addiction. 2011 ; 106 (11). 1991-1996
    • (2011) Addiction , vol.106 , Issue.11 , pp. 1991-1996
    • Winstock, A.1    Mitcheson, L.2    Ramsey, J.3
  • 92
    • 84860488942 scopus 로고    scopus 로고
    • Hyperthermia and multiorgan failure after abuse of "Bath Salts" containing 3,4-methylenedioxypyrovalerone
    • Borek HA, Holstege CP. Hyperthermia and multiorgan failure after abuse of "Bath Salts" containing 3,4-methylenedioxypyrovalerone. Ann Emerg Med. 2012 ; 60 (1). 103-105
    • (2012) Ann Emerg Med , vol.60 , Issue.1 , pp. 103-105
    • Borek, H.A.1    Holstege, C.P.2
  • 93
    • 78649371984 scopus 로고    scopus 로고
    • Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change
    • Dargan PI, Albert S, Wood DM. Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change. Q J Med. 2010 ; 103 (11). 875-879
    • (2010) Q J Med , vol.103 , Issue.11 , pp. 875-879
    • Dargan, P.I.1    Albert, S.2    Wood, D.M.3
  • 94
    • 84860244663 scopus 로고    scopus 로고
    • "A Costly Turn ON": patterns of use and perceived consequences of mephedrone based head shop products amongst Irish injectors
    • Van Hout MC, Bingham T.. "A Costly Turn ON": patterns of use and perceived consequences of mephedrone based head shop products amongst Irish injectors. Int J Drug Policy. 2012 ; 23 (3). 188-197
    • (2012) Int J Drug Policy , vol.23 , Issue.3 , pp. 188-197
    • Van Hout, M.C.1    Bingham, T.2
  • 95
    • 84876686616 scopus 로고    scopus 로고
    • Compartment syndrome after bath salts
    • Levine M, Levitan R, Skoinik A. Compartment syndrome after bath salts. Ann Emerg Med. 2013 ; 61 (4). 480-483
    • (2013) Ann Emerg Med , vol.61 , Issue.4 , pp. 480-483
    • Levine, M.1    Levitan, R.2    Skoinik, A.3
  • 96
    • 81855175325 scopus 로고    scopus 로고
    • Ivory wave: the nextmephedrone?
    • Durham M. Ivory wave: the nextmephedrone?. Emerg Med J. 2011 ; 28 (12). 1059-1060
    • (2011) Emerg Med J , vol.28 , Issue.12 , pp. 1059-1060
    • Durham, M.1
  • 97
    • 80052704897 scopus 로고    scopus 로고
    • Hallucinatory delirium following use of MDPV: "Bath Salts."
    • Penders TM, Gestring R. Hallucinatory delirium following use of MDPV: "Bath Salts.". Gen Hosp Psychiatry. 2011 ; 33 (5). 525-526
    • (2011) Gen Hosp Psychiatry , vol.33 , Issue.5 , pp. 525-526
    • Penders, T.M.1    Gestring, R.2
  • 98
    • 80051712042 scopus 로고    scopus 로고
    • Clinical experience with and analytical confirmation of "bath salts" and "legal highs" (synthetic cathinones) in the United States
    • Spiller HA, Ryan ML, Weston RG, et al. Clinical experience with and analytical confirmation of "bath salts" and "legal highs" (synthetic cathinones) in the United States. Clin Toxicol (Phila). 2011 ; 49 (6). 499-505
    • (2011) Clin Toxicol (Phila) , vol.49 , Issue.6 , pp. 499-505
    • Spiller, H.A.1    Ryan, M.L.2    Weston, R.G.3
  • 100
    • 0032531781 scopus 로고    scopus 로고
    • Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428
    • McCann UD, Wong DF, Yokoi F, et al. Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428. J Neurosci. 1998 ; 18 (20). 8417-8422
    • (1998) J Neurosci , vol.18 , Issue.20 , pp. 8417-8422
    • McCann, U.D.1    Wong, D.F.2    Yokoi, F.3
  • 101
    • 34250308005 scopus 로고    scopus 로고
    • Manganese-induced parkinsonism associated with methcathinone (Ephedrine) abuse
    • De Bie RMA, Gladstone RM, Strafella AP, et al. Manganese-induced parkinsonism associated with methcathinone (Ephedrine) abuse. Arch Neurol. 2007 ; 64 (6). 886-889
    • (2007) Arch Neurol , vol.64 , Issue.6 , pp. 886-889
    • De Bie, R.M.A.1    Gladstone, R.M.2    Strafella, A.P.3
  • 102
    • 40449107628 scopus 로고    scopus 로고
    • A parkinsonian syndrome in methcathinone users and the role of manganese
    • Stepens A, Logina I, Liguts V, et al. A parkinsonian syndrome in methcathinone users and the role of manganese. N Engl J Med. 2008 ; 358 (10). 1009-1017
    • (2008) N Engl J Med , vol.358 , Issue.10 , pp. 1009-1017
    • Stepens, A.1    Logina, I.2    Liguts, V.3
  • 103
    • 34548206713 scopus 로고    scopus 로고
    • Manganic encephalopathy due to "ephedrone" abuse
    • Santosky Y, Lesyk R, Fedoryshyn L, et al. Manganic encephalopathy due to "ephedrone" abuse. Mov Disord. 2007 ; 22 (9). 1337-1343
    • (2007) Mov Disord , vol.22 , Issue.9 , pp. 1337-1343
    • Santosky, Y.1    Lesyk, R.2    Fedoryshyn, L.3
  • 104
    • 84860488943 scopus 로고    scopus 로고
    • Serotonin syndrome associated with MDPV use: a case report
    • Mugele J, Nanagas KA, Tormoehlen LM. Serotonin syndrome associated with MDPV use: a case report. Ann Emerg Med. 2012 ; 60 (1). 100-102
    • (2012) Ann Emerg Med , vol.60 , Issue.1 , pp. 100-102
    • Mugele, J.1    Nanagas, K.A.2    Tormoehlen, L.M.3
  • 105
    • 79952442512 scopus 로고    scopus 로고
    • A case of extreme agitation and death after the use of mephedrone in the Netherlands
    • Lusthof KJ, Oosting R, Maes A, et al. A case of extreme agitation and death after the use of mephedrone in the Netherlands. Forensic Sci Int. 2011 ; 206 (1-3). e93 - e95
    • (2011) Forensic Sci Int , vol.206 , Issue.13 , pp. e93-e95
    • Lusthof, K.J.1    Oosting, R.2    Maes, A.3
  • 106
    • 84870302484 scopus 로고    scopus 로고
    • New "Lethal highs": a case of deadly cocktail of GHB and mephedrone
    • Aromatario M, Bottoni E, Santoni M, et al. New "Lethal highs": a case of deadly cocktail of GHB and mephedrone. Forensic Sci Int. 2012 ; 223 (1-3). e38 - e41
    • (2012) Forensic Sci Int , vol.223 , Issue.13 , pp. e38-e41
    • Aromatario, M.1    Bottoni, E.2    Santoni, M.3
  • 107
    • 77953870712 scopus 로고    scopus 로고
    • Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin
    • Dickson AJ, Vorce SP, Levine B, et al. Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin. J Anal Toxicol. 2010 ; 34 (3). 162-168
    • (2010) J Anal Toxicol , vol.34 , Issue.3 , pp. 162-168
    • Dickson, A.J.1    Vorce, S.P.2    Levine, B.3
  • 108
    • 79954568293 scopus 로고    scopus 로고
    • Mephedrone (4-methylmethcathinone)-related deaths
    • Maskell PD, De Paoli G, Seneviratne C, et al. Mephedrone (4-methylmethcathinone)-related deaths. J Anal Toxicol. 2011 ; 35 (3). 188-191
    • (2011) J Anal Toxicol , vol.35 , Issue.3 , pp. 188-191
    • Maskell, P.D.1    De Paoli, G.2    Seneviratne, C.3
  • 109
    • 84883454546 scopus 로고    scopus 로고
    • Bath salts intoxication: a case series
    • Imam SF, Patel H, Mahmoud M, et al. Bath salts intoxication: a case series. J Emerg Med. 2013 ; 45 (3). 361-365
    • (2013) J Emerg Med , vol.45 , Issue.3 , pp. 361-365
    • Imam, S.F.1    Patel, H.2    Mahmoud, M.3
  • 110
    • 84872800164 scopus 로고    scopus 로고
    • Fatal mephedrone intoxication - a case report
    • Adamowicz P, Tokarczyk B, Stanaszek, et al. Fatal mephedrone intoxication - a case report. J Anal Toxicol. 2013 ; 37 (1). 37-42
    • (2013) J Anal Toxicol , vol.37 , Issue.1 , pp. 37-42
    • Adamowicz, P.1    Tokarczyk, B.2    Stanaszek3
  • 111
    • 84857748270 scopus 로고    scopus 로고
    • Death following recreational use of designer drug "Bath Salts" containing 3,4-methylenedioxypyrovalerone (MDPV)
    • Murray BL, Murphy CM, Beuhler MC. Death following recreational use of designer drug "Bath Salts" containing 3,4-methylenedioxypyrovalerone (MDPV). J Med Toxicol. 2012 ; 8 (1). 69-75
    • (2012) J Med Toxicol , vol.8 , Issue.1 , pp. 69-75
    • Murray, B.L.1    Murphy, C.M.2    Beuhler, M.C.3
  • 112
    • 77953172852 scopus 로고    scopus 로고
    • Excited delirium, restraints, and unexpected death
    • Otachbachi M, Cevik C, Bagdure S, et al. Excited delirium, restraints, and unexpected death. Am J Forensic Med Pathol. 2010 ; 31 (2). 107-112
    • (2010) Am J Forensic Med Pathol , vol.31 , Issue.2 , pp. 107-112
    • Otachbachi, M.1    Cevik, C.2    Bagdure, S.3
  • 113
    • 27944488385 scopus 로고    scopus 로고
    • The potential adverse effects of habitual use of Catha edulis (khat)
    • Al Habori M. The potential adverse effects of habitual use of Catha edulis (khat). Expert Opin Drug Saf. 2005 ; 4 (6). 1145-1154
    • (2005) Expert Opin Drug Saf , vol.4 , Issue.6 , pp. 1145-1154
    • Al Habori, M.1
  • 114
    • 78650758648 scopus 로고    scopus 로고
    • The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland
    • Torrance H, Cooper G. The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland. Forensic Sci Int. 2010 ; 202 (1-3). e62 - e63
    • (2010) Forensic Sci Int , vol.202 , Issue.13 , pp. e62-e63
    • Torrance, H.1    Cooper, G.2
  • 115
    • 79952738995 scopus 로고    scopus 로고
    • Two fatal intoxications with the new designer drug methedrone (4-methoxymethcathinone)
    • Wikstrom M, Thelander G, Nystrom I, et al. Two fatal intoxications with the new designer drug methedrone (4-methoxymethcathinone). J Anal Toxicol. 2010 ; 34 (9). 594-598
    • (2010) J Anal Toxicol , vol.34 , Issue.9 , pp. 594-598
    • Wikstrom, M.1    Thelander, G.2    Nystrom, I.3
  • 116
    • 78649684421 scopus 로고    scopus 로고
    • Khat use and monitoring drug use in Europe: the current situation and issues for the future
    • Griffiths P, Lopez D, Sedefov R, et al. Khat use and monitoring drug use in Europe: the current situation and issues for the future. J Ethnopharmacol. 2010 ; 132 (3). 578-583
    • (2010) J Ethnopharmacol , vol.132 , Issue.3 , pp. 578-583
    • Griffiths, P.1    Lopez, D.2    Sedefov, R.3
  • 117
    • 79960637052 scopus 로고    scopus 로고
    • Current awareness of piperazines: pharmacology and toxicology
    • Elliott S. Current awareness of piperazines: pharmacology and toxicology. Drug Test Anal. 2011 ; 3 (7-8). 430-438
    • (2011) Drug Test Anal , vol.3 , Issue.78 , pp. 430-438
    • Elliott, S.1
  • 118
    • 7944228547 scopus 로고    scopus 로고
    • Chemistry, pharmacology, toxicology and hepatic metabolism of designer drugs of the amphetamine (Ecstasy), piperazine, and pyrrolidinophenone types
    • Mauer HH, Kraemer T, Springer D, et al. Chemistry, pharmacology, toxicology and hepatic metabolism of designer drugs of the amphetamine (Ecstasy), piperazine, and pyrrolidinophenone types. Ther Drug Monit. 2004 ; 26: 127-131
    • (2004) Ther Drug Monit , vol.26 , pp. 127-131
    • Mauer, H.H.1    Kraemer, T.2    Springer, D.3
  • 119
    • 0035664224 scopus 로고    scopus 로고
    • The pharmacology and toxicology of "Ecstasy" (MDMA) and related drugs
    • Kalant H. The pharmacology and toxicology of "Ecstasy" (MDMA) and related drugs. CMAJ. 2001 ; 165 (7). 917-928
    • (2001) CMAJ , vol.165 , Issue.7 , pp. 917-928
    • Kalant, H.1
  • 121
    • 29844451040 scopus 로고    scopus 로고
    • Toxic effect of BZP-based herbal party pills in humans: a prospective study in Christchurch, New Zealand
    • Gee P, Richardson S, Woltersdorf W, et al. Toxic effect of BZP-based herbal party pills in humans: a prospective study in Christchurch, New Zealand. N Z Med J. 2005 ; 118 (1227). 1-10
    • (2005) N Z Med J , vol.118 , Issue.1227 , pp. 1-10
    • Gee, P.1    Richardson, S.2    Woltersdorf, W.3
  • 122
    • 0019976292 scopus 로고
    • 1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole
    • Fong MH, Garattini S, Caccia S. 1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole. J Pharm Pharmacol. 1982 ; 34 (10). 674-675
    • (1982) J Pharm Pharmacol , vol.34 , Issue.10 , pp. 674-675
    • Fong, M.H.1    Garattini, S.2    Caccia, S.3
  • 123
  • 124
    • 33645700807 scopus 로고    scopus 로고
    • Prevalence of use, epidemiology and toxicity of 'herbal party pills' among those presenting to the emergency department
    • Nicholson TC. Prevalence of use, epidemiology and toxicity of 'herbal party pills' among those presenting to the emergency department. Emerg Med Australas. 2006 ; 18 (2). 180-184
    • (2006) Emerg Med Australas , vol.18 , Issue.2 , pp. 180-184
    • Nicholson, T.C.1
  • 125
    • 56749174797 scopus 로고    scopus 로고
    • Patterns of benzylpiperazine/trifluoromethylphenylpiperazine party pill use and adverse effects in a population sample of New Zealand
    • Wilkins C, Sweetsur P, Girling M. Patterns of benzylpiperazine/trifluoromethylphenylpiperazine party pill use and adverse effects in a population sample of New Zealand. Drug Alcohol Rev. 2008 ; 27 (6). 633-639
    • (2008) Drug Alcohol Rev , vol.27 , Issue.6 , pp. 633-639
    • Wilkins, C.1    Sweetsur, P.2    Girling, M.3
  • 126
    • 37749038585 scopus 로고    scopus 로고
    • Highs and lows: patterns of use, positive and negative effects of benzylpiperazine-containing party pills (BZP-party pills) amongst young people in New Zealand
    • Butler RA, Sheridan JL. Highs and lows: patterns of use, positive and negative effects of benzylpiperazine-containing party pills (BZP-party pills) amongst young people in New Zealand. Harm Reduct J. 2007 ; 4: 18
    • (2007) Harm Reduct J , vol.4 , pp. 18
    • Butler, R.A.1    Sheridan, J.L.2
  • 127
    • 71349086193 scopus 로고    scopus 로고
    • Determining the subjective and physiological effects of BZP on human females
    • Lin JC, Bangs N, Lee H, et al. Determining the subjective and physiological effects of BZP on human females. Psychopharmacology (Berl). 2009 ; 207 (3). 439-446
    • (2009) Psychopharmacology (Berl) , vol.207 , Issue.3 , pp. 439-446
    • Lin, J.C.1    Bangs, N.2    Lee, H.3
  • 128
    • 79953665710 scopus 로고    scopus 로고
    • Determining the subjective and physiological effects of BZP combined with TFMPP in human males
    • Lin JC, Jan RK, Lee H, et al. Determining the subjective and physiological effects of BZP combined with TFMPP in human males. Psychopharmacology (Berl). 2011 ; 214 (3). 761-768
    • (2011) Psychopharmacology (Berl) , vol.214 , Issue.3 , pp. 761-768
    • Lin, J.C.1    Jan, R.K.2    Lee, H.3
  • 129
    • 62549160855 scopus 로고    scopus 로고
    • Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants
    • Antia U, Lee HS, Kydd RR, et al. Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants. Forensic Sci Int. 2009 ; 186 (1-3). 63-67
    • (2009) Forensic Sci Int , vol.186 , Issue.13 , pp. 63-67
    • Antia, U.1    Lee, H.S.2    Kydd, R.R.3
  • 130
    • 70449473781 scopus 로고    scopus 로고
    • In vivo interactions between BZP and TFMPP (party pill drugs)
    • Antia U, Tingle MD, Russel BR. In vivo interactions between BZP and TFMPP (party pill drugs). N Z Med J. 2009 ; 122 (1303). 29-38
    • (2009) N Z Med J , vol.122 , Issue.1303 , pp. 29-38
    • Antia, U.1    Tingle, M.D.2    Russel, B.R.3
  • 131
    • 55949121058 scopus 로고    scopus 로고
    • Toxicity from the recreational use of 1-benzylpiperazine
    • Gee P, Gilbert M, Richardson S, et al. Toxicity from the recreational use of 1-benzylpiperazine. Clin Toxicol. 2008 ; 46 (9). 802-807
    • (2008) Clin Toxicol , vol.46 , Issue.9 , pp. 802-807
    • Gee, P.1    Gilbert, M.2    Richardson, S.3
  • 132
    • 84871605801 scopus 로고    scopus 로고
    • Designer Drug (DD) abuse in Poland: a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof: part II - piperazines/piperidines, phenylethylamines, tryptamines and miscellaneous 'others'
    • Bilinski P, Holownia P, Kapka-Skrzypczak, et al. Designer Drug (DD) abuse in Poland: a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof: part II - piperazines/piperidines, phenylethylamines, tryptamines and miscellaneous 'others'. Ann Agric Environm Med. 2012 ; 19 (4). 871-882
    • (2012) Ann Agric Environm Med , vol.19 , Issue.4 , pp. 871-882
    • Bilinski, P.1    Holownia, P.2    Kapka-Skrzypczak3
  • 133
    • 84857759598 scopus 로고    scopus 로고
    • Here today, gone tomorrow... and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (Bath Salts), Kratom, Salvia divinorum, methoxetamine, and piperazines
    • Rosenbaum CD, Carreiro SP, Babu KM. Here today, gone tomorrow... and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (Bath Salts), Kratom, Salvia divinorum, methoxetamine, and piperazines. J Med Toxicol. 2012 ; 8 (1). 15-32
    • (2012) J Med Toxicol , vol.8 , Issue.1 , pp. 15-32
    • Rosenbaum, C.D.1    Carreiro, S.P.2    Babu, K.M.3
  • 134
    • 79954476887 scopus 로고    scopus 로고
    • The clinical toxicology of the designer "party pills" benzylpiperazine and trifluoromethylphenylpiperazine
    • Schep LJ, Slaughter RJ, Vale JA, et al. The clinical toxicology of the designer "party pills" benzylpiperazine and trifluoromethylphenylpiperazine. Clin Toxicol (Phila). 2011 ; 49 (3). 131-141
    • (2011) Clin Toxicol (Phila) , vol.49 , Issue.3 , pp. 131-141
    • Schep, L.J.1    Slaughter, R.J.2    Vale, J.A.3
  • 135
    • 10444270218 scopus 로고    scopus 로고
    • Effects of "Legal X" piperazine analogs on dopamine and serotonin release in rat brain
    • Baumann MH, Clark RD, Budzynski AG, et al. Effects of "Legal X" piperazine analogs on dopamine and serotonin release in rat brain. Ann N Y Acad Sci. 2004 ; 1025: 189-197
    • (2004) Ann N Y Acad Sci , vol.1025 , pp. 189-197
    • Baumann, M.H.1    Clark, R.D.2    Budzynski, A.G.3
  • 136
    • 13944249599 scopus 로고    scopus 로고
    • N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy')
    • Baumann MH, Clark RD, Budzynski AG, et al. N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy'). Neuropsychopharmacology. 2005 ; 30 (3). 550-560
    • (2005) Neuropsychopharmacology , vol.30 , Issue.3 , pp. 550-560
    • Baumann, M.H.1    Clark, R.D.2    Budzynski, A.G.3
  • 137
    • 0031902715 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic profile of oral and intravenous meta-chlorophenylpiperazine in healthy volunteers
    • Gijsman HK, Van Gerven J, Tieleman MC, et al. Pharmacokinetic and pharmacodynamic profile of oral and intravenous meta-chlorophenylpiperazine in healthy volunteers. J Clin Psychopharmacol. 1998 ; 18 (4). 298-295
    • (1998) J Clin Psychopharmacol , vol.18 , Issue.4 , pp. 298-295
    • Gijsman, H.K.1    Van Gerven, J.2    Tieleman, M.C.3
  • 138
    • 77951266660 scopus 로고    scopus 로고
    • Multiorgan failure from 1-benzylpiperazine ingestion - legal high or lethal high?
    • Gee P, Jerram T, Bowie D. Multiorgan failure from 1-benzylpiperazine ingestion - legal high or lethal high?. Clin Toxicol (Phila). 2010 ; 48 (3). 230-233
    • (2010) Clin Toxicol (Phila) , vol.48 , Issue.3 , pp. 230-233
    • Gee, P.1    Jerram, T.2    Bowie, D.3
  • 139
    • 33646551443 scopus 로고    scopus 로고
    • Nephrotoxicity of BZP-based herbal party pills: a New Zealand case report
    • Alansari M, Hamilton D. Nephrotoxicity of BZP-based herbal party pills: a New Zealand case report. N Z Med J. 2006 ; 119 (1233). 1-3
    • (2006) N Z Med J , vol.119 , Issue.1233 , pp. 1-3
    • Alansari, M.1    Hamilton, D.2
  • 140
    • 33847336461 scopus 로고    scopus 로고
    • Benzylpiperazine-based party pills' impact on the Auckland city hospital emergency department overdose database (2002-2004) compared with ecstasy (MDMA or methylenedioxymethamphetamine), gamma hydroxybutyrate (GHB), amphetamines, cocaine, and alcohol
    • Theron L, Jansen K, Miles J. Benzylpiperazine-based party pills' impact on the Auckland city hospital emergency department overdose database (2002-2004) compared with ecstasy (MDMA or methylenedioxymethamphetamine), gamma hydroxybutyrate (GHB), amphetamines, cocaine, and alcohol. N Z Med J. 2007 ; 120: U2416
    • (2007) N Z Med J , vol.120 , pp. 2416
    • Theron, L.1    Jansen, K.2    Miles, J.3
  • 141
    • 34247400599 scopus 로고    scopus 로고
    • Collapse, reported seizure - and an unexpected pill
    • Wood DM, Dargan PI, Button K, et al. Collapse, reported seizure - and an unexpected pill. Lancet. 2007 ; 369 (9571). 1490
    • (2007) Lancet , vol.369 , Issue.9571 , pp. 1490
    • Wood, D.M.1    Dargan, P.I.2    Button, K.3
  • 142
    • 76149084512 scopus 로고    scopus 로고
    • Piperazines: a new class of drug of abuse has landed in Hong Kong
    • Poon WT, Lai CF, Lui MC, et al. Piperazines: a new class of drug of abuse has landed in Hong Kong. Hong Kong Med J. 2010 ; 16 (1). 76-77
    • (2010) Hong Kong Med J , vol.16 , Issue.1 , pp. 76-77
    • Poon, W.T.1    Lai, C.F.2    Lui, M.C.3
  • 143
    • 60749124571 scopus 로고    scopus 로고
    • Dissociative and sympathomimetic toxicity associated with recreational use of 1(-3-trifluoromethylphenyl) piperazine (TFMPP) and 1-benzylpiperazine (BZP)
    • Wood DM, Button J, Lidder S, et al. Dissociative and sympathomimetic toxicity associated with recreational use of 1(-3-trifluoromethylphenyl) piperazine (TFMPP) and 1-benzylpiperazine (BZP). J Med Toxicol. 2008 ; 4 (4). 254-257
    • (2008) J Med Toxicol , vol.4 , Issue.4 , pp. 254-257
    • Wood, D.M.1    Button, J.2    Lidder, S.3
  • 144
    • 48249142826 scopus 로고    scopus 로고
    • Detection of 1-benzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS
    • Vorce SP, Holler JM, Levine B, et al. Detection of 1-benzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS. J Anal Toxicol. 2008 ; 32 (6). 444-450
    • (2008) J Anal Toxicol , vol.32 , Issue.6 , pp. 444-450
    • Vorce, S.P.1    Holler, J.M.2    Levine, B.3
  • 145
    • 34250632332 scopus 로고    scopus 로고
    • The prevalence of use, dependency and harms of legal 'party pills' containing benzylpiperazine (BZP) and trifluorophenylmethylpiperazine (TFMPP) in New Zealand
    • Wilkins C, Girling M, Sweetsur P. The prevalence of use, dependency and harms of legal 'party pills' containing benzylpiperazine (BZP) and trifluorophenylmethylpiperazine (TFMPP) in New Zealand. J Subst Abuse. 2007 ; 12: 213-224
    • (2007) J Subst Abuse , vol.12 , pp. 213-224
    • Wilkins, C.1    Girling, M.2    Sweetsur, P.3
  • 146
    • 40549143061 scopus 로고    scopus 로고
    • Investigation of the first deaths in the United Kingdom involving the detection and quantification of the piperazines BZP and 3-TFMPP
    • Elliott S, Smith C. Investigation of the first deaths in the United Kingdom involving the detection and quantification of the piperazines BZP and 3-TFMPP. J Anal Toxicol. 2008 ; 32 (2). 172-177
    • (2008) J Anal Toxicol , vol.32 , Issue.2 , pp. 172-177
    • Elliott, S.1    Smith, C.2
  • 147
    • 79954621258 scopus 로고    scopus 로고
    • Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples
    • Dickson AJ, Vorce SP, Holler JM, et al. Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples. J Anal Toxicol. 2010 ; 34 (8). 464-469
    • (2010) J Anal Toxicol , vol.34 , Issue.8 , pp. 464-469
    • Dickson, A.J.1    Vorce, S.P.2    Holler, J.M.3
  • 148
    • 0035885296 scopus 로고    scopus 로고
    • Piperazine-like compounds: a new group of designer drugs-of-abuse on the European market
    • De Boer D, Bosman IJ, Hidvegi E, et al. Piperazine-like compounds: a new group of designer drugs-of-abuse on the European market. Forensic Sci Int. 2001 ; 121 (1-2). 47-56
    • (2001) Forensic Sci Int , vol.121 , Issue.12 , pp. 47-56
    • De Boer, D.1    Bosman, I.J.2    Hidvegi, E.3
  • 149
    • 77955468163 scopus 로고    scopus 로고
    • Determining the subjective effects of TFMPP in human males
    • Jan RK, Lin JC, Lee H, et al. Determining the subjective effects of TFMPP in human males. Psychopharmacology. 2010 ; 211 (3). 347-353
    • (2010) Psychopharmacology , vol.211 , Issue.3 , pp. 347-353
    • Jan, R.K.1    Lin, J.C.2    Lee, H.3
  • 150
    • 12144269150 scopus 로고    scopus 로고
    • Acute psychosis following ingestion of 'Rapture'
    • Austin H, Monasterio E. Acute psychosis following ingestion of 'Rapture'. Australas Psychiatry. 2004 ; 12 (4). 406-408
    • (2004) Australas Psychiatry , vol.12 , Issue.4 , pp. 406-408
    • Austin, H.1    Monasterio, E.2
  • 152
    • 84924900937 scopus 로고    scopus 로고
    • CID = 16078, CID = 10382701, CID = 15942731, CID = 9821569. Accessed January 2, 2014
    • National Center for Biotechnology Information PubChem Compound. CID = 16078, CID = 10382701, CID = 15942731, CID = 9821569. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid. Accessed January 2, 2014.
    • National Center for Biotechnology Information PubChem Compound1
  • 153
    • 84924900936 scopus 로고    scopus 로고
    • CID = 10836, CID = 62258, CID = 20111961, CID = 45266826. Accessed January 3, 2014
    • National Center for Biotechnology Information PubChem Compound. CID = 10836, CID = 62258, CID = 20111961, CID = 45266826. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid. Accessed January 3, 2014.
    • National Center for Biotechnology Information PubChem Compound1
  • 154
    • 84924900935 scopus 로고    scopus 로고
    • CID = 1615, CID = 75994, CID = 3084246. Accessed January 3, 2014
    • National Center for Biotechnology Information PubChem Compound. CID = 1615, CID = 75994, CID = 3084246. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid. Accessed January 3, 2014.
    • National Center for Biotechnology Information PubChem Compound1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.