Effects of acute detoxification of the herbal blend 'Spice Gold' on dopamine D2/3 receptor availability: A [18F]fallypride PET study

European Neuropsychopharmacology

Volumn 23, Issue 11, 2013, Pages 1606-1610

  Rominger, Axel ^a   Cumming, Paul ^a   Xiong, Guoming ^a   Koller, Gabriele ^a   Förster, Stefan ^b   Zwergal, Andreas ^a   Karamatskos, Evangelos ^a   Bartenstein, Peter ^a   La Fougère, Christian ^a   Pogarell, Oliver ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Addiction; Cannabinoid; Dopamine D2 3 receptor; PET; Spice

Indexed keywords

CANNABINOID; CANNABIS; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; FALLYPRIDE F 18; HERBACEOUS AGENT; TRACER; UNCLASSIFIED DRUG;

ABSTINENCE; ADDICTION; ADULT; ARTICLE; BRAIN REGION; CANNABIS ADDICTION; CASE REPORT; CONTROLLED STUDY; DETOXIFICATION; FOLLOW UP; HUMAN; IMAGE PROCESSING; MALE; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SMOKING; SYMPTOM; WITHDRAWAL SYNDROME;

ADDICTION; CANNABINOID; DOPAMINE D(2/3) RECEPTOR; PET; SPICE;

BENZAMIDES; BRAIN; CASE-CONTROL STUDIES; FLUORINE RADIOISOTOPES; FUNCTIONAL NEUROIMAGING; HUMANS; MALE; METABOLIC DETOXICATION, DRUG; PLANT PREPARATIONS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SUBSTANCE WITHDRAWAL SYNDROME; YOUNG ADULT;

EID: 84886774491     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2013.01.009     Document Type: Article

References (15)

1. Albrecht D.S., Skosnik P.D., Vollmer J.M., Brumbaugh M.S., Perry K.M., Mock B.H., Zheng Q.H., Federici L.A., Patton E.A., Herring C.M., Yoder K.K. Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users. Drug Alcohol Depend. 2013, 128(1-2), 52-57.
2. Auwarter V., Dresen S., Weinmann W., Muller M., Putz M., Ferreiros N. 'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs?. J. Mass Spectrom. 2009, 44:832-837.
3. Bossong M.G., van Berckel B.N., Boellaard R., Zuurman L., Schuit R.C., Windhorst A.D., van Gerven J.M., Ramsey N.F., Lammertsma A.A., Kahn R.S. Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology 2009, 34:759-766.
4. Dresen S., Ferreiros N., Putz M., Westphal F., Zimmermann R., Auwarter V. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J. Mass Spectrom. 2010, 45:1186-1194.
5. Huestis M.A., Gorelick D.A., Heishman S.J., Preston K.L., Nelson R.A., Moolchan E.T., Frank R.A. Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716. Arch. Gen. Psychiatry 2001, 58:322-328.
6. Logan J., Fowler J.S., Volkow N.D., Wang G.J., Ding Y.S., Alexoff D.L. Distribution volume ratios without blood sampling from graphical analysis of PET data. J. Cereb. Blood Flow Metab. 1996, 16:834-840.
7. Martinez D., Gil R., Slifstein M., Hwang D.R., Huang Y., Perez A., Kegeles L., Talbot P., Evans S., Krystal J., Laruelle M., Abi-Dargham A. Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum. Biol. Psychiatry 2005, 58:779-786.
8. Mata I., Rodriguez-Sanchez J.M., Pelayo-Teran J.M., Perez-Iglesias R., Gonzalez-Blanch C., Ramirez-Bonilla M., Martinez-Garcia O., Vazquez-Barquero J.L., Crespo-Facorro B. Cannabis abuse is associated with decision-making impairment among first-episode patients with schizophrenia-spectrum psychosis. Psychol. Med. 2008, 38:1257-1266.
9. Mukherjee J., Christian B.T., Dunigan K.A., Shi B., Narayanan T.K., Satter M., Mantil J. Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors. Synapse 2002, 46:170-188.
10. Rominger A., Cumming P., Xiong G., Koller G., Boning G., Wulff M., Zwergal A., Forster S., Reilhac A., Munk O., Soyka M., Wangler B., Bartenstein P., la Fougere C., Pogarell O. [18F]fallypride PET measurement of striatal and extrastriatal dopamine D 2/3 receptor availability in recently abstinent alcoholics. Addict. Biol. 2012, 17:490-503.
11. Stokes P.R., Egerton A., Watson B., Reid A., Lappin J., Howes O.D., Nutt D.J., Lingford-Hughes A.R. History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability. J. Psychopharmacol. 2012, 26:144-149.
12. Stokes P.R., Mehta M.A., Curran H.V., Breen G., Grasby P.M. Can recreational doses of THC produce significant dopamine release in the human striatum?. Neuroimage 2009, 48:186-190.
13. Volkow N.D., Chang L., Wang G.J., Fowler J.S., Ding Y.S., Sedler M., Logan J., Franceschi D., Gatley J., Hitzemann R., Gifford A., Wong C., Pappas N. Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. Am. J. Psychiatry 2001, 158:2015-2021.
14. Volkow N.D., Fowler J.S., Wang G.J., Baler R., Telang F. Imaging dopamine's role in drug abuse and addiction. Neuropharmacology 2009, 56(Supplement 1):S3-S8.
15. Volkow N.D., Wang G.J., Maynard L., Fowler J.S., Jayne B., Telang F., Logan J., Ding Y.S., Gatley S.J., Hitzemann R., Wong C., Pappas N. Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study. Psychiatry Res. 2002, 116:163-172.