Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action

European Journal of Medicinal Chemistry

Volumn 94, Issue , 2015, Pages 149-162

  Parrino, Barbara ^a   Carbone, Anna ^a   Ciancimino, Cristina ^a   Spanò, Virginia ^a   Montalbano, Alessandra ^a   Barraja, Paola ^a   Cirrincione, Girolamo ^a   Diana, Patrizia ^a   Sissi, Claudia ^b   Palumbo, Manlio ^b   Pinato, Odra ^b   Pennati, Marzia ^c   Beretta, Giovanni ^c   Folini, Marco ^c   Matyus, Peter ^d   Balogh, Balázs ^d   Zaffaroni, Nadia ^c  

^a UNIVERSITY OF PALERMO   (Italy)

^b Department of Pharmaceutical and Pharmacological Sciences ^*  (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Antitubulin agents; G quadruplex interaction; Isoindolo 2,1 a quinoxalin 6 imines; Topoisomerase I inhibitors

Indexed keywords

1,4 DIMETHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINE; 1,4 DIMETHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 10 FLUORO 3 HYDROXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 10 FLUORO 4 METHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINE; 2 METHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINE; 2 METHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 2,3 DICHLOROISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 2,3 DIMETHYLISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 3 HYDROXY 8,9 DIMETHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 3 HYDROXY 8,9 DIMETHYLISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 3 HYDROXY 9 METHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 3 METHOXY 8,9 DIMETHYLISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINE; 3 METHOXY 8,9 DIMETHYLISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 3 METHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 3,8 DIMETHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINE; 3,8,9 TRIMETHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINE; 3,8,9 TRIMETHOXYISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 4 METHYLISOINDOLO[2,1 A]QUINOXALIN 6(5H) IMINIUM ACETATE; 6 IMINO 8,9 DIMETHOXY 5,6 DIHYDROISOINDOLO[2,1 A]QUINOXALIN 3 OL; 6 IMINO 8,9 DIMETHYL 5,6 DIHYDROISOINDOLO[2,1 A]QUINOXALIN 3 OL; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; IMINE; ISOINDOLE DERIVATIVE; ISOINDOLO[2,1 A]QUINOXALIN 6 IMINE DERIVATIVE; NAVELBINE; PACLITAXEL; QUINOXALINE DERIVATIVE; TUBULIN MODULATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; DNA TOPOISOMERASE; TUBULIN; WATER;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG MECHANISM; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; MICROTUBULE ASSEMBLY; NATIONAL HEALTH ORGANIZATION; TELOMERE; TUMOR CELL LINE; CELL CYCLE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MICROTUBULE; PROCEDURES; SOLUBILITY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMINES; MICROTUBULES; QUINOXALINES; SOLUBILITY; TUBULIN; WATER;

EID: 84924423190     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.03.005     Document Type: Article

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