‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs?

Journal of Mass Spectrometry

Volumn 44, Issue 5, 2009, Pages 832-837

  Auwärter, Volker ^a   Dresen, Sebastian ^a   Weinmann, Wolfgang ^a   Müller, Michael ^b   Pütz, Michael ^c   Ferreirós, Nerea ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Federal Criminal Police Office   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALKALOID; ALPHA TOCOPHEROL; AUCUBIN; BETA TOCOPHEROL; CANNABINOID DERIVATIVE; DESIGNER DRUG; GAMMA TOCOPHEROL; LEONURINE; OLEAMIDE; CANNABINOID; PLANT MEDICINAL PRODUCT;

CONJUNCTIVA; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG OVERDOSE; DRUG SCREENING; DRUG URINE LEVEL; HUMAN; INHALANT ABUSE; INTELLECTUAL IMPAIRMENT; LETTER; MASS FRAGMENTOGRAPHY; MOLECULAR WEIGHT; MOOD CHANGE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PULSE RATE; SIGNAL DETECTION; SOLID PHASE EXTRACTION; THIN LAYER CHROMATOGRAPHY; CHEMISTRY;

ALKALOIDS; CANNABINOIDS; DESIGNER DRUGS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; PLANT PREPARATIONS;

EID: 66249133962     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1558     Document Type: Letter

References (11)

1. C.A. Mueller, W. Weinmann, S. Dresen, A. Schreiber, M. Gergov. Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching. Rapid Communications in Mass Spectrometry 2005, 79,1332.
2. J.W.Huffman, G.Zengin, M.J. Wu, J.Lu, G. Hynd, K.Bushell, A.L.Thompson, S.Bushell, C.Tartal, D.P.Hurst, P.H.Reggio, D. E. Selley, M. P. Cassidy, J. L. Wiley, B. R. Martin. Structure-activity relationships for 1-alkyl-3-(1- naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. Bioorganic and Medicinal Chemistry 20 05, 73,89.
3. M.M.Aung, G. Griffin, J.W.Huffman, M.Wu, C. Keel, B.Yang, V. M. Showalter, M. E. Abood, B. R. Martin. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding. Drug and Alcohol Dependence 2000,60,133.
4. X. Q. Xie, D.P.Yang, L. S. Melvin, A. Makriyannis. Conformational analysis of the prototype nonclassical cannabinoid CP-47,497, using 2D NMR and computer molecular modeling. Journal of Medicinal Chemistry 1994,37,1418.
5. L. S. Melvin, G. M. Milne, M. R. Johnson, B. Subramaniam, G. H. Wilken, A. C. Howlett. Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bi- cyclic cannabinoid analogs. Molecular Pharmacology 1993,44,1008.
6. L.S.Melvin, M. R. Johnson, C. A.Harbert, G. M.Milne, A. Weissman. A cannabinoid derived prototypical analgesic. Journal of Medicinal Chemistry 1984,27,67.
7. B.K.Koe, G.M.Milne, A.Weissman, M.R.Johnson, L.S.Melvin. Enhancement of brain [3H]flunitrazepam binding and analgesic activity of synthetic cannabimimetics. European Journal of Pharmacology 1985, 109, 201.
8. D.R.Compton, M.R.Johnson, L.S.Melvin, B.R.Martin. Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents. Journal of Pharmacology and Experimental Therapeutics 1992,260, 201.
9. A. Weissman, G. M. Milne, L. S. Melvin Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. Journal of Pharmacology and Experimental Therapeutics 1982,223, 516.
10. G. A. Thakur, S. P. Nikas, A. Makriyannis. CB1 cannabinoid receptor ligands. Mini Reviews in Medicinal Chemistry 2005,5,631.
11. D. Stumptner, J.Kempf, W. Weinmann. Increase of extraction efficiency for THC in serum by larger SPE cartridges (German). In: GTFCH-Symposium 2003: Ausgewählte Aspekte der Forensischen Toxikologie. Hrsg.: F. Pragst, R. Aderjan, Verlag Dr. Dieter Helm, Heppenheim 2004.