Gene transfer with modified polyethylenimines

Journal of Gene Medicine

Volumn 6, Issue SUPPL. 1, 2004, Pages

  Kichler, Antoine ^a  

^a GÉNÉTHON   (France)

Author keywords

DNA transfection; Endosomolytic activity; Polyethylene glycol; Polyethylenimine; Receptor mediated; Surface charge

Indexed keywords

ALBUMIN; ASIALOGLYCOPROTEIN; COPOLYMER; DNA; EPIDERMAL GROWTH FACTOR; FOLIC ACID; GALACTOSE; LECTIN; LIGAND; LIPOPLEX; LIPOSOME; LUCIFERASE; MACROGOL; MANNOSE; MELITTIN; PLASMID DNA; POLYETHYLENEIMINE DERIVATIVE; TRANSFERRIN; VIRUS VECTOR; DRUG DERIVATIVE; MACROGOL DERIVATIVE; POLYETHYLENEIMINE;

CELL STRAIN 3T3; CELL STRAIN HEPG2; CYTOTOXICITY; DNA TRANSFECTION; ENDOCYTOSIS; ERYTHROCYTE AGGREGATION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HUMAN; HYDROPHILICITY; IN VITRO STUDY; KUPFFER CELL; LUNG ALVEOLUS CELL; MACROPHAGE ACTIVATION; MOLECULAR WEIGHT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN BINDING; REPORTER GENE; REVIEW; SURFACE CHARGE; VIRUS INFECTION; ZETA POTENTIAL; ANIMAL; GENETIC TRANSFECTION;

ANIMALS; GALACTOSE; HUMANS; LIGANDS; MELITTEN; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; TRANSFECTION;

EID: 3242807724     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.507     Document Type: Review

References (57)

1. Boussif O, Lezoualc'h F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.
2. Boussif O, Zanta MA, Behr JP. Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold. Gene Ther 1996; 3: 1074-1080.
3. Zou SM, Erbacher P, Remy JS, Behr JP. Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J Gene Med 2000; 2: 128-134.
4. Tang MX, Szoka FC. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther 1997; 4: 823-832.
5. Kichler A, Behr JP, Erbacher P. Polyethylenimines: a family of potent polymers for nucleic acid delivery. In Non-viral Vectors for Gene Therapy, Huang L, Hung M-C, Wagner E (eds). Academic Press: San Diego, 1999; 191-206.
6. Mislick KA, Baldeschwieler JD. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc Natl Acad Sci U S A 1996; 93: 12 349-12 354.
7. Mounkes LC, Zhong W, Cipres-Palacin G, Heath TD, Debs RJ. Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo. J Biol Chem 1998; 273: 26 164-26 170.
8. Ogris M, Brunner S, Schuller S, Kircheis R, Wagner E. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther 1999; 6: 595-605.
9. Eliyahu H, Servel N, Domb AJ, Barenholz Y. Lipoplex-induced hemagglutination: potential involvement in intravenous gene delivery. Gene Ther 2002; 9: 850-858.
10. Liu F, Qi H, Huang L, Liu D. Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration. Gene Ther 1997; 4: 517-523.
11. Mahato RI, Anwer K, Tagliaferri F, et al. Biodistribution and gene expression of lipid/plasmid complexes after systemic administration. Hum Gene Ther 1998; 9: 2083-2099.
12. Barron LG, Gagne L, Szoka FC Jr. Lipoplex-mediated gene delivery to the lung occurs within 60 minutes of intravenous administration. Hum Gene Ther 1999; 10: 1683-1694.
13. Templeton NS, Lasic DD, Frederik PM, Strey HH, Roberts DD, Pavlakis GN. Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nat Biotechnol 1997; 15: 647-652.
14. Liu Y, Mounkes LC, Liggitt HD, et al. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery. Nat Biotechnol 1997; 15: 167-173.
15. Goula D, Benoist C, Mantero S, Merlo G, Levi G, Demeneix BA. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther 1998; 5: 1291-1295.
16. Barron LG, Szoka FC. The perplexing delivery mechanism of lipoplexes. In Non-viral Vectors for Gene Therapy, Huang L, Hung M-C, Wagner E (eds). Academic Press: San Diego, 1999; 229-266.
17. Ogris M, Steinlein P, Kursa M, Mechtler K, Kircheis R, Wagner E. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther 1998; 5: 1425-1433.
18. Kircheis R, Wightman L, Wagner E. Design and gene delivery activity of modified polyethylenimines. Adv Drug Deliv Rev 2001; 53: 341-358.
19. Wightman L, Kircheis R, Rossler V, et al. Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J Gene Med 2001; 3: 362-372.
20. Bragonzi A, Boletta. A, Biffi A, et al. Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs. Gene Ther 1999; 6: 1995-2004.
21. Papahadjopoulos D, Allen TM, Gabizon A, et al. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci U S A 1991; 88: 11 460-11 464.
22. Nguyen HK, Lemieux P, Vinogradov SV, et al. Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Ther 2000; 7: 126-138.
23. Kichler A, Chillon M, Leborgne C, Danos O, Frisch B. Intranasal gene delivery with a polyethylenimine-PEG conjugate. J Control Release 2002; 81: 379-388.
24. Petersen H, Fechner PM, Martin AL, et al. Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system. Bioconjug Chem 2002; 13: 845-854.
25. Kichler A, Frisch B, Lima de Souza D, Schuber F. Receptor-mediated gene delivery with non-viral DNA carriers. J Liposome Res 2000; 10: 443-460.
26. Zanta MA, Boussif O, Adib A, Behr JP. In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjug Chem 1997; 8: 839-844.
27. Bettinger T, Remy JS, Erbacher P. Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes. Bioconjug Chem 1999; 10: 558-561.
28. Leclercq F, Dubertret C, Pitard B, Scherman D, Herscovici J. Synthesis of glycosylated polyethylenimine with reduced toxicity and high transfecting efficiency. Bioorg Med Chem Lett 2000; 10: 1233-1235.
29. Diebold SS, Kursa M, Wagner E, Cotten M, Zenke M. Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells. J Biol Chem 1999; 274: 19 087-19 094.
30. Erbacher P, Remy JS, Behr JP. Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther 1999; 6: 138-145.
31. Kircheis R, Kichler A, Wallner G, et al. Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther 1997; 4: 409-418.
32. Kircheis R, Wightman L, Schreiber A, et al. Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application. Gene Ther 2001; 8: 28-40.
33. Blessing T, Kursa M, Holzhauser R, Kircheis R, Wagner E. Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery. Bioconjug Chem 2001; 12 529-537.
34. Ogris M, Steinlein P, Carotta S, Brunner S, Wagner E. DNA/polyethylenimine transfection particles: influence of ligands, polymer size, and PEGylation on internalization and gene expression. AAPS PharmSci 2001; 3: E21.
35. O'Neill MM, Kennedy CA, Barton RW, Tatake RJ. Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine. Gene Ther 2001; 8: 362-368.
36. Li S, Tan Y, Viroonchatapan E, Pitt BR, Huang L. Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody. Am J Physiol Lung Cell Mol Physiol 2000; 278: L504-511.
37. Wu J, Nantz MH, Zern MA. Targeting hepatocytes for drug and gene delivery: emerging novel approaches and applications. Front Biosci 2002; 7: d717-725.
38. Erbacher P, Bettinger T, Belguise-Valladier P, et al. Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody-derivatized polyethylenimines (PEI). J Gene Med 1999; 1: 210-222.
39. Sagara K, Kim SW. A new synthesis of galactose-poly(ethylene glycol)-polyethylenimine for gene delivery to hepatocytes. J Control Release 2002; 79: 271-281.
40. Kursa M, Walker GF, Roessler V, et al. Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. Bioconjug Chem 2003; 14 222-231.
41. Lee H, Kim TH, Park TG. A receptor-mediated gene delivery system using streptavidin and biotin-derivatized, pegylated epidermal growth factor. J Control Release 2002; 83: 109-119.
42. Benns JM, Mahato RI, Kim SW. Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine. J Control Release 2002; 79: 255-269.
43. Kircheis R, Schuller S, Brunner S, et al. Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. J Gene Med 1999; 1: 111-120.
44. Carlisle RC, Bettinger T, Ogris M, Hale S, Mautner V, Seymour LW. Adenovirus hexon protein enhances nuclear delivery and increases transgene expression of polyethylenimine/plasmid DNA vectors. Mol Ther 2001; 4: 473-483.
45. Ogris M, Carlisle RC, Bettinger T, Seymour LW. Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors. J Biol Chem 2001; 276: 47 550-47 555.
46. Thomas M, Klibanov AM. Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A 2002; 99: 14 640-14 645.
47. Han S, Mahato RI, Kim SW. Water-soluble lipopolymer for gene delivery. Bioconjug Chem 2001; 12: 337-345.
48. Gosselin MA, Guo W, Lee RJ. Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjug Chem 2001; 12: 989-994.
49. Jeong JH, Song SH, Lim DW, Lee H, Park TG. DNA transfection using linear poly(ethylenimine) prepared by controlled acid hydrolysis of poly(2-ethyl-2-oxazoline). J Control Release 2001; 73: 391-399.
50. Fischer D, von Harpe A, Kunath K, Petersen H, Li Y, Kissel T. Copolymers of ethyleneimine and N-(2-hydroxyethyl)ethyleneimine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes. Bioconjug Chem 2002; 13: 1124-1133.
51. Petersen H, Merdan T, Kunath K, Fischer D, Kissel T. Poly(ethylenimine-co-L-lactamide-co-succinamide): a biodegradable polyethylenimine derivative with an advantageous pH-dependent hydrolytic degradation for gene delivery. Bioconjug Chem 2002; 13: 812-821.
52. Ahn CH, Chae SY, Bae YH, Kim SW. Biodegradable poly(ethylenimine) for plasmid DNA delivery. J Control Release 2002; 80: 273-282.
53. Brissault B, Kichler A, Guis C, Leborgne C, Danos O, Chéradame H. Synthesis of linear polyethylenimine derivatives for DNA transfection. Bioconjug Chem 2003; 14: 581-587.
54. Demeneix B, Behr J, Boussif O, Zanta MA, Abdallah B, Remy J. Gene transfer with lipospermines and polyethylenimines. Adv Drug Deliv Rev 1998; 30: 85-95.
55. Fischer D, Bieber T, Li Y, Elsasser HP, Kissel T. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res 1999; 16: 1273-1279.
56. Chollet P, Favrot MC, Hurbin A, Coll JL. Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J Gene Med 2002; 4: 84-91.
57. Tang MX, Redemann CT, Szoka FC Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 1996; 7: 703-714.