11 H -pyrido[3′,2′:4,5]pyrrolo[3,2- c ]cinnoline and Pyrido[3′,2′:4,5]pyrrolo[1,2- c ][1,2,3]benzotriazine: Two new ring systems with antitumor activity

Journal of Medicinal Chemistry

Volumn 57, Issue 22, 2014, Pages 9495-9511

  Parrino, Barbara ^a   Carbone, Anna ^a   Muscarella, Marina ^a   Spanò, Virginia ^a   Montalbano, Alessandra ^a   Barraja, Paola ^a   Salvador, Alessia ^b   Vedaldi, Daniela ^b   Cirrincione, Girolamo ^a   Diana, Patrizia ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 2,3,8,9 TETRAMETHOXYDIBENZO[B,F][1,5]DIAZOCINE 6,12 (5H,11H)DIIMINE; 2,8 DICHLORODIBENZO[B,F][1,5]DIAZOCINE 6,12(5H,11H)DIIMINE; 3,9 DICHLORODIBENZO[B,F][1,5]DIAZOCINE 6,12(5H,11H)DIIMINE; 3,9 DIMETHOXYDIBENZO[B,F][1,5]DIAZOCINE 6,12(5H,11H)DIIMINE; 3,9 DIMETHYLDIBENZO[B,F][1,5]DIAZOCINE 6,12(5H,11H)DIIMINE; 4 CHLORO 2 (1H PYRROLO[2,3-B]PYRIDIN 2 YL)ANILINE; 4 CHLORO 2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 4,5 DIMETHOXY 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 5 CHLORO 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 5 CHLORO 2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 5 METHOXY 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 5 METHOXY 2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 5 METHYL 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; 5 METHYL 2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)ANILINE; ANTINEOPLASTIC AGENT; DIBENZO[B,F][1,5]DIAZOCINE 6,12(5H,11H)DIIMINE; N[2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[4 CHLORO 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[4 CHLORO 2 (3 NITROSO 1H PYRROLO[2,3-B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[4,5 DIMETHOXY 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[4,5 DIMETHOXY 2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[5 CHLORO 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[5 METHOXY 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[5 METHOXY 2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[5 METHYL 2 (1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; N[5 METHYL 2 (3 NITROSO 1H PYRROLO[2,3 B]PYRIDIN 2 YL)PHENYL]ACETAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; CASPASE; CASPASE INHIBITOR; CINNOLINE; FUSED HETEROCYCLIC RINGS; REACTIVE OXYGEN METABOLITE; TRIAZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CENTRAL NERVOUS SYSTEM TUMOR; COLON CANCER; COLONY FORMATION; CONTROLLED STUDY; CYTOMETRY; DEPOLARIZATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; JURKAT CELL LINE; LEUKEMIA CELL LINE; MELANOMA CELL LINE; NON SMALL CELL LUNG CANCER; PROSTATE CANCER CELL LINE; RENAL CANCER CELL LINE; CELL CYCLE; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CHEMISTRY; ENZYMOLOGY; LYSOSOME; MEDICINAL CHEMISTRY; MITOCHONDRION; NEOPLASMS; PROCEDURES; TEMPERATURE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE INHIBITORS; CASPASES; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; ENZYME ACTIVATION; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; JURKAT CELLS; LYSOSOMES; MITOCHONDRIA; NEOPLASMS; REACTIVE OXYGEN SPECIES; TEMPERATURE; TRIAZINES;

EID: 84913570543     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501244f     Document Type: Article

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