Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues

Marine Drugs

Volumn 13, Issue 1, 2015, Pages 460-492

  Carbone, Anna ^a   Parrino, Barbara ^a   Vita, Gloria Di ^a   Attanzio, Alessandro ^a   Spanò, Virginia ^a   Montalbano, Alessandra ^a   Barraja, Paola ^a   Tesoriere, Luisa ^a   Livrea, Maria Antonia ^a   Diana, Patrizia ^a   Cirrincione, Girolamo ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Antiproliferative activity; Apoptosis; Autophagic death; Bis indolyl alkaloids; Indolyl thiazolyl pyrrolo 2,3 c pyridines; Marine alkaloids; Nortopsentins; Thiazolyl bis pyrrolo 2,3 b pyridines

Indexed keywords

1 METHYL 3 [4 (1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 2 YL] 1H PYRROLO[2,3 B]PYRIDINE; 1 METHYL 3 [4 (1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 B]PYRIDINE; 3 [2 (5 BROMO 1 METHYL 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 7 CHLORO 1 METHYL 1H PYRROLO[2,3 C]PYRIDINE; 3 [2 (5 BROMO 1 METHYL 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 7 CHLORO 1H PYRROLO[2,3 C]PYRIDINE; 3 [2 (5 BROMO 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 7 CHLORO 1H PYRROLO[2,3 C]PYRIDINE; 3 [4 (5 BROMO 1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 2 YL] 1 METHYL 1H PYRROLO[2,3 B]PYRIDINE; 3 [4 (5 FLUORO 1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 2 YL] 1 METHYL 1H PYRROLO[2,3 B]PYRIDINE; 3,3' (1,3 THIAZOLE 2,4 DIYL)BIS(1 METHYL 1H PYRROLO[2,3 B]PYRIDINE); 3,3' (1,3 THIAZOLE 2,4 DIYL)BIS(1H PYRROLO[2,3 B]PYRIDINE); 5 BROMO 1 METHYL 3 [2 (1 METHYL 1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 B]PYRIDINE; 5 BROMO 1 METHYL 3 [2 (1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 B]PYRIDINE; 5 BROMO 3[2 (1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 B]PYRIDINE; 5 FLUORO 1 METHYL 3 [2 (1 METHYL 1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,4 B]PYRIDINE; 5 FLUORO 1 METHYL 3 [2 (1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 B]PYRIDINE; 5 FLUORO 3[2 (1H PYRROLO[2,3 B]PYRIDIN 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 B]PYRIDINE; 7 CHLORO 1 METHYL 3 [2 (1 METHYL 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 C]PYRIDINE; 7 CHLORO 3 [2 (1 METHYL 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 C]PYRIDINE; 7 CHLORO 3 [2 (5 FLUORO 1 METHYL 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 1 METHYL 1H PYRROLO[2,3 C]PYRIDINE; 7 CHLORO 3 [2 (5 FLUORO 1 METHYL 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 C]PYRIDINE; 7 CHLORO 3 [2 (5 FLUORO 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 1 METHYL 1H PYRROLO[2,3 C]PYRIDINE; 7 CHLORO 3 [2 (5 FLUORO 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 C]PYRIDINE; 7 CHLORO 3 [2 (5 METHOXY 1 METHYL 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 1 METHYL 1H PYRROLO[2,3 C]PYRIDINE; 7 CHLORO 3 [2 (5 METHOXY 1 METHYL 1H INDOL 3 YL) 1,3 THIAZOL 4 YL] 1H PYRROLO[2,3 C]PYRIDINE; ANTINEOPLASTIC AGENT; INDOLYL THIAZOLYL PYRROLO[2,3 C]PYRIDINE DERIVATIVE; NORTOPSENTIN DERIVATIVE; TERT BUTYL 3 [4 (7 CHLORO 1H PYRROLO[2,3 C]PYRIDIN 3 YL) 1,3 THIAZOL 2 YL] 1H INDOLE 1 CARBOXYLIC ACID; TERT BUTYL 3 [4 (7 CHLORO 1H PYRROLO[2,3 C]PYRIDIN 3 YL) 1,3 THIAZOL 2 YL] 5 METHOXY 1H INDOLE 1 CARBOXYLIC ACID; THIAZOLYL BIS PYRROLO[2,3 B]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; THIAZOLE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL VIABILITY; COLORECTAL CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LUNG CANCER CELL LINE; MELANOMA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; NON SMALL CELL LUNG CANCER; PROSTATE CANCER CELL LINE; RENAL CANCER CELL LINE; SUBSTITUTION REACTION; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG EFFECTS; HCT116 CELL LINE; SYNTHESIS;

APOPTOSIS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; G2 PHASE; HCT116 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR STRUCTURE; PYRIDINES; PYRROLES; THIAZOLES;

EID: 84921647811     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md13010460     Document Type: Article

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