Linear polyethylenimine-plasmid DNA nanoparticles are ototoxic to the cultured sensory epithelium of neonatal mice

Molecular Medicine Reports

Volumn 11, Issue 6, 2015, Pages 4381-4388

  Zhou, Han ^a   Ma, Xiaofeng ^a   Liu, Yongze ^b   Dong, Lei ^c   Luo, Yi ^c   Zhu, Guangjie ^a   Qian, Xiaoyun ^a   Chen, Jie ^a   Lu, Lin ^a   Wang, Junguo ^a   Gao, Xia ^a  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Cochlear sensory epithelium; Linear polyethylenimine; Nanoparticles; Oto nanotoxicity

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; PLASMID DNA; POLYETHYLENEIMINE; NANOPARTICLE;

ARTICLE; CELL CULTURE; CELL DAMAGE; CELL MEMBRANE; COCHLEA; DNA TRANSFER; EPITHELIUM CELL; ESCHERICHIA COLI; EXPLANT; FEMALE; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IN VITRO GENE TRANSFER; IN VIVO STUDY; INNER HAIR CELL; MALE; MOUSE; NANOMEDICINE; NANOTECHNOLOGY; NANOTOXICOLOGY; NEUROEPITHELIUM; NEWBORN; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OTOTOXICITY; OUTER HAIR CELL; REPORTER GENE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CHEMISTRY; EPITHELIUM; GENE EXPRESSION; GENE TRANSFER; GENETICS; HAIR CELL; METABOLISM; PATHOLOGY; PLASMID; ULTRASTRUCTURE;

MUS;

ANIMALS; ANIMALS, NEWBORN; COCHLEA; EPITHELIUM; FEMALE; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HAIR CELLS, AUDITORY; MALE; MICE; NANOPARTICLES; PLASMIDS; POLYETHYLENEIMINE; TRANSFECTION;

EID: 84924690160     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3306     Document Type: Article

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