Synthetic cannabinoid intoxication: A case series and review

Journal of Emergency Medicine

Volumn 44, Issue 2, 2013, Pages 360-366

  Harris, Carson R ^a   Brown, Ashley ^a  

^a REGIONS HOSPITAL   (United States)

Author keywords

HU 210; JWH 078; K2; Spice drugs; synthetic cannabinoids

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABIS; DRONABINOL; TETRAHYDROCANNABINOL;

ADOLESCENT; ADULT; CLINICAL ARTICLE; CLINICAL FEATURE; DEPRESSION; DRUG INTOXICATION; EMERGENCY WARD; FAINTNESS; FEMALE; HALLUCINATION; HUMAN; HYPERREFLEXIA; MALE; MENTAL HEALTH; MYOCLONUS; NAUSEA; NEUROLOGIC EXAMINATION; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT; SEIZURE; SOMNOLENCE; SUICIDAL IDEATION; TACHYCARDIA; THORAX PAIN; URINALYSIS; VOMITING;

EID: 84873157996     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2012.07.061     Document Type: Article

References (25)

1. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) Forensic identification, pharmacology and toxicology of synthetic cannabinoids Thematic papers. Understanding the 'Spice' phenomenon 2009 European Monitoring Centre for Drugs and Drug Addiction Lisbon Available at http://www.emcdda.europa.eu/ publications/thematic-papers/spice Accessed October 18, 2010
2. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) Synthetic cannabinoid receptor agonists: a brief chemical overview Thematic papers. Understanding the 'Spice' phenomenon 2009 European Monitoring Centre for Drugs and Drug Addiction Lisbon Available at http://www.emcdda.europa.eu/ publications/thematic-papers/spice Accessed October 18, 2010
3. I. Vardakou, C. Pistos, and C. Spiliopoulou Spice drugs as a new trend: mode of action, identification and legislation Toxicol Lett 197 2010 157 162
4. Georgia General Assembly. HB 1309: Controlled substances; add synthetic cannabinoids to Schedule 1 list; provide. Available at: http://www.legis.ga.gov/ legis/2009-10/search/hb1309.htm. Accessed October18, 2010.
5. Louisiana Legislature. Regular session, 2010; Act No. 866. Available at: http://www.legis.state.la.us/billdata/streamdocument.asp?did=723192. Accessed October 18, 2010.
6. Michigan Legislature. Controlled substance schedules HB 6038 (S-1) and 6226 (S-2): floor summary. Available at: http://www.Legislature.mi.gov/ documents/2009-2010/billanalysis/Senate/htm/2009-SFA-6038-F.htm. Accessed October18, 2010.
7. United States Drug Enforcement Administration (DEA). Public Affairs news release: DEA moves to emergency control synthetic marijuana. Washington DC: DEA; November 24, 2010. Available at: http://www.justice.gov/dea/pubs/pressrel/ pr112410.html. Accessed December 3, 2010.
8. R.G. Pertwee Pharmacology of cannabinoid receptor ligands Curr Med Chem 6 1999 635 664
9. R.G. Pertwee The pharmacology of cannabinoid receptors and their ligands: an overview Int J Obes (Lond) 30 Suppl 1 2006 S13 S18
10. B.H. McCarberg, and R.L. Barkin The future of cannabinoids as analgesic agents: a pharmacologic, pharmacokinetic, and pharmacodynamic overview Am J Ther 14 2007 475 483
11. J.C. Ashton, J.L. Wright, J.M. McPartland, and J.D.A. Tyndall Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists Curr Med Chem 15 2008 1428 1443
12. A. Wintermeyer, I. Möller, and M. Thevis In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal Bioanal Chem 398 2010 2141 2153
13. R.G. Pertwee Cannabinoid pharmacology: the first 66 years Br J Pharmacol 147 Suppl 1 2006 S163 S171
14. J.W. Huffman, and K.C. Marriott Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor Curr Top Med Chem 8 2008 187 204
15. M.D. Van Sickle, M. Duncan, and P.J. Kingsley Identification and functional characterization of brainstem cannabinoid CB2 receptors Science 310 2005 329 332
16. M.M. Aung, G. Griffin, and J.W. Huffman Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB (1) and CB (2) receptor binding Drug Alcohol Depend 60 2000 133 140
17. V. Auwärter, S. Dresen, and W. Weinmann 'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs? J Mass Spectrom 44 2009 832 837
18. I. Möller, A. Wintermeyer, and K. Bender Screening for the synthetic cannabinoid JWH-018 and its major metabolites in human doping controls Drug Test Anal 3 2011 609 620
19. C. Falkowski Drug abuse trends in Minneapolis/St. Paul, Minnesota January 2011 Minnesota Department of Human Services St. Paul
20. P. Cary Drug court practitioner fact sheet. Spice, K2 and the problem of synthetic cannabinoids 2010 National Drug Court Institute Alexandria, VA
21. N. Laaris, C.H. Good, and C.R. Lupica Δ9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus Neuropharmacology 59 2010 121 127
22. A.F. Hoffman, and C.R. Lupica Mechanisms of cannabinoid inhibition of GABAA synaptic transmission in the hippocampus J Neurosci 20 2000 2470 2479
23. United States Department of Justice, Drug Enforcement Administration, Office of Diversion Control. Spice Cannabinoid. Drug Enforcement Agency, 2009. Available at: http://www.deadiversion.usdoj.gov/drugs-concern/spice/. Accessed October 18, 2010.
24. National Conference of State Legislatures Synthetic drug threats 2010 National Conference of State Legislatures Denver, CO Available at http://www.ncsl.org/?TabId=21398 Accessed November 24, 2011
25. Erowid Center. Documenting the complex relationship between humans & psychoactives. Available at: erowid.org. Accessed April 7, 2012.