Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity

European Journal of Medicinal Chemistry

Volumn 94, Issue , 2015, Pages 367-377

  Parrino, Barbara ^a   Carbone, Anna ^a   Spanò, Virginia ^a   Montalbano, Alessandra ^a   Giallombardo, Daniele ^a   Barraja, Paola ^a   Attanzio, Alessandro ^a   Tesoriere, Luisa ^a   Sissi, Claudia ^b   Palumbo, Manlio ^b   Cirrincione, Girolamo ^a   Diana, Patrizia ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antiproliferative activity; Apoptosis; Azaisoindolo quinoxalines; DNA interaction; Isoindolo azaquinoxalines; Quinoxalines

Indexed keywords

1,4 DIMETHOXY 2,3 DIMETHYLPYRIDO[3',2':3,4]PYRROLO[1,2 A]QUINOXALIN 6(5H) IMINE; 1,4 DIMETHOXYPYRIDO[2',3':3,4]PYRROLO[1,2 A]QUINOXALIN 6(5H) IMINE; 1,4 DIMETHOXYPYRIDO[3'2,':3,4]PYRROLO[1,2 A]QUINOXALIN 6(5H) IMINE; 2 (2 AMINOPYRIDIN 3 YL) 2H ISOINDOLE 1 CARBONITRILE; 2 (2 AMINOPYRIDIN 3 YL) 5,6 DIMETHOXY 2H ISOINDOLE 1 CARBONITRILE; 2 (2 AMINOPYRIDIN 3 YL) 5,6 DIMETHYL 2H ISOINDOLE 1 CARBONITRILE; 2,3 DICHLOROPYRIDO[2',3':3,4]PYRROLO[1,2 A]QUINOXALIN 6(5H) IMINE; 2,3 DICHLOROPYRIDO[3',2':3,4]PYRROLOL[1,2 A]QUINOXALIN 6(5H) IMINE; 2,3 DIMETHOXYPYRIDO[3',2':3,4]PYRROLO[1,2 A]QUINOXALIN 6(5H) IMINE; 2,3 DIMETHYLPYRIDO[2',3':3,4]PYRROLO[1,2 A]QUINOXALIN 6(5H)IMINE; 2,3 DIMETHYLPYRIDO[3',2':3,4]PYRROLOL[1,2 A]QUINIXALIN 6(5H) IMINE; 3 METHOXYPYRIDO[2',3':3,4]PYRROLO[1,2 A]QUINOXALIN 6(5H) IMINE; 6 (2 AMINO 3,6 DIMETHOXY 4,5 DIMETHYLPHENYL) 6H PYRROLO [3,4 B]PYRIDINE 5 CARBONITRILE; 6 (2 AMINO 3,6 DIMETHOXY 4,5 DIMETHYLPHENYL) 6H PYRROLO [3,4 B]PYRIDINE 7 CARBONITRILE; 6 (2 AMINO 3,6 DIMETHOXYPHENYL) 6 PYRROLO[3,4 B]PYRIDINE 5 CARBONITRILE; 6 (2 AMINO 3,6 DIMETHOXYPHENYL) 6H PYRROLO[3,4 B]PYRIDINE 7 CARBONITRILE; 6 (2 AMINO 4 METHOXYPHENYL) 6H PYRROLO[3,4 B]PYRIDINE 5 CARBONITRILE; 6 (2 AMINO 4,5 DICHLOROPHENYL) 6H PYRROLO[3,4 B]PYRIDINE 5 CARBONITRILE; 6 (2 AMINO 4,5 DICHLOROPHENYL) 6H PYRROLO[3,4 B]PYRIDINE 7 CARBONITRILE; 6 (2 AMINO 4,5 DIMETHOXYPHENYL) 6H PYRROLO[3,4 B]PYRIDINE 5 CARBONITRILE; 6 (2 AMINO 4,5 DIMETHOXYPHENYL) 6H PYRROLO[3,4 B]PYRIDINE 7 CARBONITRILE; 6 (2 AMINO 4,5 DIMETHYLPHENYL) 6H PYRROLO[3.4 B]PYRIDINE 5 CARBONITRILE; 6 (2 AMINO 4,5 DIMETHYLPHENYL) 6H PYRROLO[3.4 B]PYRIDINE 7 CARBONITRILE; 6 (2 AMINOPHENYL) 6H PYRROLO[3,4 B]PYRIDINE 5 CARBONITRILE; 6 (2 AMINOPHENYL) 6H PYRROL[3,4 B]PYRIDINE 5 CARBONITRILE; ANTINEOPLASTIC AGENT; AZA ISOINDOLO DERIVATIVE; ISOINDOLO AZAQUINOXALINE DERIVATIVE; PYRIDOL[3',2':3,4]PYRROLO[1,2 A]QUINOXALIN 6(5H) IMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; HETEROCYCLIC COMPOUND; ISOINDOLE DERIVATIVE; QUINOXALINE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; DNA BINDING; G2 PHASE CELL CYCLE CHECKPOINT; HCT116 CELL LINE; HUMAN; HUMAN CELL; NATIONAL HEALTH ORGANIZATION; TUMOR CELL LINE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AZA COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOINDOLES; MOLECULAR STRUCTURE; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84924608884     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.03.009     Document Type: Article

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