"Spice" and "k2" herbal highs: A case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans

American Journal on Addictions

Volumn 21, Issue 4, 2012, Pages 320-326

  Gunderson, Erik W ^a,b   Haughey, Heather M ^a   Ait Daoud, Nassima ^a   Joshi, Amruta S ^a   Hart, Carl L ^b,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 NAPHTHOYL) 1 PENTYLINDOLE; CANNABINOID RECEPTOR AGONIST; CANNABIS; CP 47 497; JWH 073; LORAZEPAM; OLEAMIDE; SYNTHETIC CANNABINOID; UNCLASSIFIED DRUG;

AGITATION; ANXIETY; ARTICLE; BIOLOGICAL ACTIVITY; BLURRED VISION; CANNABIS ADDICTION; COGNITIVE DEFECT; CONJUNCTIVA DISEASE; DEPRESSION; DIAPHORESIS; DIARRHEA; DISEASES; DISORIENTATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG TOLERABILITY; EYE BURNING; FASCICULATION; FATIGUE; FEAR; GAIT DISORDER; HALLUCINATION; HEADACHE; HEART PALPITATION; HERBAL MEDICINE; HOT FLUSH; HUMAN; HYPERTENSION; HYPOKALEMIA; INSOMNIA; INTERNAL UNREST; IRRITABILITY; MEMORY DISORDER; MOOD; NAUSEA; NIGHTMARE; NYSTAGMUS; PANIC; PARANOIA; PSYCHOSIS; PUBLIC HEALTH; PULSE RATE; SEDATION; SHORT TERM MEMORY DEFECT; SIDE EFFECT; SOCIAL PSYCHOLOGY; SYSTEMATIC REVIEW; TACHYCARDIA; THOUGHT DISORDER; TIME PERCEPTION; TREMOR; VISUAL HALLUCINATION; WEAKNESS; WITHDRAWAL SYNDROME; XEROSTOMIA;

ADULT; CANNABINOIDS; HUMANS; MALE; MARIJUANA ABUSE; RECEPTOR, CANNABINOID, CB1; SUBSTANCE WITHDRAWAL SYNDROME; TETRAHYDROCANNABINOL;

EID: 84862768861     PISSN: 10550496     EISSN: 15210391     Source Type: Journal    
DOI: 10.1111/j.1521-0391.2012.00240.x     Document Type: Article

References (39)

1. New York: United Nations Office on Drugs and Crime (UNODC). UNODC, World Drug Report-2009. New York: United Nations Office on Drugs and Crime; 2009.
2. Substance Abuse and Mental Health Services Administration. Results from the 2008 National Survey on Drug Use and Health: National Findings (Office of Applied Studies, NSDUH Series H-36, HHS Publication No. SMA 09-4434). Rockville, MD; 2009.
3. Budney AJ, Moore BA, Vandrey RG, et al,. The time course and significance of cannabis withdrawal. J Abnorm Psychol. 2003; 112: 393-402. (Pubitemid 36959365)
4. Hart CL., Increasing treatment options for cannabis dependence: A review of potential pharmacotherapies. Drug Alcohol Depend. 2005; 80: 147-159. (Pubitemid 41427630)
5. European Monitoring Centre for Drugs and Drug Addiction. Action on new drugs briefing paper: Understanding the 'spice' phenomenon. 2009. Available at:. Accessed May 16, 2011.
6. U.S. Department of Justice, National Drug Intelligence Center. Drug alert watch: Use of synthetic cannabinoid products by teens and young adults increasing. EWS Report 000006. May 18, 2010. Available at:. Accessed May 16, 2011.
7. Advisory Council on the Misuse of Drugs (ACMD). Consideration of the major cannabinoid agonists. 2009. Available at:. Accessed May 16, 2011.
8. Hillebrand J, Olszewski D, Sedefov R,. Legal highs on the Internet. Subst Use Misuse. 2010; 45: 330-340.
9. Uchiyama N, Kikura-Hanajiri R, Ogata J, et al,. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Sci Int. 2010; 198: 31-38.
10. Auwarter V., 'Spice' and other herbal blends: Harmless incense or cannabinoid designer drugs? J Mass Spectrom. 2009; 44: 832-837.
11. Lindigkeit R, Boehme A, Eiserloh I, et al,. Spice: A never ending story? Forensic Sci Int. 2009; 191: 58-63.
12. Emanuel CEJ, Ellison B, Banks CE,. Spice up your life: Screening the illegal components of 'Spice' herbal products. Anal Meth. 2010; 2: 614-616.
13. Dresen S, Ferreiros N, Putz M, et al,. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J Mass Spectrom. 2010; 45: 1186-1194.
14. United States Drug Enforcement Agency. Office of Forensic Sciences. Intelligence alert: "Spice"-Plant material(s) laced with synthetic cannabinoids or cannabinoid mimicking compounds. Microgram Bulletin. 2009; 42: 23-24. Retrieved from:. Accessed May 16, 2011.
15. Psychonaut Web Mapping Research Group. Spice Report. London, UK: Institute of Psychiatry, King's College London; 2009. Available at:. Accessed May 16, 2011.
16. 9- tetrahydrocannabivarin. Brit J Pharmacol. 2007; 153: 199-215.
17. O'Brien C,. Drug addiction and drug abuse. In:, Bruton LL, Lazo JS, Parker KL, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 11th edn. New York, NY: The McGraw-Hill Company, Inc.; 2006: 621-642.
18. U.S. Drug Enforcement Agency. Chemicals used in "Spice" and "K2" type products now under federal control and regulation. News Release Number: 202-307-7977, March 1, 2011. Available at:. Accessed May 16, 2011.
19. Zimmermann US, Winkelmann PR, Pilhatsch M, et al,. Withdrawal phenomena and dependence syndrome after the consumption of "Spice Gold". Dtsch Arztebl Int. 2009; 106: 464-467.
20. Müller H, Sperling W, Köhrmann M, et al,. The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes. Schizophr Res. 2010; 108: 309-310.
21. Müller H, Huttner HB, Köhrmann M, et al,. Panic attack after Spice abuse in a patient with ADHD. Pharmacopsychiatry. 2010; 43: 152-153.
22. Vearrier D, Osterhoudt KC,. A teenager with agitation: Higher than she should have climbed. Pediatr Emerg Care. 2010; 26: 462-465.
23. Schneir AB, Cullen J, Ly BT,. "Spice" girls: Synthetic cannabinoid intoxication. J Emerg Med. 2011; 40: 296-299.
24. Every-Palmer S. Synthetic cannabinoid JWH-018 and psychosis: An explorative study. Drug Alcohol Depend. 2011; 117: 152-157.
25. Teske J, Weller JP, Fleguth A, et al,. Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl) methanone (JWH-018) in human serum by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010; 878: 2659-2663.
26. Sobolevsky T, Prasolov I, Rodchenkov G,. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci Int. 2010; 200: 141-147.
27. Wehrman J., Fake marijuana spurs more than 2000 calls to U.S. poison centers this year alone. AAPCC. November 22, 2010. Available at:. Accessed May 16, 2011.
28. Scalzo A,. Epi-X The Epidemic Information Exchange. K2 Synthetic Marijuana Use Among Teenagers-Missouri, 2010. Available at. Accessed March 6, 2012.
29. Haney M., The marijuana withdrawal syndrome: Diagnosis and treatment. Curr Psychiatry Rep. 2005; 7: 360-366. (Pubitemid 41684183)
30. Haney M, Hart CL, Vosburg SK, et al,. Marijuana withdrawal in humans: Effects of oral THC or divalproex. Neuropsychopharmacology. 2004; 29: 158-170. (Pubitemid 38068026)
31. Pawaolski J., Pot substitutes lack controls. The Olympian. 2010. Available at:. Accessed May 16, 2011.
32. Bronstein AC, Spyker DA, Cantilena LR, et al,. 2008 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 26th Annual Report. Clin Toxicol. 2009; 47: 911-1084. Available at:. Accessed May 16, 2011.
33. Tetrault JM, Crothers K, Moore BA, et al,. Effects of marijuana smoking on pulmonary function and respiratory complications: A systematic review. Arch Intern Med. 2007; 167: 221-228.
34. "K2 controversy continues." Drug News. CelebStoner. 2010 Feb 17. Available at:. Accessed May 16, 2011.
35. Hazekamp A, Ruhaak R, Zuurman L, et al,. Evaluation of a vaporizing device (Volcano) for the pulmonary administration of tetrahydrocannabinol. J Pharm Sci. 2006; 95: 1308-1317. (Pubitemid 43874444)
36. Schmidt M, Sharma A, Schifano F, Feinmann C,. "Legal highs" on the net-Evaluation of UK based Websites, products and product information. Forensic Sci Int. 2011; 206: 92-97.
37. Griffiths P., How globalization and market innovation challenge how we think about and respond to drug use: 'Spice' a case study. Addiction. 2010; 105: 951-953.
38. Vardakou I, Pistos C, Spiliopoulou CH,. Spice drugs as a new trend: Mode of action, identification and legislation. Toxicol Lett. 2010; 197: 157-162.
39. Dargan PI, Hudson S, Ramsey J, Wood DM,. The impact of changes in UK classification of the synthetic cannibinoid receptor agonists in 'Spice'. Int J Drug Policy. 2011; 22: 274-277.