Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine, and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples

Journal of Analytical Toxicology

Volumn 34, Issue 8, 2010, Pages 464-469

  Dickson, Amber J ^a   Vorce, Shawn P ^a   Holler, Justin M ^a   Lyons, Timothy P ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 1 BENZYLPIPERAZINE DERIVATIVE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; PSYCHOTROPIC AGENT;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG SCREENING; HUMAN; LIQUID LIQUID EXTRACTION; MASS FRAGMENTOGRAPHY; URINALYSIS;

EID: 79954621258     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/34.8.464     Document Type: Article

References (23)

1. N.J. Astor, M.F. Hehir, and S.H. Roper. Illicit tablet trends in Georgia. Presented at the Joint Associat ion Meet ing of SAFS/MAFS/MAAFS/SWAFS, Orlando, FL, October 18-23, 2009.
2. U.S. Drug Enforcement Administration. Ecstasy mimic tablets (actually containing trifluoromethylphenylpiperazine and dapox-etine) in Alabama. Microgram Bull. 42(12): 93-94 (2009).
3. U.S. Drug Enforcement Administration. Unusual BZP tablets in NewYork. Microgram Bull. 42(8): 70 (2009).
4. U.S. Drug Enforcement Administration. Ecstasy/piperazine com-bination tablets in NewYork. Microgram Bull. 42(8): 70 (2009).
5. U.S. Drug Enforcement Administration.Various tablets containing BZP and TFMPP inWashington, D.C. Microgram Bull. 42(7): 64 (2009).
6. U.S. Drug Enforcement Administration. Ecstasy mimic tablets (actual ly containing N-benzylpiperazine (BZP), 1- (3-trifluoromethyl)phenylpiperazine (TFMPP), and caffeine in Asheville, North Carolina. Microgram Bull. 42(6): 53-54 (2009).
7. U.S. Drug Enforcement Administration. New trend in ecstasy tablets seen in southwestern U.S. Microgram Bull. 42(6): 54-55 (2009).
8. U.S. Drug Enforcement Administration. Obama, Snoopy, and other BZP tablet trends appear in Oklahoma. Microgram Bull. 42(6): 55 (2009).
9. U.S. Drug Enforcement Administration. BZP tablets in NewYork, NewYork. Microgram Bull. 42(6): 58 (2009).
10. U.S. Drug Enforcement Administration. Ecstasy mimic tablets (actually containing N-benzylpiperazine (BZP) and caffeine) in Tucson, Arizona. Microgram Bull. 42(5): 45-46 (2009).
11. U.S. Drug Enforcement Administration. Ecstasy mimic tablets (actually containing BZP, 1-(3-trifluoromethyl)phenylpiperazine (TFMPP), caffeine, and 1,4-dibenzylpiperazine) in Olathe, Kansas. Microgram Bull. 42(5): 46 (2009).
12. U.S. Drug Enforcement Administration. Ecstasy mimic tablets (actually containing BZP, TFMPP, and dextromethorphan) in Tiffin, Ohio. Microgram Bull. 42(5): 46-47 (2009).
13. U.S. Drug Enforcement Administration. Ecstasy mimic tablets (actually containing 1-(3-chlorophenyl)-piperazine (mCPP)) in Pasadena, Texas. Microgram Bull. 42(5): 47-48 (2009).
14. U. Antia, H.S. Lee, R.R. Kyd, M.D. Tingle, and B.R. Russell. Phar-macokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants. Forensic Sci. Int. 186: 63-67 (2009).
15. U.S. Drug Enforcement Administration. Ecstasy and ecstasy com-bination tablets (containing MDMA, methamphetamine, and co-caine) in Medford, Oregon. Microgram Bull. 42(4): 35-36 (2009).
16. U.S. Drug Enforcement Administration. Ecstasy combination tablets (containing MDMA, ketamine, and caffeine) in Amarillo, Texas. Microgram Bull. 42(4): 39 (2009).
17. C.Wilkins, M. Girling, and P. Sweetsur. The prevalence of use, de-pendency and harms of legal 'party pills' containing ben-zylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) in New Zealand. J. Subst. Use 12: 213-223 (2007).
18. S. Elliott and C. Smith. Investigation of the first deaths in the United Kingdom involving the detection and quantitation of the piperazines BZP and 3-TFMPP. J. Anal. Toxicol. 32: 172-177 (2008).
19. S.P. Vorce, J.M. Holler, B. Levine, and M.R. Past. Detection of 1-benyzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS. J. Anal. Toxicol. 32: 444-450 (2008).
20. J.M. Holler, S.P.Vorce, T.Z. Bosy, and A. Jacobs. Quantitative and isomeric determination of amphetamine and methamphetamine from urine using a nonprotic elution solvent and R(-)α(-methoxy-(-trifluoromethylphenylacetic acid chloride derivatization. J.Anal. Toxicol. 29: 652-657 (2005)
21. R.C. Baselt. Disposition of Toxic Drugs and Chemicals in Man, 7th ed. Biomedical Publications, Foster City, CA, 2004.
22. National Drug Intelligence Center. National Drug Threat Assess-ment 2009. Product No. 2008-Q0317-005. U.S. Department of Justice, Johnstown, PA, 2008.
23. D.M. Wood, J. Button, S. Lidder, J. Ramsey, D.W. Holt, and P.I. Dargan. Dissociative and sympathomimetic toxicity associated with recreational use of 1-(3-trifluoromethylphenyl)piperazine (TFMPP) and 1-benzylpiperazine (BZP). J. Med. Toxicol. 4(4): 254-257 (2008)