JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist

British Journal of Pharmacology

Volumn 160, Issue 3, 2010, Pages 585-593

  Atwood, Brady K ^a,b   Huffman, John ^c   Straiker, Alex ^a   MacKie, Ken ^a  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c CLEMSON UNIVERSITY   (United States)

Author keywords

Cannabinoid; ERK1 2; Internalization; JWH018; MAPK; Marijuana; Neurotransmission; Spice; THC

Indexed keywords

3 (1 NAPHTHOYL) 1 PENTYLINDOLE; ADENYLATE CYCLASE; CANNABINOID 1 RECEPTOR AGONIST; NAPHTHALEN 1 YL (1 PENTYLINDOL 3 YL)METHANONE; UNCLASSIFIED DRUG; 1-PENTYL-3-(1-NAPHTHOYL)INDOLE; CANNABINOID; CANNABINOID 1 RECEPTOR; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; NAPHTHALENE DERIVATIVE; PLANT MEDICINAL PRODUCT; PSYCHEDELIC AGENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; GENE ACTIVATION; HIPPOCAMPUS; INTERNALIZATION; MOUSE; NERVE ENDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; CULTURE TECHNIQUE; DOSE RESPONSE; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; HUMAN; INBRED MOUSE STRAIN; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; SYNAPTIC TRANSMISSION; TRANSFORMED CELL LINE;

ANIMALS; CANNABINOIDS; CELL CULTURE TECHNIQUES; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY POSTSYNAPTIC POTENTIALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HALLUCINOGENS; HIPPOCAMPUS; HUMANS; INDOLES; MICE; MICE, INBRED STRAINS; NAPHTHALENES; NEURONS; PHOSPHORYLATION; PLANT PREPARATIONS; RECEPTOR, CANNABINOID, CB1; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 77952664328     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00582.x     Document Type: Article

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