Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity

Journal of Medicinal Chemistry

Volumn 42, Issue 14, 1999, Pages 2561-2568

  Cirrincione, Girolamo ^a   Almerico, Anna Maria ^a   Barraja, Paola ^a   Diana, Patrizia ^a   Lauria, Antonino ^a   Passannanti, Alessandra ^a   Musiu, Chiara ^b   Pani, Alessandra ^b   Murtas, Paola ^b   Minnei, Carla ^b   Marongiu, M Elena ^b   La Colla, Paolo ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

10 METHOXY 12 NITROSOINDOLO[1,2 C]BENZO[1,2,3]TRIAZINE; 10 NITRO 12 NITROSOINDOLO[1,2 C]BENZO[1,2,3]TRIAZINE; 2 CHLORO 12 NITROSOINDOLO[1,2 C]BENZO[1,2,3]TRIAZINE; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; STAPHYLOCOCCUS; STREPTOCOCCUS;

ANTI-BACTERIAL AGENTS; ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; BACTERIA; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES; TUMOR CELLS, CULTURED;

EID: 0033566132     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9806087     Document Type: Article

References (10)

1. Wakelin, L. P. G.; Waring, M. J. DNA Intercalating Agents. In Comprehensive Medicinal Chemistry; Sammes, P. G., Ed.; Pergamon Press: Oxford, U.K., 1990; Vol 2, pp 703-724.
2. 1H NMR Study of Binding Mode and Kinetics. J. Med. Chem. 1984, 27, 450-465.
3. Watson, J. D.; Hopkins, N. H.; Roberts, J. W.; Steitz, J. A.; Weiner, A. M. In Molecular Biology of the Gene, 4th ed.; Benjamin/Cummings Publishing Co.: Reading, MA, 1987; Vol. I, p 255.
4. Myers, C. E., Jr.; Chabner, B. A. In Cancer Chemotherapy: Principles and Practice; Chabner, B. A., Collins, J. M., Eds.; Lippincott: Philadelphia, PA, 1990; p 356.
5. Hertzberg, R. P. Agents Interfering with DNA Enzymes. In Comprehensive Medicinal Chemistry; Sammes, P. G., Ed.; Pergamon Press: Oxford, U.K., 1990; Vol. 2, pp 753-791.
6. Cirrincione, G.; Almerico, A. M.; Barraja, P.; Diana, P.; Grimaudo, G.; Mingoia, F.; Dattolo, G.; Aiello, E. Polycondensed Nitrogen Heterocycles. Part 27. Indolo[3,2-c]cinnoline. Synthesis and Antileukemic Activity. Farmaco 1995, 50, 849-852.
7. Aiello, E.; Dattolo, G.; Cirrincione, G.; Almerico, A. M.; D'Asdia, I. Preparation of Monohalopyrroles. J. Heterocycl. Chem. 1982, 19, 977-979.
8. Cirrincione, G.; Almerico, A. M.; Aiello, E.; Dattolo, G. Polycondensed Nitrogen Heterocycles. Part 23. Pyrrolo[3,2-c]cinnolines by a Japp-Klingemann Type Reaction. J. Heterocycl. Chem. 1990, 27, 983-985.
9. Denizot, F.; Lang, R. Rapid colorimetric assay for cell growth and survival. J. Immunol. Methods 1986, 89, 271-277.
10. Pauwels, R.; Balzarini, J.; Baba, M.; Snoeck, R.; Scholds, D.; Herdewijn, P.; Desmyter, J.; De Clercq, E. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. J. Virol. Methods 1988, 20, 309-321.